KEAP1-Nrf2
The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.
Products for KEAP1-Nrf2
- Cat.No. 产品名称 Information
- GN10318 Danshensu A salvianolic acid with diverse biological activities
- GN10470 Eriodictyol 圣草酚是一种从中药中分离出来的黄酮类化合物,具有抗氧化和抗炎活性。
- GN10531 Dimethylfraxetin A coumarin with anti-inflammatory activity
- GN10654 (+)-Corynoline An isoquinoline alkaloid with diverse biological activities
- GN10415 Astilbin A flavonoid with diverse biological activities
- GN10038 Ginsenoside Rh3 Ginsenoside Rh3 是 Ginsenoside Rg5 的细菌代谢产物。
- GN10491 Mangiferin A xanthone glucoside with diverse biological activities