KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Cat.No. 产品名称 Information
GN10654 (+)-Corynoline An isoquinoline alkaloid with diverse biological activities
GC31691 (+)-DHMEQ
GC65610 (R)-5-Hydroxy-1,7-diphenyl-3-heptanone
GC15355 2-Trifluoromethyl-2'-methoxychalcone A potent activator of Nrf2
GC33815 4-Hydroxyphenylacetic acid A phenolic acid with anti-inflammatory and anti-steatotic activities
GC31648 4-Octyl Itaconate
4-Octyl Itaconate 是一种可渗透细胞的衣康酸酯衍生物。
GN10629 5,7-dihydroxychromone A flavone decomposition product with diverse biological activities
GC16120 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor
GN10415 Astilbin A flavonoid with diverse biological activities
GC15371 Bardoxolone An anti-inflammatory compound that activates Nrf2/ARE signaling
GC11572 Bardoxolone methyl A synthetic triterpenoid with potent anticancer and antidiabetic activity
GC34070 Brusatol (NSC 172924) A quassinoid with diverse biological activities
GC61636 CBR-470-2
GC35629 CDDO-dhTFEA
GC35630 CDDO-EA
GC32723 CDDO-Im (RTA-403) An activator of Nrf2 signaling
GC14787 Curcumin A yellow pigment with diverse biological activities
GC40226 Curcumin-d6 An internal standard for the quantification of curcumin
GN10318 Danshensu A salvianolic acid with diverse biological activities
GC34010 Danshensu (Dan shen suan A)
Danshensu是丹参的有效成分，能够激活Nrf2信号通路，保护心血管。
GC64971 DDO-7263
GC61419 Dibenzoylmethane
GC16590 Dimethyl Fumarate An antioxidant with immunological actions
GC62936 Dimethyl fumarate D6
GN10531 Dimethylfraxetin A coumarin with anti-inflammatory activity
GN10470 Eriodictyol 圣草酚是一种从中药中分离出来的黄酮类化合物，具有抗氧化和抗炎活性。
GC62957 Eriodictyol-7-O-glucoside A flavanone glucoside with diverse biological activities
GC15605 Ezetimibe A cholesterol transport inhibitor
GC60159 Ezetimibe ketone
GC66354 Ezetimibe-d4-1 An internal standard for the quantification of ezetimibe
GN10741 Garcinone D A xanthone with diverse biological activities
GN10038 Ginsenoside Rh3 Ginsenoside Rh3 是 Ginsenoside Rg5 的细菌代谢产物。
GC33092 Hesperin An isothiocyanate with diverse biological activities
GC11302 Hinokitiol A tropolone with diverse biological activities
GC66004 K67
GC36390 Keap1-Nrf2-IN-1
GC31321 KI696
GC34642 KI696 isomer
GC44006 Kinsenoside A glycoside with diverse biological activities
GN10491 Mangiferin A xanthone glucoside with diverse biological activities
GC31783 Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) Methyl protocatechuate (Methyl 3,4-dihydroxybenzoate, 3,4-Dihydroxybenzoic acid methyl ester, Protocatechuic Acid Methyl Ester) is also known as Protocatechuic Acid Methyl Ester. Protocatechuic Acid, a dihydroxybenzoic acid, is a major metabolite of antioxidant polyphenols found in green tea with antioxidant and anti-inflammatory effects.
GC38819 ML334 An inhibitor of the Nrf2-Keap1 protein-protein interaction
GC19254 ML385
An inhibitor of Nrf2
GC13058 NK 252 A Nrf2 activator
GC66054 Nrf2 activator-4
GC36773 Nrf2-IN-1
GC12821 Oltipraz A Nrf2 and CAR activator
GC13693 Omaveloxolone (RTA-408) A synthetic triterpenoid that blocks Keap1/Nrf2 signaling
GC15457 Pyridoxine A 4-methanol form of vitamin B₆
GC17393 Pyridoxine HCl A 4-methanol form of vitamin B₆