KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

Products for KEAP1-Nrf2

Cat.No. 产品名称 Information
GC17393 Pyridoxine HCl A 4-methanol form of vitamin B₆
GC50242 RA 839 RA 839 是 Keap1 的非共价小分子结合剂，Kd 约为 6 μM，是 Nrf2 信号传导的选择性激活剂。
GC63933 S-Allylmercaptocysteine S-allylmercaptocysteine 是一种从大蒜中提取的有机硫化合物，对各种肺部疾病具有抗炎和抗氧化作用。S-allylmercaptocysteine 通过多种途径发挥抗癌作用，如通过 TGF-β 信号通路诱导癌细胞凋亡 (apoptosis)，或通过降低 NF-κb 活性和上调 Nrf2 来达到抗炎和抗氧化的作用。
GC14352 TAT 14 TAT 14 是一种 14 聚体肽，可作为具有抗炎作用的 Nrf2 激活剂。
GC34057 TBHQ (tert-Butylhydroquinone) Tert-butylhydroquinone (TBHQ) is an antioxidant compound which is used to prevent lipid peroxidation and shows multiple cytoprotective actions. It is an activator of Nrf2.
GC61338 Toralactone Toralactone可从Cassiaobtusifolia中分离得到，通过Nrf2依赖的抗氧化机制介导肝保护。