Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC10408 2-D08 An inhibitor of sumoylation
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC12088 BAY-678 A selective, cell permeable inhibitor of human neutrophil elastase
GC11969 Adenosine-5'-diphosphate
二磷酸腺苷,Adenosine Pyrophosphate,ADP,5′-ADP

ATP precursor and purinergic receptor ligand
GC17245 MMP-13 Inhibitor
N4,N6-双(4-氟-3-甲基苄基)嘧啶-4,6-二甲酰胺,Collagenase-3 Inhibitor,Matrix Metalloproteinase-13 Inhibitor,4,6-Pyrimidinedicarboxamide
A selective MMP-13 inhibitor
GC11764 MMP Inhibitor II
Matrix Metalloproteinase Inhibitor II,NHDDPC,PG 117025,PGE 4410186
A broad-range inhibitor of MMPs
GC14433 7α,25-dihydroxy Cholesterol
7Α,25-二羟基胆固醇,7α,25-DHC
A potent and selective agonist of GPR183
GC16829 Arphamenine B (hemisulfate) An inhibitor of aminopeptidase B
GC13887 25(R)-27-hydroxy Cholesterol
27-羟基胆固醇
An endogenous agonist for LXR
GC14511 all-trans Retinal
视黄醛,Retinaldehyde,Vitamin A aldehyde
A natural retinoid
GC17423 TS 155-2
JBIR 100
An antihypertensive antibiotic
GC16438 L-Histidinol (hydrochloride)
L-组氨醇二盐酸盐,(S)-Histidinol
An intermediate in L-histidine biosynthesis
GC12829 5-hydroxy Tryptophol
5-羟基色醇
A metabolite of tryptophan
GC13454 L-Leucine 4-methoxy-β-naphthylamide (hydrochloride)
Leu-MNA
An aminopeptidase substrate
GC12235 Sitagliptin (phosphate)
磷酸西他列汀; MK-0431 phosphate
A DPP-4 inhibitor
GC14954 L-Canaline
6-硝基-2-氨苯酚-4-磺酸
A natural inhibitor of aminotransferases
GC11560 Resorcinolnaphthalein
NSC 354317
Activator of ACE2
GC10663 Dihydrodaidzein
二氢大豆苷元; (±)-Dihydrodaidzein
An active metabolite of daidzein
GC12732 TNP-470
O-(氯乙酰氨甲酰基)烟曲霉素醇,AGM-1470|O-(Chloroacetyl-carbamoyl) Fumagillol|NSC 642492
An inhibitor of angiogenesis
GC11847 (Z-Ala-Ala-Ala-Ala)2Rh110
(Z-Ala-Ala-Ala-Ala)2Rhodamine110|bis-(CBZ-L-alanyl-L-arginine amide) Rhodamine 110

A fluorogenic elastase substrate
GC10827 Oxipurinol
羟基嘌呤,Alloxanthine|NSC 76239
An inhibitor of xanthine oxidase and active metabolite of allopurinol
GC10694 Ramiprilat
雷米普利,Ramipril Diacid
An ACE inhibitor
GC15880 Penicillic Acid
青霉酸,NSC 402844
A mycotoxin that inhibits quorum sensing
GC11155 Omeprazole sulfone
奥美拉唑杂质A,Omeprazole sulfone; Omeprazole sulphone
The major metabolite of omeprazole
GC17711 PPACKII (trifluoroacetate salt)
H-D-Phe-Phe-Arg-Chloromethyl Ketone
An irreversible inhibitor of kallikreins
GC15815 Thymidine
胸苷; DThyd; NSC 21548

A pyrimidine nucleoside
GC10134 Ginkgolic Acid C15:1
银杏酸; Ginkgolic acid (15
An inhibitor of SUMOylation
GC10821 11-keto-β-Boswellic Acid
11-酮基-BETA-乳香酸,11-oxo-β-Boswellic acid,KBA
A 5-LO inhibitor
GC16350 Actinonin
放线酰胺素,(-)-Actinonin,Ro 06-1467
An aminopeptidase inhibitor
GC16823 Enniatin Complex
恩镰孢菌素复合物
A complex mixture of ionophores
GC11804 2-Guanidinoethylmercaptosuccinic Acid
GEMSA
A carboxypeptidase inhibitor
GC11981 Neutrophil Elastase Inhibitor A selective inhibitor of neutrophil elastase
GC12545 2-HBA
Bis(2-hydroxybenzylidene)acetone
An indirect inhibitor of Keap1-Nrf2 interactions
GC15726 NNGH
N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl Hydroxamic Acid,Matrix Metalloproteinase-3 Inhibitor II,MMP-3 Inhibitor II
A broad-spectrum MMP inhibitor
GC17693 Enniatin B
恩镰孢菌素 B
A natural inhibitor of Pdr5p in yeast
GC14786 P32/98 (hemifumarate)
异亮氨酸噻唑烷半富马酸盐
A DPP IV inhibitor
GC17287 Iberin
3-甲基亚磺酰丙基异硫氰酸酯,NSC 321801

A natural isothiocyanate
GC10533 7,8-dihydro-L-Biopterin
7,8-二氢生物蝶呤
A precursor in the synthesis of BH₄
GC15601 AG-120
艾伏尼布,AG-120
An IDH1 inhibitor
GC13147 AG-221 (Enasidenib)
恩西地平; AG-221
An inhibitor of mutant IDH2
GC16724 Sivelestat (ONO-5046)
西维来司他; EI546; LY544349; ONO5046
Sivelestat (ONO-5046) (EI546) 是人中性粒细胞弹性蛋白酶的竞争性抑制剂，IC50 为 44 nM，Ki 为 200 nM。 Sivelestat (ONO-5046) (EI546) 具有研究 COVID-19 中急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的潜力。
GC15993 Lauric Acid
月桂酸
A medium-chain fatty acid
GC10042 Vitamin E
天然维生素E
脂溶性维生素
GC13621 Hexylresorcinol
4-己基间苯二酚; 4-Hexylresorcinol
An alkylresorcinol
GC10396 S-Adenosylhomocysteine
S-(5'-腺苷)-L-高半胱氨酸,SAH (S-Adenosylhomocysteine); AdoHcy

S-腺苷同型半胱氨酸 (SAH) （S-Adenosylhomocysteine）是一种氨基酸衍生物，是蛋氨酸代谢中的关键中间代谢产物。
GC12713 5-Aminovaleric acid hydrochloride
5-氨基戊酸
5-氨基戊酸盐酸盐被认为是 γ-氨基丁酸 (GABA) 的亚甲基同系物，并作为弱 GABA 激动剂发挥作用。
GC12431 RSL3
(1S,3R)-RSL3
RSL3被认为是一种强效的诱导铁死亡剂，其作用依赖于GPX4的活性。
GC18136 BH3I-1
BHI1; BH 3I1
An inhibitor of anti-apoptotic Bcl-2 proteins
GC11222 Methylthioadenosine
5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-S-Methyl-5'-thioadenosine
Methylthioadenosine是多胺生物合成过程中由 S-腺苷甲硫氨酸(SAMe)产生的含硫腺嘌呤核苷。Methylthioadenosine常用于结肠炎、肝病和各种癌症疾病的研究。
GC15059 Sulindac sulfide
cis-Sulindac sulfide
An active metabolite of sulindac