Penicillic Acid
(Synonyms: 青霉酸,NSC 402844) 目录号 : GC15880A mycotoxin that inhibits quorum sensing
Cas No.:90-65-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1].
In vitro: The compound was active primarily against gram-negative bacteria, and it was also active against some gram-positive species. It showed limited antihelminthic properties but did affect the growth of oat seed coleoptiles by interference with the respiratory process. Penicillic acid has proven to be too toxic for use in therapy [1]. Penicillic acid (80 μM) inhibited bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes [2]. In Burkitt’s lymphoma Raji cells, penicillic acid exihibited an inhibitory effect on Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity [3].
In vivo: The LDso (subcutaneous injection) for mice is 100 mg/kg. Subcutaneous injection of 1.0 mg/dose twice weekly produced transplantable tumors after 64 weeks in all rats surviving treatment. In addition, a dose at 0.1 mg initiated tumor development [1].
References:
[1] Ciegler A, Detroy R W, Lillehoj E B. Patulin, penicillic acid, and other carcinogenic lactones[J]. Microbial toxins, 1971, 6: 409-434.
[2] Rasmussen T B, Skindersoe M E, Bjarnsholt T, et al. Identity and effects of quorum-sensing inhibitors produced by Penicillium species[J]. Microbiology, 2005, 151(5): 1325-1340.
[3] Bando M, Hasegawa M, Tsuboi Y, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex[J]. Journal of Biological Chemistry, 2003, 278(8): 5786-5793.
| Cas No. | 90-65-3 | SDF | |
| 别名 | 青霉酸,NSC 402844 | ||
| 化学名 | 3-methoxy-5-methyl-4-oxo-2,5-hexadienoic acid | ||
| Canonical SMILES | C=C(C)C(/C(OC)=C\C(O)=O)=O | ||
| 分子式 | C8H10O4 | 分子量 | 170.2 |
| 溶解度 | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.8754 mL | 29.3772 mL | 58.7544 mL |
| 5 mM | 1.1751 mL | 5.8754 mL | 11.7509 mL |
| 10 mM | 0.5875 mL | 2.9377 mL | 5.8754 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。