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Hexadecyl Methyl Glycerol Sale

(Synonyms: 1-O-hexadecyl-2-O-methyl-sn-Glycerol) 目录号 : GC10299

A synthetic DAG

Hexadecyl Methyl Glycerol Chemical Structure

Cas No.:96960-92-8

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10mg
¥444.00
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50mg
¥872.00
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100mg
¥1,522.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Hexadecyl Methyl Glycerol, also known as AMG-C16 with a hexadecyl chain at the sn-1 position, is a novel inhibitor of protein kinase C with IC50 value of about 80 μM [1].

Protein kinase C is a phospholipid-dependent kinase and the intracellular receptor for phorbol 12-myristate-13-acetate (PMA), a substance that activates both the respiratory burst and protein kinase C. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+) [1].

Hexadecyl Methyl Glycerol is a structural analog of diacylglycerol with a hexadecyl chain at the sn-1 position and a methyl group at the sn-2 position. Hexadecyl Methyl Glycerol inhibited the activation of purified protein kinase C by diacylglycerol in the presence of phosphatidylserine. In neutrophilic granulocytes, Hexadecyl Methyl Glycerol inhibited the respiratory burst induced by PDBu in a dose-dependent way. In neutrophils, Hexadecyl Methyl Glycerol inhibited the phosphorylation of purified 47-kDa protein, an important substrate of protein kinase C [1].

Reference:
[1].  Kramer IM1, van der Bend RL, Tool AT, et al. 1-O-hexadecyl-2-Q-methylglycerol, a novel inhibitor of protein kinase C, inhibits the respiratory burst in human neutrophils. J Biol Chem. 1989 Apr 5;264(10):5876-84.

Chemical Properties

Cas No. 96960-92-8 SDF
别名 1-O-hexadecyl-2-O-methyl-sn-Glycerol
化学名 1-O-hexadecyl-2-O-methyl-sn-glycerol
Canonical SMILES CCCCCCCCCCCCCCCCOCC(CO)OC
分子式 C20H42O3 分子量 330.6
溶解度 ≤8.3mg/ml in DMSO;8.3mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 3.0248 mL 15.124 mL 30.248 mL
5 mM 0.605 mL 3.0248 mL 6.0496 mL
10 mM 0.3025 mL 1.5124 mL 3.0248 mL
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