Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC45144 Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)
维达列汀羧基酸代谢物三氟醋酸盐
A major metabolite of vildagliptin
GC45137 Valproic Acid Acyl-D-Glucuronide
Valproic Acid Gluclonide
A metabolite of valproic acid
GC45135 Validamycin A
井冈霉素
An inhibitor of trehalase
GC45134 Valeryl-L-carnitine (chloride)
L-戊酰基肉碱,L-Valerylcarnitine
A short-chain acylcarnitine
GC45111 UDP-α-D-Glucose (sodium salt)
二磷酸尿苷葡萄糖二钠盐,UDP-D-Glucose disodium salt; Uridine 5′-diphosphoglucose disodium salt
A stereoisomer of UDP-α-D-glucose
GC45109 Ubiquinol
水溶型辅酶Q10
A reduced form of coenzyme Q₁₀
GC45090 Triparanol
曲帕拉醇,MER-29
An inhibitor of DHCR24
GC45086 Trigalacturonic Acid
半乳糖醛酸
三半乳糖醛酸是一种低聚糖，可抑制番茄植物中的蛋白酶活性（ED50 \u003d 2.6 μg/植物）。
GC45084 Tridecanoic Acid
十三酸; N-Tridecanoic acid
A 13-carbon saturated fatty acid
GC45066 Tosyl Phenylalanyl Chloromethyl Ketone
L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
An inhibitor of chymotrypsin-like serine proteases
GC45031 Thiamine (hydrochloride)
Aneurine, Vitamin B1
Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties.
GC45024 tetranor-12(S)-HETE
tetranor-12(S)-Hydroxyeicosatetraenoic Acid
A peroxisome metabolite of 12(S)-HETE
GC45020 Tetrachlorohydroquinone
四氯氰醌
A metabolite of pentachlorophenol
GC45012 Tenofovir diphosphate (sodium salt)
PMPApp, TFV-DP
An HIV reverse transcriptase and HBV polymerase inhibitor
GC45007 Telmisartan Acyl-β-D-Glucuronide
(替米沙坦酰基)-Β-D-葡糖苷酸
A major metabolite of telmisartan
GC45001 Tazarotenic Acid
他扎罗汀酸,AGN 190299
An active metabolite of tazarotene
GC44995 Taurodeoxycholic Acid (sodium salt)
牛磺脱氧胆酸钠
牛磺脱氧胆酸 (TDCA) 是一种胆汁盐，通常存在于肠腔内。
GC44992 Taurochenodeoxycholic Acid (sodium salt)
牛磺鹅去氧胆酸钠盐; 12-Deoxycholyltaurine sodium
A taurine-conjugated form of chenodeoxycholic acid
GC44990 Tanomastat
(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸,BAY 12-9566
An inhibitor of MMP-2, -3, and -9
GC44982 T-2 Triol
T-2三醇
An active metabolite of T-2 toxin
GC44951 Stearoyl-L-carnitine (chloride)
C18 Carnitine
A long-chain acylcarnitine
GC44928 Sphingomyelins (from bovine spinal cord)
鞘磷脂
A sphingolipid
GC44917 Sorafenib N-oxide
索拉非尼N氧化物
An active metabolite of sorafenib
GC44913 Solifenacin N-oxide
索利那新N-氧化物
An inactive metabolite of solifenacin
GC44912 Solifenacin N-Glucuronide A metabolite of solifenacin
GC44908 sn-Glycerol-3-phosphate (cyclohexyl ammonium salt)
G3P
A lipid biosynthesis intermediate
GC44895 Sitagliptin N-Sulfate (sodium salt) A metabolite of (–)-sitagliptin
GC44891 Simeprevir (sodium salt)
西咪匹韦钠; TMC435 sodium; TMC435350 sodium
A potent NS3/4A protease inhibitor
GC44890 Silodosin Glucuronide (sodium salt)
赛洛多辛β-D-葡萄糖苷酸钠盐
An active metabolite of silodosin
GC44879 Sclerotiorin
核丛青霉素
A natural compound with LOX and CETP inhibitory activity
GC44874 Saxagliptin (hydrochloride)
沙克列汀中间体,BMS-477118 hydrochloride
A potent DPP-4 inhibitor
GC44867 SAICAR
Succino-AICAR
An intermediate for purine synthesis
GC44862 S3QEL-2 A suppressor of mitochondrial electron leak
GC44860 S1QEL1.1
S1QEL
A suppressor of I_Q electron leak
GC44820 Resveratrol-3-O-Sulfate (sodium salt) An active metabolite of resveratrol
GC44818 Resolvin D4
RvD4
A pro-resolving mediator
GC44815 Resolvin D1
17(S)-Resolvin D1, RvD1
A product of the action of 15- and 5-LO on DHA
GC44810 Reduced Haloperidol
还原氟哌啶醇
An active metobolite of haloperidol
GC44803 rac-7-hydroxy Propranolol (hydrochloride)
7-羟基普萘洛尔盐酸盐
An isomer and metabolite of propranolol
GC44799 Quinidine N-oxide A quinidine metabolite
GC44795 Quercetin 3-O-glucuronide
槲皮素3-O-葡萄糖酸苷,Quercetin 3-O-glucuronide; Quercetin 3-glucuronide
A flavonol glucuronide inhibitor of the α_2c adrenergic receptor
GC44793 Pyrroloquinoline quinone
吡咯喹啉醌; PQQ; Methoxatin
据报道，吡咯并喹啉醌是一种新的哺乳动物乳酸脱氢酶 (LDH) 辅酶。
GC44785 Pyridoxal 5'-phosphate (hydrate)
3-羟基-2-甲基-5-磷酰氧甲基-4-吡啶甲醛,Pyridoxal phosphate hydrate
An enzyme cofactor
GC44699 Propranolol β-D-Glucuronide (sodium salt) A major metabolite of propranolol
GC44680 Pregnenolone sulfate (sodium salt)
3β-Hydroxy-5-pregnen-20-one monosulfate sodium
A metabolite of pregnenolone
GC44676 Pravastatin lactone
普伐他汀类酯
A metabolite of pravastatin
GC44668 Posaconazole D-Glucuronide
Posaconazole N-β-D-Glucuronide
A metabolite of posaconazole
GC44665 PNU 142300
利奈唑胺杂质8
An inactive metabolite of linezolid
GC44659 PKSI-527 An inhibitor of plasma kallikrein
GC44650 Pitavastatin lactone
匹伐他汀内酯
A major phase 2 metabolite of pitavastatin