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Home >> Signaling Pathways >> Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. 产品名称 Information
  2. GC12339 Ivermectin

    伊维菌素; MK-933

     A mixture of ivermectin B1a and ivermectin B1b
  3. GC15618 Melatonin

    褪黑素; N-Acetyl-5-methoxytryptamine

    An indoleamine neurohormone that entrains circadian rhythms
  4. GC12838 Edaravone

    依达拉奉; MCI-186

     A free radical scavenger
  5. GC15917 CA-074 Me

    L-TRANS-环氧琥珀酸-ILE-PRO-OME丙醛,CA-074Me

     CA-074 Me（CA-074甲酯）是组织蛋白酶B（CB）的特异性抑制剂。
  6. GC12725 VX-765

    Belnacasan; N-(4-氨基-3-氯苯甲酰基)-3-甲基-L-缬氨酰-N-[(2R,3S)-2-乙氧基四氢-5-氧代-3-呋喃基]-L-脯氨酰胺; VX-765

    VX-765 是一种新开发的选择性小分子 caspase-1 抑制剂，可通过血脑屏障并在体外和体内减少炎症。
  7. GC11065 Pifithrin-μ

    NSC 303580

     Inhibitor of p53-mediated apoptosis
  8. GC12604 Fumonisin B1

    伏马菌素B1

    A mycotoxin
  9. GC13590 SJ 172550

    MDMX Inhibitor II

     A small molecule inhibitor of MDMX
  10. GC16844 BC 11 hydrobromide Selective urokinase inhibitor
  11. GC13337 4-Chlorophenylguanidine hydrochloride

    洗必泰二乙酸杂质

     Urokinase inhibitor, potent and specific
  12. GC15954 UK 356618 An inhibitor of MMP-3
  13. GC14578 GI 254023X

    (ALPHAR)-N-[(1S)-2,2-二甲基-1-[(甲基氨基)羰基]丙基]-ALPHA-[(1S)-1-(甲酰基羟基氨基)乙基]苯戊酰胺,GI4023; SRI028594

     GI 254023X是一种选择性抑制剂，针对MMP9（Matrix Metalloproteinase 9）的IC50 值为5.3nM，GI 254023X对ADAM10（A Disintegrin and Metalloproteinase 10）的选择性是ADAM17的100倍，IC50 值为2.5nM。GI 254023X主要用于免疫学、炎症和神经退行性疾病的研究。
  14. GC14126 NVP DPP 728 dihydrochloride NVP DPP 728 dihydrochloride 是一种有效的、可逆的和腈依赖性二肽基肽酶 IV (DPP-IV) 抑制剂。
  15. GC10258 Ac-IEPD-AFC Ac-IEPD-AFC 是颗粒酶 B 的底物。
  16. GC12659 Begacestat

    GSI-953

     An inhibitor of γ-secretase
  17. GC10064 Flurizan

    R-氟比洛芬; (R)-Flurbiprofen; MPC7869

     A COX-inactive enantiomer of flurbiprofen
  18. GC18065 ZJ 43 ZJ 43 是一种有效的 NAAG 肽酶抑制剂，IC50 为 2.4 nM，Ki 为 0.8 nM。
  19. GC13707 WAY 170523 WAY 170523 是一种有效的选择性 MMP-13（基质金属蛋白酶 13）抑制剂，IC50 为 17 nM。 WAY 170523 可以直接减弱 ERK1/2 磷酸化。 WAY 170523抑制PC-3细胞的侵袭，可用于前列腺癌研究。
  20. GC16579 UK 370106 UK 370106 是一种有效且高度选择性的 MMP-3（IC50 为 23 nM）和 MMP-12（IC50 为 42 nM）抑制剂，其效力比 MMP-1、MMP-2、MMP-9 和 MMP 高 1200 倍以上-14，大约是 MMP-13 和 MMP-8 的 100 倍。
  21. GC10672 SSR 69071 A potent inhibitor of neutrophil elastase
  22. GC16894 Spinorphin

    LVV-hemorphin-4

     A peptide inhibitor of enkephalin-degrading enzymes
  23. GC17247 Sivelestat sodium salt

    西维来司钠; ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium

     An inhibitor of neutrophil elastase
  24. GC10377 SID 26681509 SID 26681509 是一种有效的、可逆的、竞争性的、选择性的人组织蛋白酶 L 抑制剂，IC50 为 56 nM。
  25. GC18011 SC 57461A

    N-甲基-N-[3-[4-(苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐

     A potent, orally active inhibitor of LTA4 hydrolase
  26. GC10805 Ro 32-3555

    Ro 32-3555

     Ro 32-3555 是一种有效的、竞争性的人类胶原酶 1、2 和 3 抑制剂，Kis 分别为 3.0、4.4 和 3.4 nM。
  27. GC13467 PMPA (NAALADase inhibitor)

    2-(Phosphonomethyl)pentanedioic acid

     A potent inhibitor of GCP II/NAALADase
  28. GC14201 PK 44 phosphate

    DPP-IV inhibitor
  29. GC14886 PETCM

    Α-(三氯甲基)-4-吡啶乙醇

     PETCM 是 caspase-3 的激活剂，并以细胞色素 c (细胞 c) 依赖性方式发挥作用。 PETCM 促进 Apaf-1 寡聚化并诱导 HeLa 细胞中的细胞凋亡。
  30. GC12111 PD 166793

    N-[(4'-溴[1,1'-联苯]-4-基)磺酰基]-L-缬氨酸

     An broad-spectrum MMP inhibitor
  31. GC16912 PD 150606 An inhibitor of calpains
  32. GC15005 ONO 4817

    MMP Inhibitor V

     An inhibitor of MMP-2 and MMP-9
  33. GC16431 MRK 560 A potent inhibitor of γ-secretase
  34. GC11640 MDL 28170

    Calpain Inhibitor III

     A cell permeable, selective calpain inhibitor
  35. GC15364 L-685,458

    L-685,458

     A γ-secretase inhibitor
  36. GC17989 L 006235

    L-235

     An inibitor of cathepsin K
  37. GC10802 K 579 K 579 是一种有效且具有口服活性的二肽基肽酶 IV 抑制剂。
  38. GC13619 JLK 6

    7-Amino-4-chloro-3-methoxy-1H-2-benzopyran

     A protease inhibitor
  39. GC18137 Ivachtin

    Caspase-3 Inhibitor VII

     A reversible caspase-3 inhibitor
  40. GC12358 Fumagillin

    烟曲霉素; Amebacilin; NSC9168

     A fungal metabolite with diverse biological activities
  41. GC12603 DPPI 1c hydrochloride A DPP-4 inhibitor
  42. GC12157 CP 471474

    2-[[[4-(4-氟苯氧基)苯基]磺酰基]氨基]-N-羟基-2-甲基丙酰胺

     A broad-spectrum MMP inhibitor
  43. GC15645 Compound W

    3,5-二(4-硝基苯氧基)苯甲酸,CW3,5-Bis(4-nitrophenoxy)benzoic acid

     A Notch1 signaling modulator
  44. GC15952 CL 82198 hydrochloride An inhibitor of MMP-13
  45. GC10342 Calpeptin

    A calpain inhibitor
  46. GC13099 BMS 299897

    2-[(1R)-1-[[(4-氯苯基)磺酰基](2,5-二氟苯基)氨基]乙基]-5-氟苯丁酸

     A γ-secretase inhibitor
  47. GC13171 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  48. GC12465 ARP 101 ARP 101 是一种有效的选择性抑制剂基质金属蛋白酶 2 (MMP-2)。 ARP 101 在癌细胞中诱导自噬相关的细胞死亡。 ARP 101 可有效诱导自噬体的形成和 LC3I 转化为 LC3II。
  49. GC13487 ARP 100

    CAY10609

     A selective inhibitor of MMP-2
  50. GC10968 Ac-LEHD-AFC A caspase-4, -5, and -9 fluorogenic substrate
  51. GC12152 Acetyl-Calpastatin (184-210) (human)

    乙酰钙蛋白酶抑制蛋白(184-210)(人)

     Acetyl-Calpastatin (184-210) (human) 是一种有效、选择性和可逆的钙蛋白酶抑制剂，对 µ-calpain 和组织蛋白酶 L 的 Ki 值分别为 0.2 nM 和 6 μM。

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