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Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. Product Name Information
  2. GC38287 α-Pyridone

    α-Pyridone 是一种内源性代谢产物。

  3. GC38000 β-Boswellic acid β-Boswellic acid 是从乳香 Boswellia serrate 的树胶脂中分离出来的。β-Boswellic acid 是 5-脂氧合酶 (5-LO) 产物形成的非还原型抑制剂,其直接与 5-LO 相互作用或阻断其易位。β-Boswellic acid 抑制人白血病 HL-60 细胞中 DNA,RNA和蛋白质的合成。
  4. GC38010 γ-Aminobutyric acid

    γ-Aminobutyric acid (4-Aminobutyric acid) 是成年哺乳动物大脑中主要的抑制性神经递质,能够与离子移变 GABA 受体 (GABAA) 受体和促代谢受体 (GABAB) 受体结合发挥作用。

  5. GC38011 γ-Secretase modulator 4 γ-Secretase modulator 4 是一种有效的 γ- 分泌酶调节剂 (γ-secretase),在人类和小鼠中降低 Aβ42 产生的 IC50 值分别为 0.014 μM 和 0.017 μM。
  6. GC15975 α-Estradiol Endogenous estrogen receptor ligand
  7. GC34961 (±)-BI-D (_plusmn_)-BI-D是HIV整合酶(integrase)变构抑制剂,作用于整合酶与LEDGF/p75结合部位。
  8. GC41670 (±)-Epinephrine (hydrochloride) (±)-Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors (Kis = 15, 735, and 3,970 nM for α1A-, β2-, and β1-adrenergic receptors, respectively).
  9. GC38369 (±)-Leucine (±)-Leucine 是一种内源性代谢产物。
  10. GC13890 (±)-Palmitoylcarnitine chloride intermediate in mitochondrial fatty acid oxidation
  11. GC30586 (±) Anabasine (±)Anabasine是一种肌肉松弛剂,可用于外科手术时肌肉松驰。
  12. GC10675 (+,-)-Octopamine HCl adrenoceptor agonist
  13. GC17470 (-)-Cotinine α3/α6β2 nAChR activator
  14. GC17242 (-)-epigallocatechin green tea epicatechin
  15. GC14049 (-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent
  16. GC31620 (-)-Fucose (6-Desoxygalactose) (-)-Fucose是己糖中的一种,在AB血型抗原亚型结构的决定、选择素-介导的白细胞内皮粘附以及宿主-微生物相互作用中发挥作用。
  17. GC38299 (2-Aminoethyl)phosphonic acid (2-Aminoethyl)phosphonic acid 是一种内源性代谢产物。
  18. GC38265 (2R,3R)-2,3-Dihydroxysuccinic acid (2R,3R)-2,3-Dihydroxysuccinic acid 是一种内源性代谢产物。
  19. GC38296 (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride 是一种内源性代谢产物。
  20. GC33797 (3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine hydrochloride) (3-Carboxypropyl)trimethylammoniumchloride是肠道微生物代谢产生的一种血管病变性中间代谢物,这些微生物以红肉中的肉碱为食。
  21. GC38283 (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one 是一种内源性代谢产物。

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