Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GN10549 Ginsenoside Rd
人参皂苷 Rd; Gypenoside VIII
A natural steroid glycoside with diverse effects
GN10307 Ginsenoside Re
人参皂苷 Re; Ginsenoside B2; Panaxoside Re; Sanchinoside Re
A natural steroid glycoside with diverse effects
GN10544 Ginsenoside Rg1
人参皂苷 Rg1; Panaxoside A; Panaxoside Rg1
人参皂苷Rg1是人参的主要活性成分之一，是一种具有多种生物活性的甾体糖苷。人参皂苷Rg1可降低大脑Aβ 水平并减少 NF-κB 核转移。
GN10614 Ginsenoside Rg2
人参皂苷 Rg2; Chikusetsusaponin I; Panaxoside Rg2; Prosapogenin C2
A natural steroid glycoside with diverse effects
GN10799 20(S)-Ginsenoside Rg3
20(S)-人参皂苷 Rg3; 20(S)-Propanaxadiol; S-ginsenoside Rg3
20(S)-Ginsenoside Rg3是从人参中提取的稀有人参皂苷（Na⁺：IC₅₀ = 32.2±4.5μM；hKv1.4：IC₅₀ = 32.6±2.2μM）。
GN10695 Notoginsenoside R1
三七皂甙R1,Sanchinoside R1; Sanqi glucoside R1
A saponin
GN10395 Prim-O-glucosylcimifugin
升麻素苷；升麻苷
A chromone with diverse biological activities
GN10086 Jujuboside A
酸枣仁皂苷 A
Jujuboside A 是一种从刺子中提取的糖苷，刺子是一种用于治疗失眠和焦虑的中草药。
GN10745 (+)-Bicuculline
(+)-荷包牡丹碱,Bucuculline
(+)-荷包牡丹碱((+)-Bicuculline ))是一种竞争性GABA_A受体拮抗剂，IC₅₀为2μM。
GN10607 Nuciferine
荷叶碱
An alkaloid with diverse biological activities
GN10428 Geniposide
栀子苷

An iridoid glycoside with diverse biological activities
GN10039 Rutaecarpine
吴茱萸次碱; Rutecarpine
Rutaecarpine是一种从吴茱萸中分离出的吲哚并吡啶喹唑啉生物碱，已知在细胞水平上以0.28μM的IC₅₀抑制COX-2。
GN10740 Tetrahydropalmatine
延胡索乙素; DL-Tetrahydropalmatine
四氢巴马汀具有镇痛作用。
GN10680 Puerarin
葛根素
A natural isoflavonoid
GA11306 H-D-Ser-OH
D-丝氨酸; (R)-Serine
An NMDA co-agonist
GC14202 KN-62
1-[N,O-二(5-异喹啉磺酰基)-N-甲基-L-型酪氨酸]-4-苯基哌嗪
Inhibitor of Ca²⁺/calmodulin-dependent kinase type II
GA10664 H-Dab•HBr
L-2,4-二氨基丁酸氢溴酸盐,L-2,4-Diaminobutyric acid
H-Dab•HBr (L-2,4-Diaminobutyric acid) 是一周 GABA 转氨酶抑制剂，IC50 大于 500 μM;在体内和体外均表现出抗肿瘤活性。
GA10004 H-D-Met-OH
D-蛋氨酸,MRX-1024; D-Methionine
H-D-Met-OH (MRX-1024; D-H-D-Met-OH) 是一种有效的化学保护剂，还可以通过 GABAA 受体激活抑制神经元活性。
GA10922 H-Gly-OH
甘氨酸
H-Gly-OH 是 CNS 中的一种抑制性神经递质，还与谷氨酸一起作为共激动剂，促进谷氨酰胺能 N-甲基-D-天冬氨酸 (NMDA) 受体的兴奋电位。
GA10750 H-Glu-OH
L-谷氨酸
H-Glu-OH 在谷氨酸受体的所有亚型（代谢型、红藻氨酸、NMDA 和 AMPA）中充当兴奋性递质和激动剂。
GA11338 H-D-Asp-OH
D-天门冬氨酸,(R)-Aspartic acid; D-(-)-Aspartic acid
An amino acid and a precursor in NMDA biosynthesis
GC11058 Scrambled 10Panx
Scrambled 10Panx Phe-Ser-Val-Tyr-Trp-Ala-Gln-Ala-Asp-Arg

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions
GC13863 10Panx
10Panx
A peptide inhibitor of PANX1
GC11965 (±)-Huperzine A
(±)-石杉碱甲
A neuroprotective AChE inhibitor
GP10076 Agouti-related Protein (AGRP) (25-82), human
H2N-Leu-Ala-Pro-Met-Glu-Gly-Ile-Arg-Arg-Pro-Asp-Gln-Ala-Leu-Leu-Pro-Glu-Leu-Pro-Gly-Leu-Gly-Leu-Arg-Ala-Pro-Leu-Lys-Lys-Thr-Thr-Ala-Glu-Gln-Ala-Glu-Glu-Asp-Leu-Leu-Gln-Glu-Ala-Gln-Ala-Leu-Ala-Glu-Val-Leu-Asp-Leu-Gln-Asp-Arg-Glu-Pro-Arg-OH

Agouti-related peptide(25-82)
GP10106 Parathyroid Hormone (1-34), bovine
牛甲状旁腺激活素-(1-34),H2N-Ala-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
甲状旁腺激素 (1-34), bovine 是一种有效的甲状旁腺激素 (PTH) 受体激动剂。
GP10011 Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell
Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys-OH
一氧化氮生产阻滞剂
GP10094 Amyloid β-peptide (10-35), amide
H2N-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2
Truncated peptide model
GP10084 type II collagen fragment
H2N-Gly-Glu-Pro-Gly-Ile-Ala-Gly-Phe-Lys-Gly-Glu-Gln-Gly-Pro-Lys-OH

Specific for cartilaginous tissues
GP10042 Rhodopsin peptide
H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH
视网膜感光细胞色素;GPCR
GP10032 Rac GTPase fragment
H2N-Val-Phe-Asp-Glu-Ala-Ile-Arg-Ala-Val-OH

Fragment of small signaling G proteins
GP10014 parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]
H2N-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH

Enhancer of blood calcium level
GP10146 ferritin heavy chain fragment [Multiple species]
H2N-Tyr-Leu-Asn-Glu-Gln-Val-Lys-Ala-Ile-OH

Ferritin heavy chain fragment
GP10099 amyloid A protein fragment [Homo sapiens]
H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH
Apolipoproteins related to HDL in plasma
GP10017 [Ser25] Protein Kinase C (19-31)
H2N-Arg-Phe-Ala-Arg-Lys-Gly-Ser-Leu-Arg-Gln-Lys-Asn-Val-OH

PKC substrate
GP10109 Adrenorphin
H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-amide

Adrenorphin 是一种阿片样物质八肽，作为 μ-阿片样物质受体的有效激动剂，Ki 为 12 nM。
GP10006 Myelin Basic Protein (68-82), guinea pig
豚鼠髓磷脂碱性蛋白片段68-82,H2N-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH
髓鞘碱性蛋白 (68-82)，豚鼠是髓鞘碱性蛋白 (MBP) 的片段。
GP10127 Cadherin Peptide, avian
H2N-Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-amide

Role in cell adhesion
GP10103 Laminin (925-933)
H2N-Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg-OH
层粘连蛋白（925-933）（CDPGYIGSR）是层粘连蛋白 B1 链上的序列。
GP10115 GTP-Binding Protein Fragment, G alpha
H2N-Cys-Gly-Ala-Gly-Glu-Ser-Gly-Lys-Ser-Thr-Ile-Val-Lys-Gln-Met-Lys-OH

Hydrolyzes GTP to GDP
GP10102 Adrenorphin, Free Acid
Adrenorphin, Free Acid,H2N-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-OH

μ/κ opioid receptor agonist
GP10121 Ac-Endothelin-1 (16-21), human
Ac-His-Leu-Asp-Ile-Ile-Trp-OH

ETA/ETB agonist,vasoconstrictor
GP10081 α-Endorphin
α-内啡肽,H2N-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH
An endogenous opioid peptide
GP10051 Beta-Lipotropin (1-10), porcine
H2N-Glu-Leu-Ala-Gly-Ala-Pro-Pro-Glu-Pro-Ala-OH

Morphine-like substance
GP10070 Dynorphin (2-17), amide, porcine
H2N-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-amide

A modulator of pain response
GP10101 Beta-Sheet Breaker Peptide iAβ5
H2N-Leu-Pro-Phe-Phe-Asp-OH

Peptide which can inhibit amyloidogenesis
GP10046 Amyloid Precursor C-Terminal Peptide
H2N-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH

For beta amyloid generation
GP10097 Amyloid β-Protein (1-15)
H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH

淀粉样蛋白 β-蛋白 (1-15) 是 β-淀粉样蛋白肽的片段。
GP10083 Beta-Amyloid (1-11)
H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH

Beta-Amyloid (1-11) 是 Amyloid-&#946 的片段；肽，可用于神经系统疾病的研究。
GP10111 β-Pompilidotoxin
Arg-Ile-Lys-Ile-Gly-Leu-Phe-Asp-Gln-Leu-Ser-Arg-Leu

β-Pompilidotoxin (β-PMTX)，一种黄蜂毒液，可以减缓钠通道失活并增加细胞中的稳态钠电流。