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amyloid A protein fragment [Homo sapiens]

目录号 GP10099

Apolipoproteins related to HDL in plasma

规格 价格 库存 购买数量
1mg
¥357.00
现货
5mg
¥1,050.00
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10mg
¥1,733.00
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25mg
¥2,394.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH), also called Serum amyloid A (SSA) proteins, are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma. Different isoforms of SAA are expressed constitutively (constitutive SAAs) at different levels or in response to inflammatory stimuli (acute phase SAAs).

These proteins are produced predominantly by the liver. [1] The conservation of these proteins throughout invertebrates and vertebrates suggests that SAAs play a highly essential role in all animals. [2]

Serum amyloid A (SAA) is also an acute phase marker that responds rapidly. Like CRP, levels of acute-phase SAA increase within hours after an inflammatory stimulus, but the magnitude of increase may be greater than that of CRP. Relatively trivial inflammatory stimuli can lead to SAA responses. It has been suggested that SAA levels correlate better with disease activity in early inflammatory joint disease than do ESR and CRP levels. Although SAA is largely produced by hepatocytes, more recent studies show that SAA is also produced by adipocytes and that its serum concentration is associated with body mass index. [3]

Ref:

1. Uhlar CM, Whitehead AS (1999). "Serum amyloid A, the major vertebrate acute-phase reactant". Eur. J. Biochem. 265 (2): 501–23. Fei, DTW. et al. (1980) Life Sci. 27, 1495.

2. Manley PN, Ancsin JB, Kisilevsky R (2006). "Rapid recycling of cholesterol: the joint biologic role of C-reactive protein and serum amyloid A". Med. Hypotheses 66 (4): 784–92.

3. Zhang N, Ahsan MH, Purchio AF, West DB (2005). "Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition". J. Immunol. 174 (12): 8125–34.

Chemical Properties

Cas No. SDF
别名 H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH
Canonical SMILES CC(N)C(NCC(NC(C(N1CCC[C@@H]1C(NC(C(NC(CCCCN)C(N[C@@H](CC2=CC=C(O)C=C2)C(O)=O)=O)=O)CCC(O)=O)=O)=O)CC(C)C)=O)=O
分子式 C36H56N8O11 分子量 776.88
溶解度 ≥ 77.7mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
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