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α-Endorphin

目录号 GP10081

Neurotransmitters

规格 价格 库存 购买数量
1mg
¥252.00
现货
5mg
¥735.00
现货
10mg
¥1,302.00
现货
25mg
¥1,817.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

α-Endorphin is an endogenous opioid peptide with a length of 16 amino acids, and the amino acid sequence: Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr.[1]
α-endorphin is the strongest peptide in delaying avoidance behaviors. Alpha Endorphin has C-terminal sequence of β-LPH, allowing these peptides to have a high affinity for opiate binding sites. Even a slight difference in C-terminal amino acid can have drastic effects on avoidance behavior. The importance in sequencing determines the function of the endorphin.[7] When an N-terminal amino acid such as tyrosine is removed, there seems to be no significant impacts on avoidance behavior. However, when there are adjustments to the C-terminal sequence, like removing β-LPH 61-65; activity of the endorphin decreases.[2]

References:
[1].Hazum E, Chang KJ, Cuatrecasas P (September 1979). "Specific nonopiate receptors for beta-endorphin". Science. 205 (4410): 1033–1035.
[2].de Wied D (1981-01-01). "Neuropeptides in Normal and Abnormal Behavior". In Stark E, Makara GB, Ács Z, Endrőczi E (eds.). Endocrinology, Neuroendocrinology, Neuropeptides. Pergamon. pp. 23–38.

Chemical Properties

Cas No. 59004-96-5 SDF
别名 H2N-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-OH
化学名 N/A
Canonical SMILES CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(C(C)O)C(=O)O)NC(=O)C1CCCN1C(=O)C(C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CCSC)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N
分子式 C77H120N18O26S 分子量 1745.95
溶解度 ≥ 174.5mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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