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Rhodopsin peptide

目录号 GP10042

Pigment in retina photoreceptor cell;GPCR

规格 价格 库存 购买数量
1mg
¥840.00
现货
5mg
¥2,520.00
现货
10mg
¥4,200.00
现货
25mg
¥5,880.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Rhodopsin peptide,(C51H88N14O20), a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin, also known as visual purple, is a biological pigment in photoreceptor cells of the retina that is responsible for the first events in the perception of light. Rhodopsins belong to the G-protein-coupled receptor family and are extremely sensitive to light1. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. In general, the disease-causing protein aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network, and impairs the ability of the cell to degrade non-functioning proteins, which leads to photoreceptor apoptosis2. Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin. Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding3.

References:
1. Litmann BJ, Mitchell DC (1996). "Rhodopsin structure and function". In Lee AG. Rhodopsin and G-Protein Linked Receptors, Part A (Vol 2, 1996) (2 Vol Set).Greenwich,Conn: JAI Press. pp. 1-32.
2. Saliba RS, Munro PM, Luthert PJ, Cheetham ME (15 July 2002). "The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation". J. Cell. Sci. 115 (Pt 14): 2907-18.
3. Mendes HF, van der Spuy J, Chapple JP, Cheetham ME (April 2005). "Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy". Trends Mol Med 11 (4): 177-85.

Chemical Properties

Cas No. N/A SDF
别名 H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH
化学名 N/A
Canonical SMILES CC(C)C(N)C(NC(CO)C(NC(CCCCN)C(NC(C(O)C)C(NC(CCC(O)=O)C(NC(C(O)C)C(NC(CO)C(NC(C(NC(C(C)C)C(NC(C)C(N1C(C(NC(C)C(O)=O)=O)CCC1)=O)=O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C51H88N14O20 分子量 1217.33
溶解度 ≥ 121.7mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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