Home>>Large T antigen - rhesus polyomavirus 560-568

Large T antigen - rhesus polyomavirus 560-568 Sale

(Synonyms: H2N-Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile-OH ) 目录号 : GP10037

Large T antigen

Large T antigen - rhesus polyomavirus 560-568 Chemical Structure

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1mg
¥347.00
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5mg
¥1,040.00
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10mg
¥1,953.00
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25mg
¥2,573.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile.

T antigen is required for viral DNA replication, transcription, and virion assembly. In addition, T antigen targets multiple cellular pathways, including those that regulate cell proliferation, cell death, and the inflammatory response. The large T-antigen plays a key role in regulating the viral life cycle by binding to the viral origin of DNA replication where it promotes DNA synthesis. Also as the polyomavirus relies on the host cell machinery to replicate the host cell needs to be in s-phase for this to begin. Due to this, large T-antigen also modulates cellular signaling pathways to stimulate progression of the cell cycle by binding to a number of cellular control proteins.

Polyomaviruses have been extensively studied as tumor viruses in humans and animals, leading to fundamental insights into carcinogenesis, DNA replication and protein processing. The tumor suppressor molecule p53 was discovered, for example, as a cellular protein bound by the major oncoprotein (cancer-causing protein) T antigen made by Simian vacuolating virus 40 (SV40).

References:
1. An P, Saenz Robeles MT, Pipas JM. pLarge T antigens of polyomaviruses: amazing molecular machinesq. Annu Rev Microbiol. 2012; 66:213-36.
2. White MK, Gordon J, Reiss K, et al. (December 2005). "Human polyomaviruses and brain tumors". Brain Research. Brain Research Reviews 50 (1): 69-85.

Chemical Properties

Cas No. SDF
别名 H2N-Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile-OH
Canonical SMILES N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CO
分子式 C52H87N13O15 分子量 1134.33
溶解度 ≥ 113.4mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8816 mL 4.4079 mL 8.8158 mL
5 mM 0.1763 mL 0.8816 mL 1.7632 mL
10 mM 0.0882 mL 0.4408 mL 0.8816 mL
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