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Lamin fragment

目录号 GP10016

Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp

规格 价格 库存 购买数量
1mg
¥378.00
现货
5mg
¥1,176.00
现货
10mg
¥1,911.00
现货
25mg
¥2,541.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp.

The lamins are type V intermediate filaments which can be categorized as either A-type (lamin A, C) or B-type (lamin B1, B2) according to homology in sequence, biochemical properties and cellular localization during the cell cycle. Lamin polypeptides have an almost complete ǁ-helical conformation with multiple ǁ-helical domains separated by non-ǁ-helical linkers that are highly conserved in length and amino acid sequence.

Nuclear lamins are intermediate filament-type proteins that are the major building blocks of the nuclear lamina, a fibrous proteinaceous meshwork underlying the inner nuclear membrane. Lamins can also be localized in the nuclear interior, in a diffuse or spotted patter. Lamins also play roles in DNA replication, chromatin organization, spatial arrangement of nuclear pore complexes, nuclear growth, and anchorage of nuclear envelope proteins.

References:
1. The Cell: A Molecular Approach, Cooper & Hausman. 5th Edition. Pg. 357
2. Ayelet Margalit, Sylvia Vlcek, Yozef Gruenbaum, Roland Foisner (2005). Breaking and Making of the Nuclear Envelope. Journal of Cellular Biochemistry 95, 454-465
3. Bruce Alberts, et al. Molecular Biology of the Cell (4th edition). Garland Science 676-677
4. Geoffrey M. Cooper, Robert E. Hausman. The Cell, A Molecular Approach (4th edition). Sinauer Associates 356-360
5. Goldman et al.(2002). "Nuclear lamins: building blocks of nuclear architecture". Genes and Development 16,533-547
6. Joanna M. Bridger, Nicole Foeger, Ian R. Kill, Harald Herrmann (2007). The Nuclear Lamina: both a structural framework and a platform for genome organization. FEBS Journal 274, 1354-1361
7. Nico Stuurman, Susanne Heins, Ueli Aebi (1998). Nuclear Lamins: Their Structure, Assembly and Interactions. Journal of Structural Biology 122, 42-46
8. Tripathi K, Muralikrishna B and Parnaik VK (2009) Differential dynamics and stability of lamin A rod domain mutants IJIB, 5(1), 1-8
9. Yozef Gruenbaum, Katherine L. Wilson, Amnon Harel, Michal Goldberg, Merav Cohen (2000). Nuclear Lamins - Structural Proteins with fundamental functions. Journal of Structural Biology129, 313-323

Chemical Properties

Cas No. N/A SDF
别名 H2N-Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp-OH
化学名 N/A
Canonical SMILES NC(CCCCN)C(NC(C)C(NCC(NC(CCC(N)=O)C(NC(C(C)C)C(NC(C(C)C)C(NC(C(C)O)C(NC(C(C)CC)C(NC(CC1=CNC2=C1C=CC=C2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O
分子式 C47H76N12O12 分子量 1001.18
溶解度 ≥ 100.1mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

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