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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

  1. Cat.No. Product Name Information
  2. GC11847 (Z-Ala-Ala-Ala-Ala)2Rh110 fluorogenic elastase substrate
  3. GC11720 17-AAG (KOS953) Hsp90 inhibitor
  4. GC13044 17-DMAG (Alvespimycin) HCl Hsp90 inhibitor
  5. GC11553 2-cyano-Pyrimidine cathepsin K inhibitor
  6. GC11804 2-Guanidinoethylmercaptosuccinic Acid carboxypeptidase E inhibitor
  7. GC17937 2-MPPA glutamate carboxypeptidase II (GCP II) inhibitor
  8. GC13337 4-Chlorophenylguanidine hydrochloride Urokinase inhibitor, potent and specific
  9. GC11101 5-R-Rivaroxaban Factor Xa (FXa) inhibitor
  10. GC10258 Ac-IEPD-AFC Recognition motif for serine protease granzyme B
  11. GC10968 Ac-LEHD-AFC Fluorogenic caspase substrate
  12. GC12152 Acetyl-Calpastatin (184-210) (human) Calpain I/II inhibitor
  13. GC14502 AEBSF.HCl Serine protease inhibitor
  14. GC15130 Alogliptin (SYR-322)

    DPP-4 inhibitor,potent and highly selective

  15. GC13949 Alogliptin Benzoate DPP-4 inhibitor,selective and potent,antidiabetic drug
  16. GC14785 Alvelestat NE inhibitor
  17. GC14152 Amprenavir (agenerase)

    HIV-1 protease inhibitor

  18. GP10057 Amyloid β-Peptide (10-20) (human)

    Initiates neurodegeneration in Alzheimer disease

  19. GC14937 Anguizole Inhibitor of HCV replication
  20. GC13130 Apixaban

    Factor Xa inhibitor

  21. GC14209 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable

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