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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel(跨膜转运)

  1. Cat.No. 产品名称 Information
  2. GC61580 Sepimostat

    司匹司他,FUT-187 free base

     Sepimostat(FUT-187freebase)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostat抑制Ifenprodil结合的Ki值为27.7 µM。
  3. GC61570 Sepimostat dimethanesulfonate

    6-甲脒基萘-2-基4-((4,5-二氢-1H-咪唑-2-基)氨基)苯甲酸酯二甲磺酸盐,FUT-187

     Sepimostatdimethanesulfonate(FUT-187)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostatdimethanesulfonate抑制Ifenprodil结合的Ki值为27.7 µM。
  4. GC61565 Indophagolin

    5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺

     Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  5. GC61534 Charybdotoxin TFA CharybdotoxinTFA是一种含37个氨基酸的肽，可从蝎子Leiurusquinquestriatusvar.hebraeus中分离得到的。CharybdotoxinTFA是一个K+通道阻滞剂。
  6. GC61508 CALP2 TFA CALP2TFA是一种钙调蛋白(CaM)拮抗剂(Kd为7.9µM)，以亲和力结合CaMEF-hand/Ca2+结合位点。CALP2TFA抑制CaM依赖性磷酸二酯酶(phosphodiesterase)活性并增加细胞内Ca2+浓度。CALP2TFA有效抑制粘附和脱粒。CALP2TFA还是肺泡巨噬细胞的强激活剂。
  7. GC61493 Azumolene

    阿珠莫林,EU4093 free base

     A muscle relaxant
  8. GC61446 (Rac)-Lanicemine

    (Rac)-拉尼西明; (Rac)-AZD6765

     (Rac)-Lanicemine((Rac)-AZD6765)是Lanicemine的外消旋体。Lanicemine(AZD6765)是一种低捕获的NMDA受体拮抗剂，Ki为0.56-2.1 μM。CHO和爪蟾卵母细胞中，IC50分别为4-7μM和6.4μM。具有抗抑郁作用。
  9. GC61401 Oxatomide

    欧诗美锭

     Oxatomide是一种有效的具有口服活性的双重H1组胺受体(H1-histaminereceptor)和P2X7受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide几乎完全阻断人P2X7受体中ATP诱导的电流(IC50为0.95μM)。Oxatomide可抑制ATP诱导的Ca2+内流，IC50值为0.43μM，并且还抑制5-羟色胺(serotonin)。
  10. GC19729 Adenosine 5′-diphosphoribose sodium

    二磷酸腺苷核糖; ADP ribose sodium

     Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 代谢物。
  11. GC48843 5α-Androst-16-en-3α-ol

    (3α,5α)-16-烯-3-甾醇

     A pheromone with diverse biological activities
  12. GC48776 Olanzapine Lactam Impurity

    奥氮平内酰胺

     A potential impurity found in commercial preparations of olanzapine
  13. GC48715 ITH15004 A P2X7 receptor antagonist
  14. GC48550 Trimipramine-d3 (maleate)

    马来酸三甲丙咪嗪 d3 (马来酸盐)

     An internal standard for the quantification of trimipramine by GC- or LC-MS
  15. GC48432 KB-130015

    KB015

     An antiarrhythmic agent
  16. GC48395 3,3',5-Triiodo-L-thyronine (sodium salt hydrate)

    三碘代甲状腺素钠盐水合物; Triiodothyronine sodium hydrate; 3,3',5-Triiodo-L-thyronine sodium hydrate; T3 sodium hydrate

     A thyroid hormone
  17. GC48343 Gap19 (trifluoroacetate salt)

    KQIEIKKFK

     An inhibitor of Cx43 hemichannels
  18. GC48336 Tenapanor (hydrochloride)

    TENAPANORHCL(2盐),AZD1722 hydrochloride; RDX5791 hydrochloride

     A NHE-3 inhibitor
  19. GC50707 GX 201 GX 201 是一种选择性 NaV1.7 抑制剂，对 hNaV1.7 的 IC50 \u003c3.2 nM。
  20. GC50702 GoSlo SR 5-69 GoSlo SR 5-69 是一种有效的大电导 Ca2+- 激活 K+ (BK) 通道激活剂，EC50 为 251 nM。
  21. GC50678 NS 383 NS 383 是一种有效且独特的选择性大鼠 ASIC 抑制剂，含有 1a 和/或 3 个亚基。
  22. GC50670 D-GsMTx4 TRPC1/6 and Piezo2 inhibitor
  23. GC50667 SET 2 TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0
  24. GC50664 TRPV3 74a

    TRPV3 74a 是一种有效的选择性 TRPV3 拮抗剂。
  25. GC50661 BeKm 1

    通道阻滞剂多肽BEKM1

     BeKm 1 是一种 HERG（人类 ether-a-go-go 相关基因）阻断化合物。
  26. GC50649 FFN 200 dihydrochloride Selective fluorescent VMAT2 substrate
  27. GC48313 γ-Lindane

    林丹(R-六六六)

     An insecticide and GABAA receptor antagonist
  28. GC48262 YM-90K (hydrochloride hydrate) A neuropeptide with diverse biological activities
  29. GC48208 Tropisetron-d5 A neuropeptide with diverse biological activities
  30. GC48204 Trifluoperazine-d3 (hydrochloride)

    三氟拉嗪-D3盐酸盐

     An internal standard for the quantification of trifluoperazine
  31. GC48191 TPMPA (hydrate) 选择性 GABA\u003csub\u003eA\u003c/sub\u003e-ρ1 (ρ1 GABA\u003csub\u003eC\u003c/sub\u003e) 受体拮抗剂
  32. GC48159 TFB-TBOA (hydrate)

    CF3-Bza-TBOA

     EAAT1 和 EAAT2 抑制剂
  33. GC48149 Tetrabenazine-d7

    TBZ-d7

     A neuropeptide with diverse biological activities
  34. GC48094 Spiro-Oxanthromicin A A polyketide
  35. GC48021 Rabeprazole-d4 (sodium salt) A neuropeptide with diverse biological activities
  36. GC48013 PYD-106 A positive allosteric modulator of NR2C subunit-containing NMDARs
  37. GC48012 PtdIns-(4,5)-P2-fluorescein (triethylammonium salt) A neuropeptide with diverse biological activities
  38. GC47975 Prochlorperazine-d8 (hydrochloride) A neuropeptide with diverse biological activities
  39. GC47869 Pancuronium (bromide hydrate)

    NSC 293162

     An antagonist of muscle-type nAChRs
  40. GC47827 Ondansetron-13C-d3

    GR 38032-13C,d3; SN 307-13C,d3

     A neuropeptide with diverse biological activities
  41. GC47826 Omeprazole sulfone-d3

    OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3

     An internal standard for the quantification of omeprazole sulfone
  42. GC47778 Nitenpyram-d3 A neuropeptide with diverse biological activities
  43. GC47751 Nateglinide-d5

    那格列奈-D5,A4166 D5; Senaglinide D5

     An internal standard for the quantification of nateglinide
  44. GC47749 N-Arachidonoyl Taurine-d4 A neuropeptide with diverse biological activities
  45. GC47696 MNI-caged-L-glutamate (trifluoroacetate salt) A caged neurotransmitter used with photolysis
  46. GC47639 Metamizole-d3 (sodium salt)

    Dipyrone-d3

     A neuropeptide with diverse biological activities
  47. GC47601 Mastoparan (trifluoroacetate salt) A neuropeptide with diverse biological activities
  48. GC47537 Lansoprazole-d4

    兰索拉唑-D4,AG-1749-d4

     An internal standard for the quantification of lansoprazole
  49. GC47532 KUS121 A VCP modulator
  50. GC47478 JKE-1716 A GPX4 inhibitor
  51. GC47477 JKE-1674 A GPX4 inhibitor and active metabolite of ML-210

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