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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Proton Pump(质子泵)

Proton pump is a protein complex that transport the H+ ion across the membranes of lysosomes and vacuoles to generate an electrical and chemical gradient that provide energy for ATP synthesis from ADP.

Products for  Proton Pump

  1. Cat.No. 产品名称 Information
  2. GC69839 (R)-Tegoprazan

    (R)-CJ-12420; (R)-RQ-00000004

     (R)-Tegoprazan ((R)-CJ-12420; example 3) 是一种苯并咪唑衍生物，是一种有效的胃 H+/K+-ATP 酶抑制剂，对犬肾 Na+/K+-ATPase 的 IC50 为 98 nM。(R)-Tegoprazan 具有胃肠道疾病研究的潜力。
  3. GC25386 Ethacrynate Sodium

    ethacrynic acid sodium

     Ethacrynate Sodium (ethacrynic acid sodium) is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules.
  4. GC65377 Abeprazan hydrochloride

    DWP14012 hydrochloride; Fexuprazan hydrochloride

     Abeprazan (DWP14012) hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。
  5. GC64070 Omeprazole-d3-1

    奥美拉唑-D3,H 16868-d3-1

     An internal standard for the quantification of omeprazole
  6. GC63954 KM91104 KM 91104 is a cell-permeable inhibitor of V-ATPase that specifically targets the interaction between V-ATPase subunit a3 and subunit B2.
  7. GC63687 Rabeprazole-d4

    雷贝拉唑-D4,LY307640-d4

     An internal standard for the quantification of rabeprazole
  8. GC63472 Zastaprazan

    JP-1366

     Zastaprazan 是一种 proton pump 抑制剂 (WO2018008929)。Zastaprazan 可用于胃肠道炎症或胃酸相关疾病的研究。
  9. GC63335 Omeprazole-13CD3

    H 16868-13CD3

     Omeprazole-13CD3 (H 16868-13CD3) 是一种 13C 标记和氘代标记 Omeprazole。Omeprazole (H 16868) 是一种质子泵 (proton pump) 抑制剂 (PPI)，有潜力用于胃肠道疾病的研究。Omeprazole 竞争性抑制 CYP2C19 活性，Ki 为 2 到 6 μM。Omeprazole 还抑制革兰氏阳性菌和革兰氏阴性菌生长。Omeprazole 是中性鞘磷脂酶 (N-SMase) 的抑制剂(外泌体抑制剂)。
  10. GC62885 Caloxin 2A1 TFA Caloxin 2A1 TFA 是一种细胞外质膜 Ca2+-ATPase (PMCA) 肽抑制剂。Caloxin 2A1 TFA 不影响基础 Mg2+-ATPase 或 Na+-K+-ATPase。
  11. GC62823 Abeprazan

    非苏拉赞,DWP14012; Fexuprazan

     Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。
  12. GC61863 Verucopeptin Verucopeptin 是一种有效的 HIF-1 (IC50=0.22 µM) 抑制剂，可以降低 HIF-1 靶基因的表达和 HIF-1α 的蛋白水平。通过直接靶向 v-ATPase ATP6V1G 亚基 (但不靶向 ATP1V1B2 或 ATP6V1D)，Verucopeptin 强烈抑制 v-ATPase 活性。Verucopeptin 对耐药性癌细胞表现出抗肿瘤活性，常用作癌症相关研究。
  13. GC47537 Lansoprazole-d4

    兰索拉唑-D4,AG-1749-d4

     An internal standard for the quantification of lansoprazole
  14. GC61155 Omeprazole sodium

    奥美拉唑钠,H 16868 sodium

     An irreversible inhibitor of the gastric proton pump
  15. GC60975 Lansoprazole Sulfide D4

    兰索拉唑硫醚-D4

     LansoprazoleSulfideD4是LansoprazoleSulfide的氘代物。LansoprazoleSulfide是质子泵抑制剂Lansoprazole的活性代谢产物。LansoprazoleSulfide是一种口服活性抗结核药，细胞内的IC50值为0.59µM，肉汤中的IC50值为0.46µM。
  16. GC60929 Ilaprazole sodium

    艾普拉唑钠,IY-81149 sodium

     A gastric proton pump inhibitor
  17. GC60530 5-Hydroxylansoprazole

    5-羟基兰索拉唑,AG1908

     5-Hydroxylansoprazole(AG1908)是血浆中Lansoprazole的活性代谢产物。Lansoprazole由CYP2C19代谢形成5-Hydroxylansoprazole。Lansoprazole是一种胃质子泵(proton-pump)抑制剂，可有效研究各种消化系统疾病。
  18. GC39734 Diphyllin

    二叶草素

     A lignan with diverse biological activities
  19. GC39429 Rabeprazole Sulfide

    2-[[[4-(3-甲氧基丙氧基)-3-甲基吡啶-2-基]甲基]硫代]-1H-苯并咪唑

     An active metabolite of rabeprazole
  20. GC37920 Vonoprazan

    沃诺拉赞; TAK-438 free base

     A selective and reversible proton pump inhibitor
  21. GC37756 Tenatoprazole sodium

    泰妥拉唑钠,TU-199 sodium

     A proton pump inhibitor
  22. GC36848 Pantoprazole sodium hydrate

    泮托拉唑钠水合物; BY1023 sodium hydrate; SKF96022 sodium hydrate

     A proton pump inhibitor
  23. GC36847 Pantoprazole sodium

    泮托拉唑钠; BY1023 sodium; SKF96022 sodium

     A proton pump inhibitor
  24. GC36806 Omeprazole D3

    奥美拉挫 D3; H 16868-d3

     An internal standard for the quantification of omeprazole
  25. GC36009 Esomeprazole magnesium salt

    (S)-Omeprazole magnesium salt; (-)-Omeprazole magnesium salt

     An H+/K+-ATPase inhibitor
  26. GC35982 EN6 An activator of autophagy
  27. GC33575 Esomeprazole potassium salt ((S)-Omeprazole potassium)

    艾美拉唑钾盐,(S)-Omeprazole potassium salt; (-)-Omeprazole potassium salt

     An H+/K+-ATPase inhibitor
  28. GC32924 Linaprazan (AZD0865)

    利那拉生; AZD0865

     An H+/K+-ATPase inhibitor
  29. GC32250 Chebulinic acid

    诃子林鞣酸

     An ellagitannin with diverse biological activities
  30. GC31987 S3337 S3337是一种H+，K+-ATPase抑制剂。
  31. GC31969 Pumaprazole (BY-841)

    BY-841

     Pumaprazole (BY-841) 是一种可逆的质子泵拮抗剂。
  32. GC31566 Tegoprazan

    特戈拉赞

    A proton pump inhibitor
  33. GC31466 Picoprazole

    吡考拉唑

     Picoprazole是一种特异性的H+/K+-ATPase抑制剂，IC50为3.1±0.4μM。
  34. GC31426 Bamaquimast (F 10126)

    F 10126; L 0042

     Bamaquimast (F 10126) (F 10126; L 0042) 是一种有效的平喘药。
  35. GC31347 Ilaprazole (IY-81149)

    艾普拉唑; IY-81149

     A gastric proton pump inhibitor
  36. GC30418 SKF96067 SKF96067是一种可逆的H+/K+-ATPase抑制剂。
  37. GC30130 Soraprazan (BYK61359)

    BYK61359

    Soraprazan (BYK61359) (BYK61359) 是一种选择性的、可逆的 K 竞争性 H,K-ATPase 抑制剂 (Ki=6.4 nM)，在胃腺中的 IC50 为 0.19 μM。
  38. GC15334 N2-Methyl-L-arginine Selective L-arginine uptake inhibitor
  39. GC11151 SCH 28080 An inhibitor of H+/K+-ATPases
  40. GC16516 BCH

    2-氨基-2-去甲菠烷羧酸,2-amino-2-Norbornanecarboxylic Acid

     An inhibitor of LAT1
  41. GC12718 Pantoprazole

    泮托拉唑; BY1023; SKF96022

     A proton pump inhibitor
  42. GC16645 Rabeprazole

    雷贝拉唑; LY307640

     雷贝拉唑 (LY307640) 是第二代质子泵抑制剂 (PPI)，可不可逆地灭活胃 H+/K+-ATPase。
  43. GC15670 Rabeprazole sodium

    雷贝拉唑钠; LY307640 sodium

     A proton pump inhibitor
  44. GC14313 Esomeprazole Magnesium

    埃索美拉唑镁,(S)-Omeprazole magnesium; (-)-Omeprazole magnesium

     A form of esomeprazole in complex with magnesium
  45. GC16453 Zinc Pyrithione

    吡啶硫酮锌

     A coordination complex of zinc and pyrithione
  46. GC16622 Dexlansoprazole

    右旋兰索拉唑; Dexlansoprazole

     A proton pump inhibitor
  47. GC10599 Esomeprazole Sodium

    埃索美拉唑钠,(S)-Omeprazole sodium; (-)-Omeprazole sodium

    An H+/K+-ATPase inhibitor
  48. GC12112 Lansoprazole sodium

    兰索拉唑钠

     Proton pump inhibitor
  49. GC17519 Concanamycin A

    刀豆素A; Antibiotic X 4357B; Folimycin; X 4357B

    A plecomacrolide antibiotic
  50. GC17597 Bafilomycin A1

    巴佛洛霉素A1; BafA1

    A fungal metabolite with diverse biological activities
  51. GC15418 TAK-438

    富马酸沃诺拉赞

     A selective and reversible proton pump inhibitor

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