γ-Lindane
(Synonyms: 林丹(R-六六六)) 目录号 : GC48313
An insecticide and GABAA receptor antagonist
Cas No.:58-89-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.1 It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).2,3 It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).4 γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).5 It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.4,6
1.Obata, T., Yamamura, H.I., Malatynska, E., et al.Modulation of ?-aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsantsJ. Pharmacol. Exp. Ther.244(3)802-806(1988) 2.Hainzl, D., Cole, L.M., and Casida, J.E.Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproductChem. Res. Toxicol.11(12)1529-1535(1998) 3.Llorens, J., SuÑol, C., Tussel, J.M., et al.Lindane inhibition of [35S]TBPS binding to the GABAA receptor in rat brainNeurotoxicol. Teratol.12(6)607-610(1990) 4.Ratra, G.S., Kamita, S.G., and Casida, J.E.Role of human GABAA receptor β3 subunit in insecticide toxicityToxicol. Appl. Pharmacol.172(3)233-240(2001) 5.Ihara, M., Ishida, C., Okuda, H., et al.Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and ?-hexachlorocyclohexane (?-HCH) on ?-aminobutyric acid- and glutamate-induced responses of American cockroach neuronsInvert. Neurosci.5(3-4)157-164(2005) 6.Meinking, T.L., Taplin, D., Kalter, D.C., et al.Comparative efficacy of treatments for pediculosis capitis infestationsArch. Dermatol.122(3)267-271(1986)
| Cas No. | 58-89-9 | SDF | |
| 别名 | 林丹(R-六六六) | ||
| Canonical SMILES | Cl[C@@H]1[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl | ||
| 分子式 | C6H6Cl6 | 分子量 | 290.8 |
| 溶解度 | Chloroform: 50 mg/ml,Ethanol: >1 mg/ml,Methanol: >1 mg/ml,Water: 8.35 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4388 mL | 17.1939 mL | 34.3879 mL |
| 5 mM | 0.6878 mL | 3.4388 mL | 6.8776 mL |
| 10 mM | 0.3439 mL | 1.7194 mL | 3.4388 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。