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P2X purinergic receptor(P2X嘌呤受体)

P2X purinergic receptor is a famliy of ATP-gated cation channels. It is widely distributed in the body and paly an important role in regulation of synaptic transmission, vascular endothelium and nociception etc.

  1. Cat.No. 产品名称 Information
  2. GC67895 EVT-401
  3. GC64822 JNJ-42253432
  4. GC63996 Lu AF27139
  5. GC63838 GSK-1482160
  6. GC63444 Filapixant
  7. GC62950 Eliapixant Eliapixant (BAY1817080) is a highly potent and selective P2X3 receptor antagonist with a mean IC50 of 8 nM.
  8. GC62560 (E/Z)-Sivopixant
  9. GC62284 JNJ-55308942
  10. GC61565 Indophagolin Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  11. GC61401 Oxatomide
  12. GC60281 P2X3 antagonist 34
  13. GC60090 BLU-5937
  14. GC39699 Aurintricarboxylic acid A protein synthesis inhibitor with diverse biological activities
  15. GC50474 A 317491 sodium salt A P2X3 and P2X2/3 receptor antagonist
  16. GC50200 BX 430 A P2X4 receptor antagonist
  17. GC36613 Minodronic acid Minodronic acid (YM529, ONO-5920) is a third-generation nitrogen-cotaining bisphosphonate that is used for the treatment of osteoporosis. Minodronic acid is an aminobisphosphonate that is a selective antagonist of purinergic P2X2/3 receptors involved in pain.
  18. GC36202 GW791343 dihydrochloride
  19. GC35567 Bullatine A
  20. GC35211 A-317491 sodium salt hydrate A P2X3 and P2X2/3 receptor antagonist
  21. GC43931 JNJ-47965567 A selective P2X7 antagonist
  22. GC31674 AZD9056 hydrochloride
  23. GC31157 CE-224535 (PF-04905428)
  24. GC30805 PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine)
  25. GC19422 Gefapixant Gefapixant 是一种具有口服活性的强效嘌呤能 P2X3 受体 (P2X3R) 拮抗剂,与重组 hP2X3 同源三聚体相比,IC50 值约为 30 nM,对 hP2X2/3 异源三聚体受体的 IC50 值为 100-250 nM。
  26. GC19022 AF-353 A dual P2X3 and P2X2/3 receptor antagonist
  27. GC12421 Brilliant Blue G A dye for staining or quantifying proteins
  28. GC17870 A 804598 A potent and selective competitive antagonist of the P2X7 receptor
  29. GC16330 Ro 51 Ro 51 是一种有效的选择性双重 P2X3/P2X2/3 拮抗剂,对 P2X3 和 P2X2/3 的 IC50 分别为 2 nM 和 5 nM。
  30. GC11682 TC-P 262 TC-P 262 是一种有效的 P2X3 抑制剂。
  31. GC17375 AZ 10606120 dihydrochloride A P2X7 receptor antagonist
  32. GC13943 5-BDBD 5-BDBD 是一种有效的选择性 P2X4 受体拮抗剂,可抑制 rP2X4R 介导的电流,IC50 为 0.75 μM。
  33. GC18052 AZ 11645373 Human P2X7 antagonist,potent and selective
  34. GC13224 NF 110 NF 110 是一种 P2X3 受体拮抗剂 (Ki \u003d 36 nM),对稳定表达的 P2Y 受体无活性 (IC50s \u003e 10 M)。
  35. GC17320 NF 157 NF 157 是一种高度选择性的纳摩尔 P2Y11 拮抗剂,pKi 为 7.35。
  36. GC11216 Ro 0437626

    Ro 0437626 是一种选择性嘌呤能 (P2X1) 受体拮抗剂 (IC50 = 3 μM),但对 P2X2、P2X3 和 P2X2/3 受体的亲和力较低 (IC50 > 100 μM)。

  37. GC11326 NF 449

    A potent P2X1 receptor antagonist

  38. GC16342 PPNDS PPNDS 是一种选择性和竞争性的 meprin ⋲;抑制剂 (IC50: 80 nM, Ki: 8 nM),并且还抑制 ADAM10 (IC50: 1.2 μM)。
  39. GC11289 NF 023 A P2X1 receptor antagonist
  40. GC10411 MRS 2219 P2X1 receptor potentiator
  41. GC14992 NF 279 NF 279 是一种有效的选择性和可逆的 P2X1 受体拮抗剂,IC50 为 19 nM。
  42. GC10990 iso-PPADS tetrasodium salt P2 purinoceptors antagonist, specific
  43. GC16659 PPADS tetrasodium salt A non-selective P2-purinoceptor antagonist
  44. GC13584 Purotoxin 1 P2X3 receptor modulator
  45. GC12574 ATPγS tetralithium salt A non-hydrolyzable ATP analog
  46. GC15898 BzATP triethylammonium salt An activator of P2X purinergic receptors
  47. GC10152 RO-3 A dual P2X3 and P2X2/3 receptor antagonist
  48. GC17355 TNP-ATP triethylammonium salt An antagonist of P2X1, P2X3, and P2X2/3 receptors and a fluorescent probe
  49. GC16832 Suramin hexasodium salt A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities
  50. GC15416 2-Methylthioadenosine triphosphate tetrasodium salt 2-Methylthioadenosine triphosphate tetrasodium salt 是一种非特异性 P2 受体激动剂。
  51. GC14207 GW791343 HCl GW791343 HCl 是一种有效的人 P2X7 受体负变构调节剂(表现出物种特异性活性),对人 P2X7 受体产生非竞争性拮抗作用,pIC50 为 6.9-7.2。

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