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(E/Z)-Sivopixant

目录号 : GC62560

(E/Z)-Sivopixant (Compound I-127) 是一种有效的 P2X3 受体拮抗剂,IC50 为 4 nM。(E/Z)-Sivopixant 可用于呼吸系统疾病研究。

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥4,527.00
现货
5 mg
¥4,050.00
现货
10 mg
¥7,200.00
现货
25 mg
¥14,850.00
现货
50 mg
¥22,950.00
现货
100 mg
¥34,200.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

(E/Z)-Sivopixant (Compound I-127) is a potent P2X3 receptor antagonist with an IC50 of 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research[1].

ATP receptors are roughly classified into an ion channel type P2X family and a G protein coupled type P2Y family. Seven types of subtypes have been reported in the P2X receptor family, and function as non-selective cation channels by forming homotrimers or heterotrimers with other P2X subtypes. Furthermore, P2X3 that the receptor is expressed in neuroepithelial bodies (NEB) of the lungs, and ATP-induced cough, etc., P2X3 receptors It has been suggested that it is involved in information transmission in the respiratory organs[1].

[1]. Kai, Hiroyuki, et al. Amino-triazine derivatives and pharmaceutical composition containing said derivatives. WO2014200078A1.

Chemical Properties

Cas No. 1640808-39-4 SDF
别名 (E/Z)-S-600918
化学名 N/A
Canonical SMILES N/A
分子式 C25H22ClN5O5 分子量 507.93
溶解度 DMSO : 100 mg/mL (196.88 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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