Home>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>A-317491 sodium salt hydrate

A-317491 sodium salt hydrate Sale

目录号 : GC35211

A P2X3 and P2X2/3 receptor antagonist

A-317491 sodium salt hydrate Chemical Structure

规格 价格 库存 购买数量
Free Sample (0.1-0.5 mg) 待询 待询
5mg
¥854.00
现货
10mM (in 1mL Water)
¥1,139.00
现货
50mg
¥4,302.00
现货
100mg 待询 待询
200mg 待询 待询

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

A-317491 is a non-nucleotide antagonist of the purinergic receptors P2X3 and P2X2/3 (Kis = 22-92 nM in a calcium influx assay) that is selective over other purinergic and neurotransmitter receptors, ion channels, and enzymes (IC50s = >10 ?M).1 It reduces thermal hyperalgesia induced by complete Freund’s adjuvant in rats (ED50 = 30 ?mol/kg, s.c.) and nociceptive responses to chemically-induced pain. Chronic administration of A-317491 (30 ?mol/kg, twice daily) reduces early, but not late, phase pain in a mouse model of bone cancer.2 A-317491 does not readily cross the blood-brain barrier and reduces pain responses when applied topically in a rat model of inflammatory pain, indicating that it acts primarily at peripheral purinergic receptors.3

1.Jarvis, M.F., Burgard, E.C., McGaraughty, S., et al.A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the ratProc. Natl. Acad. Sci. USA99(26)17179-17184(2002) 2.Hansen, R.R., Nasser, A., Falk, S., et al.Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in miceEur. J. Pharmacol.688(1-3)27-34(2012) 3.Wu, G., Whiteside, G.T., Lee, G., et al.A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in ratsEur. J. Pharmacol.504(1-2)45-53(2004)

Chemical Properties

Cas No. SDF
Canonical SMILES O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O.[Na].O
分子式 C33H29NNaO9 分子量 606.57
溶解度 Water: ≥ 100 mg/mL (164.86 mM); DMSO: ≥ 100 mg/mL (164.86 mM) 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 1.6486 mL 8.2431 mL 16.4861 mL
5 mM 0.3297 mL 1.6486 mL 3.2972 mL
10 mM 0.1649 mL 0.8243 mL 1.6486 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置