p-Dimethylaminobenzaldehyde
(Synonyms: 对二甲胺基苯甲醛,4-Dimethylaminobenzaldehyde) 目录号 : GC39786
p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) 是多见于 Ehrlich's 和 Kovac's 试剂中用于检测吲哚的一种含胺和醛的化合物。
Cas No.:100-10-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles[1].
[1]. Axel Ehmann, et al. The van URK-Salkowski reagent — a sensitive and specific chromogenic reagent for silica gel thin-layer chromatographic detection and identification of indole derivatives. Journal of Chromatography A. Volume 132, Issue 2, 11 February 1977, Pages 267-276.
| Cas No. | 100-10-7 | SDF | |
| 别名 | 对二甲胺基苯甲醛,4-Dimethylaminobenzaldehyde | ||
| Canonical SMILES | O=CC1=CC=C(N(C)C)C=C1 | ||
| 分子式 | C9H11NO | 分子量 | 149.19 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.7029 mL | 33.5143 mL | 67.0286 mL |
| 5 mM | 1.3406 mL | 6.7029 mL | 13.4057 mL |
| 10 mM | 0.6703 mL | 3.3514 mL | 6.7029 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
p-Dimethylaminobenzaldehyde-based chemosensor for on-site sensing of ammonia precursor in concrete
Spectrochim Acta A Mol Biomol Spectrosc 2021 May 15;253:119556.PMID:33611218DOI:10.1016/j.saa.2021.119556.
A chemosensor for on-site sensing of ammonia precursor in concrete to avoid a problem of ammonia emission into the indoor space of concrete buildings was designed and implemented. It was found that aqueous extracts of concrete samples containing antifreeze additives and excreting ammonia were colored in the presence of p-Dimethylaminobenzaldehyde. This phenomenon was used for the fast visual sensing of main ammonia precursor (urea) in concrete for the first time. The developed sensor consisted of a sensing solid phase based on an adsorbent modified with p-Dimethylaminobenzaldehyde. Various adsorbents were investigated for the immobilization of the reagent and it was established that silica adsorbent Silochrom C-120 provided effective retention of the reagent and Schiff's base formation during the sampling. Moreover, Silochrom C-120 modified with ascorbic acid was proposed to eliminate the oxidant interference. The sensor displayed excellent selectivity and sensitivity with the visual detection limit of 15 mg kg-1 in terms of urea. The chemosensor was successfully applied by builders on different construction sites. Sample preparation and sensing times were about 2 min and 1 min, respectively.
p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence
Biochim Biophys Acta 2000 Nov 15;1502(3):398-404.PMID:11068182DOI:10.1016/s0925-4439(00)00064-8.
In the present work, pepsin digests of tail tendons from streptozotocin-diabetic rats were found to contain material that reacted rapidly at room temperature with p-Dimethylaminobenzaldehyde (Ehrlich's reagent) to give an adduct with an absorbance spectrum characteristic of the Ehrlich chromogen of pyrrolic nature determined in ageing collagens. A significant correlation of the Ehrlich adduct with tendon mechanical strength and collagen fluorescence characteristic of advanced glycation endproducts was observed. Collagen content of the Ehrlich-positive material was found to be significantly elevated in tendons of diabetic rats compared with age-matched healthy controls. The results indicate that the p-dimethylaminobenzaldehyde-reactive pyrrole moieties may contribute to the increased cross-linking of diabetic matrix collagen. Profound inhibitory effect of aminoguanidine was observed, underlining the role of non-enzymatic mechanisms of advanced glycation in pyrrolisation and cross-linking of collagen exposed to hyperglycaemia. It is hypothesised that quantification of the p-dimethylaminobenzaldehyde-reactive material in matrix collagen may provide a tissue measure of integrated hyperglycaemia over prolonged periods of time. Further research is to assess the significance of p-dimethylaminobenzaldehyde-reactive substances in diabetic collagen tissues and to reveal their relationship to enzyme-mediated physiological pyrrolisation of ageing collagens.
p-Dimethylaminobenzaldehyde thiosemicarbazone: a simple novel selective and sensitive fluorescent sensor for mercury(II) in aqueous solution
Talanta 2006 Mar 15;69(1):103-6.PMID:18970539DOI:10.1016/j.talanta.2005.09.015.
A novel and simple fluorophore, p-Dimethylaminobenzaldehyde thiosemicarbazone (DMABTS), was prepared in order to find available fluorescent chemosensor for mercuric ion in aqueous solution. DMABTS emitted fluorescence at 448 nm in aqueous solution and its fluorescence intensity was completely quenched upon interaction with Hg(2+) ions, which should be attributed to the 1:1 complex formation between DMABTS and Hg(2+). The binding constant of the complex was determined as 7.48 x 10(6)mol l(-1). The linear range of quantitative detection of 0 to 5.77 x 10(-6)mol l(-1) and the detection limit of 7.7 x 10(-7)mol l(-1) for Hg(2+) in the 6.3 x 10(-6)mol l(-1) DMABTS aqueous solution were obtained from a calibration curve. The coexistence of several transition metal ions and anions did interfere the fluorometric titration of Hg(2+) ion by less than 4% in the emission change.
Vapor-phase staining of cyanoacrylate-fumed latent fingerprints using p-Dimethylaminobenzaldehyde
J Forensic Sci 2012 Mar;57(2):515-20.PMID:22103265DOI:10.1111/j.1556-4029.2011.01976.x.
Contrasting or enhancing of cyanoacrylate ester-fumed latent fingerprints deposited on solvent-sensitive materials such as oil marker writings and rough surface materials such as unglazed earthenware is not easy by conventional dye solutions dipping or dye powder dusting. In this study, a new vapor-phase staining method using p-Dimethylaminobenzaldehyde (DMAB) is proposed for staining such materials. DMAB has high volatility and selective absorbability to cyanoacrylate-fumed fingerprints, so that cyanoacrylate-treated samples can be easily stained by leaving them simply in a closed container along with DMAB crystals for 48-96 h at room temperature or in conjunction with the use of mild heating. The stained fingerprint could be excited by UV irradiation (365 nm), and the fluorescent fingerprint was photographed through a UV cut-off filter (420 nm). The new method achieved minimally destructive fluorescent staining for the solvent-sensitive samples and the rough surfaced samples.
A new approach to the spectrophotometric determination of metronidazole and tinidazole using p-Dimethylaminobenzaldehyde
Acta Pharm 2009 Dec;59(4):407-19.PMID:19919930DOI:10.2478/v10007-009-0039-2.
A new approach to the spectrophotometric determination of metronidazole (MZ) and tinidazole (TZ) has been developed. The procedure involves coupling of diazotized nitroimidazoles with p-Dimethylaminobenzaldehyde (DMAB) to form a greenish-yellow solution. Optimal temperature and time were 0 degrees C (iced) and 3 minutes for diazotization and 30 degrees C and 2 minutes for coupling for both MZ and TZ. Coloured adducts of MZ and TZ showed shoulders at 406 nm and 404 nm, respectively, which were selected as analytical wavelengths. The reaction with p-DMAB occurred in a 1:1 mole ratio. Beer's law was obeyed within the 4.8-76.8 microg mL(-1) concentration range with low limits of detection. The azo adducts were stable for over a week. Molar absorptivities were 1.10 x 10(3) (MZ) and 1.30 x 10(3) L mol(-1) cm(-1) (TZ). Overall recoveries of MZ and TZ from quality control samples were 103.2 + or - 1.3 and 101.9 + or - 1.3% over three days. There was no interference from commonly utilized tablet excipients. No significant difference was obtained between the results of the new method and the BP titrimetric procedures. The azo approach using the p-Dimethylaminobenzaldehyde procedure described in this paper is simple, fast, accurate and precise. It is the first application of DMAB as a coupling component in the diazo coupling reaction.