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EVT-401

(Synonyms: P2X7 receptor antagonist-1) 目录号 : GC67895

EVT-401 (P2X7 receptor antagonist-1) 是一种嘌呤能 P2X7 受体拮抗剂。EVT-401 具有抗神经炎症的作用。

EVT-401 Chemical Structure

规格 价格 库存 购买数量
10mg
¥7,650.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

EVT-401 (P2X7 receptor antagonist-1) is a purinergic P2X7 receptor antagonist. EVT-401 has efficacy of combating neuroinflammation[1].

[1]. Binan Zhu, et al. Identification and characterization of related substances in EVT-401 by hyphenated LC-MS techniques. J Pharm Anal

Chemical Properties

Cas No. SDF Download SDF
别名 P2X7 receptor antagonist-1
分子式 C22H20F4N2O3 分子量 436.4
溶解度 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.2915 mL 11.4574 mL 22.9148 mL
5 mM 0.4583 mL 2.2915 mL 4.583 mL
10 mM 0.2291 mL 1.1457 mL 2.2915 mL
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Research Update

Identification and characterization of related substances in EVT-401 by hyphenated LC-MS techniques

J Pharm Anal 2017 Aug;7(4):223-230.PMID:29404042DOI:PMC5790700

A sensitive and selective method was developed for the separation and characterization of related substances (RSs) in EVT-401 by hyphenated LC-MS techniques. Complete separation of the RSs was achieved with an Inertsil ODS-SP column (250 mm×4.6 mm, 5 µm) by linear gradient elution using a mobile phase consisting of 0.2% formic acid solution, methanol and acetonitrile. EVT-401 was found to be susceptible to acid, alkaline and oxidative stresses, while relatively stable under photolytic and thermal dry stress conditions. Fourteen RSs including six process-related substances and eight degradation products were detected and identified in EVT-401 with positive ESI high-resolution TOF-MS analysis of their parent ions and the corresponding product mass spectra elucidation, and some of them were further verified by chemical synthesis and NMR spectroscopy. The specific LC-MS method developed for separation, identification and characterization of RSs is valuable for EVT-401 manufacturing process optimization and quality control.