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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel(跨膜转运)

  1. Cat.No. 产品名称 Information
  2. GC49326 5β-Dihydroprogesterone A progesterone receptor agonist and metabolite of progesterone
  3. GC49306 Isopimaric Acid A diterpenoid resin acid
  4. GC49296 τ-Fluvalinate A pyrethroid acaricide
  5. GC49291 rac-N-desmethyl Ivabradine-d6 (hydrochloride) An internal standard for the quantification of N-desmethyl ivabradine
  6. GC49290 Indoxyl Sulfate-d5 (potassium salt) An internal standard for the quantification of indoxyl sulfate
  7. GC49278 Fenpropathrin A pyrethroid insecticide
  8. GC49258 Picaridin-d3 An internal standard for the quantification of picaridin
  9. GC49255 GYKI 52466 (hydrochloride) An allosteric AMPA receptor antagonist
  10. GC49252 4’-hydroxy Trazodone A metabolite of trazodone
  11. GC49250 Hydroxydehydro Nifedipine Carboxylate A metabolite of nifedipine
  12. GC49249 O-Desmethyl Lacosamide A potential impurity found in commercial preparations of lacosamide
  13. GC49242 Descarbonyl Lacosamide A potential impurity found in commercial preparations of lacosamide
  14. GC49231 Adenylosuccinic Acid (ammonium salt) A purine nucleotide and an intermediate in the purine nucleotide cycle
  15. GC49217 Trifluoperazine N-Glucuronide A metabolite of trifluoperazine
  16. GC49213 trans-hydroxy Glimepiride An active metabolite of glimepiride
  17. GC49212 trans-carboxy Glimepiride A metabolite of glimepiride
  18. GC49204 Nefazodone-d6 (hydrochloride) An internal standard for the quantification of nefazodone
  19. GC49194 Metolazone-d7 An internal standard for the quantification of metolazone
  20. GC49191 Chlorzoxazone-d3 An internal standard for the quantification of chlorzoxazone
  21. GC49184 Palonosetron N-oxide A metabolite of palonosetron
  22. GC49140 α-Conotoxin ImI (trifluoroacetate salt) A conotoxin and an antagonist of α7 nAChRs
  23. GC49133 N-hydroxy Riluzole A metabolite of riluzole
  24. GC49129 Diphenidol-d10 An internal standard for the quantification of diphenidol
  25. GC49102 Flavoxate-d5 An internal standard for the quantification of flavoxate
  26. GC49097 α-Conotoxin AuIB (trifluoroacetate salt) A conotoxin and an antagonist of α3β4 subunit-containing nAChRs
  27. GC49095 Olanzapine-related Compound B A potential impurity found in commercial preparations of olanzapine
  28. GC49090 Nilvadipine-d4 An internal standard for the quantification of nilvadipine
  29. GC49089 FR900359 A cyclic depsipeptide and an inhibitor of Gαq, Gα11, and Gα14
  30. GC49086 Nicorandil-d4 An internal standard for the quantification of nicorandil
  31. GC49056 Dolasetron-d4 An internal standard for the quantification of dolasetron
  32. GC49033 Guanosine 5’-diphosphate (sodium salt hydrate) A purine nucleotide
  33. GC49025 Desogestrel-13C2-d2 An internal standard for the quantification of desogestrel
  34. GC49017 8-hydroxy Amoxapine A metabolite of amoxapine
  35. GC48998 β-Defensin-1 (human) (trifluoroacetate salt) An antimicrobial peptide
  36. GC48984 Esomeprazole An H+/K+-ATPase inhibitor
  37. GC48979 Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate) A substrate of multidrug resistance protein 2
  38. GC62641 WEHI-9625 WEHI-9625 是一种首创的，三环砜小分子凋亡抑制剂，EC50 值为 69 nM。WEHI-9625 与 VDAC2 结合可促进其抑制小鼠 BAK 诱导的细胞凋亡的能力，但对人 BAK 和与凋亡效应密切相关的 BAX 因子均完全无效。
  39. GC62560 (E/Z)-Sivopixant (E/Z)-Sivopixant (Compound I-127) 是一种有效的 P2X3 受体拮抗剂，IC50 为 4 nM。(E/Z)-Sivopixant 可用于呼吸系统疾病研究。
  40. GC62522 Posenacaftor sodium Posenacaftor (PTI-801) sodium 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂，可纠正 CFTR 蛋白的折叠和运输。Posenacaftor sodium 用于囊性纤维化 (CF) 的研究。
  41. GC62513 (R)-Posenacaftor sodium (R)-Posenacaftor (R)-PTI-801) sodium 是 Posenacaftor 的 R 对映异构体。Posenacaftor (PTI-801) 是一种囊性纤维化跨膜调节蛋白 (CFTR) 调节剂，可纠正 CFTR 蛋白的折叠和运输。Posenacaftor 用于囊性纤维化 (CF) 的研究。
  42. GC62510 CFTR corrector 6 CFTR corrector 6 是有效的囊性纤维化跨膜电导调节剂 (CFTR) 增强剂。CFTR corrector 6 有潜力用于囊性纤维化 (CF) 和其他 CFTR 相关疾病的研究。
  43. GC62284 JNJ-55308942 JNJ-55308942 是一种高亲和力、选择性、可透过血脑屏障的 P2X7 功能拮抗剂 (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM)。JNJ-55308942 口服生物利用度高，可与大脑 P2X7 结合并阻断 IL-1β 从成年啮齿动物脑中释放。
  44. GC62196 Nisoldipine-d7 Nisoldipine-d7 是 Nisoldipine 的氘代物。Nisoldipine(BAY-k 5552)是高效特异的 L 型 Cav1.2 通道阻断剂，IC50 为 10 nM。
  45. GC62179 Cyclic ADP-ribose An endogenous Ca2+ mobilizer
  46. GC62163 VU041 VU041 是第一个亚微摩尔亲和力 Anopheles (An.) gambiae 和 Aedes (Ae.) aegypti Kir1 通道的抑制剂，IC50 值分别为 2.5 μM 和 1.7 μM。VU041 明显抑制哺乳动物 Kir2.1 通道 (IC50 为12.7 μM)，对哺乳动物 Kir1.1，Kir4.1，Kir6.2/SUR1 和 Kir7.1 的抑制作用较小。VU041 也可导致 Malpighian 小管功能受损。
  47. GC62067 ω-Conotoxin GVIA TFA

    ω-Conotoxin GVIA TFA 是一种 N 型钙通道 (Ca2+ channel) 抑制剂。
  48. GC61963 Caroverine hydrochloride Caroverine hydrochloride 是一种有效，竞争性和可逆的 NMDA 和 AMPA 谷氨酸受体拮抗剂。Caroverine hydrochloride 也是一种抗氧化剂和钙阻断剂，具有血管舒张作用。Caroverine hydrochloride 可用于内耳耳鸣的研究。
  49. GC61960 ASP2905 ASP2905 是由 Kcnh3/BEC1 基因编码的有效且选择性的钾通道 Kv12.2 抑制剂。ASP2905 可以穿越血脑屏障并具有抗精神病活性。
  50. GC61933 Propiverine hydrochloride A muscarinic acetylcholine receptor antagonist
  51. GC61898 1,2,4-Trihydroxybenzene 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) 是咖啡豆烘焙的副产物，可增加大鼠胸腺淋巴细胞中 Ca2+ 浓度。

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