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Propofol-d18 Sale

(Synonyms: 异丙酚 d18) 目录号 : GC65057

Propofol-d18 是 Propofol 的氘代物。Propofol 有效直接地激活 GABAA 受体和抑制谷氨酸受体介导的兴奋性突触传递。

Propofol-d18 Chemical Structure

Cas No.:1189467-93-3

规格 价格 库存 购买数量
1mg
¥1,260.00
现货
5mg
¥2,475.00
现货
10mg
¥3,960.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Propofol-d18 is the deuterium labeled Propofol. Propofol potently and directly activates GABAA receptor and inhibits glutamate receptor mediated excitatory synaptic transmission[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. R Nadeson, et al. Antinociceptive Properties of Propofol: Involvement of Spinal Cord Gamma-Aminobutyric acid(A) Receptors. J Pharmacol Exp Ther . 1997 Sep;282(3):1181-6.

Chemical Properties

Cas No. 1189467-93-3 SDF Download SDF
别名 异丙酚 d18
分子式 C12D18O 分子量 196.38
溶解度 DMSO : 50 mg/mL (254.61 mM; Need ultrasonic) 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 5.0922 mL 25.4608 mL 50.9217 mL
5 mM 1.0184 mL 5.0922 mL 10.1843 mL
10 mM 0.5092 mL 2.5461 mL 5.0922 mL
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Research Update

Quantification of remifentanil and propofol in human plasma: a LC-MS/MS assay validated according to the EMA guideline

Bioanalysis 2015;7(13):1675-84.PMID:26226314DOI:10.4155/bio.15.89

Background: Remifentanil and propofol are often used in combination for general anesthesia. We developed a method using LC-MS for their simultaneous measurement in human plasma. Methodology & results: After addition of remifentanil-(13)C6 and Propofol-d18 (IS), 500 µl of plasma were extracted with ethylacetate/hexane. Analysis conditions included gradient elution (water/acetonitrile), electrospray ionization and detection with a triple quadripole mass spectrometer. Remifentanil and propofol were ionized in the positive and negative mode, respectively. The method was validated according to the European Medicines Agency guideline for the validation of bioanalytical methods, then successfully applied to clinical samples from three patients who had undergone liver transplantation. Conclusion: This method is suitable for the simultaneous quantification of remifentanil and propofol in clinical studies.