Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC10008 GSK1070916
GSK-1070916A
A potent inhibitor of Aurora B and C kinases
GC13332 Aurora A Inhibitor I A potent and selective inhibitor of Aurora A kinase
GC15106 CYC116 A potent Aurora kinase inhibitor
GC11085 TAK-901
5-[3-(乙基磺酰基)苯基]-3,8-二甲基-N-(1-甲基-4-哌啶基)-9H-吡啶并[2,3-B]吲哚-7-甲酰胺
A non-selective inhibitor of Aurora kinases
GC14592 KW 2449
[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮
A multi-kinase inhibitor
GC10479 PHA-680632
Pha 680632
An Aurora kinase inhibitor
GC13837 SNS-314 Mesylate
N-(3-氯苯基)-N'-[5-[2-(噻吩并3,2-D]嘧啶-4-基氨基)乙基]-2-噻唑基]脲甲磺酸盐(1:1)
A pan-Aurora kinase inhibitor
GC17162 MK-5108 (VX-689)
VX-689
A potent inhibitor of Aurora kinases
GC13198 AMG-900 A selective pan-Aurora kinase inhibitor
GC17196 Hesperadin A multi-kinase inhibitor
GC10638 AT9283 A broad spectrum kinase inhibitor
GC15217 Danusertib (PHA-739358)
达鲁舍替,5-Amido-pyrrolopyrazole 9d
A pan-Aurora kinase and Abl inhibitor
GC12612 JNJ-7706621
JNJ7706621, JNJ 7706621
A dual inhibitor of CDKs and Aurora kinases
GC12208 MLN8054
4-[[9-氯-7-(2,6-二氟苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]苯甲酸
An inhibitor of Aurora A kinase
GC14566 CCT137690
甲磺酸阿贝西尼
An inhibitor of Aurora kinases and FLT3
GC11310 CCT129202
2-[4-[6-氯-2-(4-二甲基氨基苯基)-3H-咪唑并[4,5-B]吡啶-7-基]哌嗪-1-基]-N-(噻唑-2-基)乙酰胺,CCT-129202, CCT 129202
An Aurora kinase inhibitor
GC16519 ENMD-2076
6-(4-甲基-1-哌嗪基)-N-(5-甲基-1H-吡唑-3-基)-2-[(1E)-2-苯乙烯基]-4-嘧啶胺
A multi-kinase inhibitor
GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
GC14409 ZM 447439 Selective inhibitor of Aurora B kinase
GC14955 Barasertib (AZD1152-HQPA)
5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺,AZD1152-HQPA,AZD-1152HQPA, AZD1152 HPQA,INH 34
A selective Aurora kinase B inhibitor
GC11549 VX-680 (MK-0457,Tozasertib)
陶扎色替,VX 680; MK-0457
An Aurora kinase inhibitor that regulates mitosis
GC12690 MLN8237 (Alisertib)
阿立塞替,MLN 8237
Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。
GC15084 2-Methoxyestradiol (2-MeOE2)
二甲氧基雌二醇; 2-ME2; NSC-659853
2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。
GC10512 Y-27632 dihydrochloride
y-27632, Y27632, Y-27632 dihydrochloride, Y 27632
Y-27632 dihydrochloride 作为一种选择性 Rho 激酶抑制剂，是一种新型支气管扩张剂。
GN10696 Garcinone C
伽升沃 C
Garcinone C 是一种黄酮衍生物，是一种从 Garcinia oblongifolia Champ 中提取的天然化合物，用作抗炎、收敛和促进肉芽的药物，对某些癌症具有潜在的细胞毒性作用。 Garcinone C 刺激 ATR 和 4E-BP1 的表达水平，同时有效抑制 cyclin B1、cyclin D1、cyclin E2、cdc2、Stat3 和 CDK7 的表达水平。 Garcinone C 以时间和剂量依赖性方式显着抑制人鼻咽癌 (NPC) 细胞系 CNE1、CNE2、HK1 和 HONE1 的细胞活力。
GN10426 Deacetyltaxol
10-去乙酰紫杉醇; 10-Deacetylpaclitaxel
An anticancer taxane
GN10780 Cephalomannine
三尖杉宁碱
A taxane diterpenoid
GN10625 7-Epitaxol
7-表紫杉醇; 7-epi-Paclitaxel
An active metabolite of paclitaxel
GN10299 Vinorelbine
长春瑞宾
An inhibitor of microtubule polymerization
GN10732 Oroxin B
木蝴蝶苷B
Oroxin B (OB) 是从中草药 Oroxylum indicum (L.) Vent 中分离得到的黄酮类化合物。Oroxin B (OB) 具有明显的抑制作用，通过上调 PTEN、下调 PTEN 诱导肝癌细胞早期凋亡而不是晚期凋亡COX-2、VEGF、PI3K 和 p-AKT.Oroxin B (OB) 在恶性淋巴瘤细胞中选择性诱导肿瘤抑制性 ER 应激。
GN10091 Schaftoside
夏佛塔苷
A flavonoid C-glycoside with diverse biological activities