Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC11944 PF 4800567 hydrochloride A selective CK1ε inhibitor
GC16167 K 858 An inhibitor of Eg5
GC16413 TMCB
4,5-二氢-N-(2,3,5,6-四溴-4-甲氧基苯基)-1H-咪唑-2-甲酰胺
A dual inhibitor of CK2 and ERK8
GC16429 (R)-DRF053 dihydrochloride cdk/CK1 inhibitor,potent and ATP-competitive
GC13268 Cyclapolin 9 Cyclapolin 9 是一种有效的、选择性的和 ATP 竞争性的 polo 样激酶 1 (PLK1) 抑制剂，IC50 为 500 nM。 Cyclapolin 9 对其他激酶无活性。
GC13448 NSC 109555 ditosylate An inhibitor of Chk2
GC17150 Ryuvidine
Cdk4 Inhibitor III, Cyclic-dependent Kinase 4 Inhibitor III, SPS812
An inhibitor of SETD8
GC12886 NSC 625987
Cdk4 Inhibitor II
A Cdk4/cyclin D1 complex inhibitor
GC11410 Aminopurvalanol A
NG 97
A selective CDK inhibitor
GC11634 NSC 693868
1H-吡唑并[3,4-B]喹喔啉-3-胺,Cdk1/5 Inhibitor
A selective inhibitor of Cdk1 and Cdk5
GC17631 Combretastatin A4
康普瑞汀; CRC 87-09
A potent inhibitor of tubulin polymerization
GC13440 Cytochalasin D
细胞松弛素D; Zygosporin A; NSC 209835

An inhibitor of actin polymerization
GC16771 TC-S 7005 TC-S 7005 是一种 Polo 样激酶 (Plks) 抑制剂，对 Plk2、Plk3 和 Plk1 的 IC50 分别为 4 nM、24 nM 和 214 nM。
GC17977 PM 102 heparin antagonist
GC14589 KF 38789 KF 38789是一种新型的低分子量P选择素抑制剂，IC₅₀为1.97µM。
GC13100 [Ala92]-p16 (84-103) inhibitor of cyclin-dependent kinase-4 (cdk4)/cyclin D1
GC10244 Ac2-12 Ac2-12 是一种膜联蛋白/脂皮质素 1 (LC1) 模拟肽，可抑制中性粒细胞外渗。
GC15598 Ac2-26 An annexin A1-mimetic peptide
GC12092 TMPyP4 tosylate
TMPYP[=Α,Β,Γ,Δ-四(1-甲基吡啶嗡-4-基)卟吩对甲苯磺酸盐][铜和镁用超高灵敏分光光度试剂][用于以高效液相色谱金属同时测定],TMP 1363
A telomerase inhibitor
GC15671 Latrunculin A
红海海绵素A,LAT-A

一种可逆抑制肌动蛋白聚合的药物
GC17839 Stauprimide
NBenzoyl7oxo Staurosporine
Primes stem cells for differentiation
GC10793 TCS 2312 checkpoint kinase 1 (chk1) inhibitor
GC13649 Arcyriaflavin A A CDK4 and CAMKII inhibitor
GC16727 Flutax 1 荧光紫杉醇衍生物；微管染色
GC10954 Leptomycin B
来普霉素B; CI 940; LMB
Leptomycin B (LMB)是染色体区域维持1 (CRM1)的抑制剂,CRM1是核蛋白输出蛋白之一。
GC14182 Kenpaullone
克莱拉尼,9-Bromopaullone; NSC-664704
A inhibitor of cyclin-dependent kinase and GSK3β
GC12642 THZ1 Hydrochloride A covalent Cdk7 inhibitor
GC17712 AT13148 A multi-AGC kinase inhibitor
GC12515 NMS-1286937
4,5-二氢-1-(2-羟基乙基)-8-[[5-(4-甲基-1-哌嗪基)-2-(三氟甲氧基)苯基]氨基]-1H-吡唑并[4,3-H]喹唑啉-3-甲酰胺,NMS-1286937; NMS-P937
An inhibitor of Plk1
GC14162 ML167
5-[4-[[(5-甲基-2-呋喃基)甲基]氨基]-6-喹唑啉基]-2-呋喃甲醇,CID44968231; NCGC00188654
A selective Clk4 inhibitor
GC10083 MPI-0479605 A potent inhibitor of MPS1
GC15462 ISRIB (trans-isomer)
ISRIB(TRANS-ISOMER)抑制剂
ISRIB (trans-isomer)是一种选择性抑制整合应激反应（ISR）通路的小分子化合物。ISRIB (trans-isomer)是PERK的一种高度选择性抑制剂，IC₅₀为5nM。
GC17388 K-Ras(G12C) inhibitor 6
K-RAS(G12C)抑制剂6
K-Ras(G12C) inhibitor 6 是一种不可逆的 K-Ras(G12C) 变构抑制剂。
GC13484 Griseofulvin
灰黄霉素
A fungal metabolite with antifungal and anticancer activities
GC14800 ML 141
CID-2950007
An allosteric Cdc42 inhibitor
GC14735 Poloxime Poloxime 是 poloxin 的水解产物，是一种非 ATP 竞争性 Plk1 抑制剂，具有中等的 Plk1 抑制活性。
GC13869 Fasudil
法舒地尔; HA-1077; AT877
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC10840 THZ1 A covalent Cdk7 inhibitor
GC17936 GSK269962A
N-[3-[[2-(4-氨基呋咱-3-基)-1-乙基-1H-咪唑并[4,5-C]吡啶-6-基]氧]苯基]-4-[[2-(4-吗啉基)乙基]氧]苯甲酰胺,GSK 269962
A ROCK1 and ROCK2 inhibitor
GC14354 Eribulin
艾日布林; B1939; E7389; ER-086526
Eribulin (E7389) 是一种微管靶向剂，用于研究转移性乳腺癌。艾日布林通过结合微管蛋白和微管来抑制癌细胞的增殖。
GC12483 Eribulin mesylate
甲磺酸艾日布林; B1939 mesylate; E7389 mesylate; ER-086526 mesylate
Eribulin mesylate (E7389 mesylate) 是一种微管靶向剂，用于研究转移性乳腺癌。甲磺酸艾日布林通过结合微管蛋白和微管来抑制癌细胞的增殖。
GC13210 Flubendazole
氟苯咪唑
An anthelmintic
GC13815 Vinflunine Tartrate
长春氟宁酒石酸盐

Etanercept is an inhibitor of the inflammatory factor TNF-α and is mainly used for the clinical treatment of rheumatoid arthritis .
GC10537 Triclabendazole
三氯苯达唑; CGA89317
A benzimidazole anthelmintic
GC11383 CYT997 (Lexibulin)
CYT-997
An inhibitor of microtubule polymerization
GC15663 LY2606368
5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368
LY2606368 是一种 ATP 竞争性 CHK1 抑制剂，目前处于临床阶段，Ki 为 0.9 nM，IC50 <1 nM。
GC12142 KPT-276 An inhibitor of XPO1/CRM1
GC12467 KPT-330
塞利尼索
KPT-330（Selinexor）是一种具有口服活性的选择性核输出抑制剂（SINE）化合物，抑制核输出蛋白XPO1（又名CRM1）。
GC12308 Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
CA 4DP; CA 4P; Combretastatin A4 disodium phosphate
A potent inhibitor of tubulin polymerization
GC15377 LEE011 succinate
瑞博西尼琥珀酸盐; LEE011 succinate
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor