Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC15922 LEE011 hydrochloride
瑞博西尼盐酸盐; LEE011 hydrochloride
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
GC16225 IPA-3 An allosteric inhibitor of PAK1
GC11785 CDK4 inhibitor
瑞博西尼
An antiproliferative cyclin D1/Cdk4 inhibitor
GC14517 KPT-185 An inhibitor of XPO1/CRM1
GC16273 Dolastatin 10
DLS 10; NSC 376128
Dolastatin 10 (DLS 10) 是一种有效的抗有丝分裂肽，可抑制微管蛋白聚合。
GC12261 FRAX597 A PAK1, PAK2, and PAK3 inhibitor
GC11765 Cabazitaxel
卡巴他赛,XRP6258; RPR-116258A; taxoid XRP6258
A semisynthetic taxane
GC13328 XL413 hydrochloride
BMS-863233 hydrochloride
A potent inhibitor of Cdc7
GC18117 XL413 A potent inhibitor of Cdc7
GC16607 Mesalamine
5-氨基水杨酸; Mesalamine; 5-ASA; Mesalazine
An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine
GC10235 Plinabulin (NPI-2358)
普那布林; NPI-2358
A tubulin depolymerizing agent
GC15745 Mps1-IN-2
9-环戊基-2-[[2-乙氧基-4-(4-羟基哌啶-1-基)苯基]氨基]-5-甲基-8,9-二氢-5H-嘧啶并[4,5-B][1,4]二氮杂卓-6(7H)-酮
An inhibitor of Mps1
GC11648 BML-277
Chk2 Inhibitor II
A selective DNA damage control kinase inhibitor
GC10722 SR-3677
N-[2-[2-(二甲基氨基)乙氧基]-4-(1H-吡唑-4-基)苯基]-2,3-二氢-1,4-苯并二恶烷-2-甲酰胺
A ROCK1 and ROCK2 inhibitor
GC17801 PYZD-4409 PYZD-4409 是泛素激活酶 UBA1 的特异性抑制剂，IC50 为 20 μM（无细胞酶测定）。 PYZD-4409 在恶性细胞中诱导细胞死亡并优先抑制原发性急性髓细胞白血病细胞的克隆形成。
GC14600 SB743921 An Eg5 inhibitor
GC12415 Rigosertib
瑞格色替; ON-01910
Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3 激酶/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。
GC13580 Rigosertib sodium
瑞格色替钠,ON-01910 sodium
Rigosertib sodium (ON-01910 sodium) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3K/Akt 通路诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期 G2/M 停滞。 Rigosertib sodium 是一种选择性和非 ATP 竞争性的 PLK1 抑制剂，IC50 为 9 nM。
GC14288 KX2-391
5-[4-[2-(4-吗啉基)乙氧基]苯基]-N-(苯基甲基)-2-吡啶乙酰胺,KX2-391; KX-01
A Src kinase inhibitor
GC15712 Y-27632 A ROCK inhibitor
GC13423 Y-39983 dihydrochloride ROCK family inhibitor
GC14234 PF-477736
PF 00477736
A selective inhibitor of checkpoint kinase 1
GC17994 Kif15-IN-2
(ALPHAS)-1,4-二氢-ALPHA-异丙基-N-[4-甲基-5-(5-甲基-1,3,4-恶二唑-2-基)-2-噻唑基]-2,4-二氧代-3(2H)-喹唑啉乙酰胺
Kif15-IN-2 是有丝分裂驱动蛋白 Kif15 的抑制剂，用于细胞增殖性疾病的研究。
GC16603 Kif15-IN-1
2-[[(2S)-2-(1,4-二氢-2,4-二氧代-3(2H)-喹唑啉基)-3-甲基-1-氧代丁基]氨基]-4-甲基-5-噻唑羧酸乙酯
Kif15-IN-1 是有丝分裂驱动蛋白家族成员 15 (Kif15) 的抑制剂，用于细胞增殖性疾病的研究。
GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
GC10034 MMAF
一甲基澳瑞他汀F,Monomethylauristatin F
An auristatin with anticancer activity
GC10030 EHop-016 A Rac1 and Rac3 inhibitor
GC11068 GSK2656157 A PERK inhibitor
GC15337 VE-822 ATR抑制剂
GC11252 CW069 An inhibitor of KIFC/HSET
GC15894 CK-636
CK-0944636
An inhibitor of Arp2/3 complex action
GC10442 MK-8745 An Aurora A kinase inhibitor
GC13903 Ro3280 A selective Plk1 inhibitor
GC10163 MLN0905
2-[[5-[3-(二甲基氨基)丙基]-2-甲基-3-吡啶基]氨基]-5,7-二氢-9-(三氟甲基)-6H-嘧啶并[5,4-D][1]苯并氮杂卓-6-硫酮,PLK1 Inhibitor
A Plk1 inhibitor
GC16000 WHI-P180
3-[(6,7-二甲氧基-4-喹唑啉基)氨基]苯酚,Janex 3
A multi-kinase inhibitor
GC17400 R547
[4-氨基-2-[(1-甲磺酰基哌啶-4-基)氨基]嘧啶-5-基](2,3-二氟-6-甲氧基苯基)甲酮
A selective Cdk inhibitor
GC10842 LEE011
瑞博西尼; LEE011
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor
GC16425 Flavopiridol hydrochloride
(-)-2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]-4H-1-苯并吡喃-4-酮盐酸盐,Alvocidib Hydrochloride; L86-8275 Hydrochloride; HMR-1275 Hydrochloride
An inhibitor of cyclin-dependent kinases
GC11835 Deferasirox
地拉罗司; ICL 670
Deferasirox是一种具口服活性的铁螯合剂，用于治疗铁过载疾病。
GC15741 LY2603618
LY2603618; IC-83
A Chk1 inhibitor
GC10196 ETP-46464
ATM Inhibitor III, ATR Inhibitor III
An ATR inhibitor
GC16489 CP-466722 An ATM kinase inhibitor
GC14526 CGK733
ATM/ATR Kinase Inhibitor
An anticancer compound
GC16268 Purvalanol B
(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇,NG 95; NG95; NG-95
A CDK inhibitor
GC11224 BI6727(Volasertib)
伏拉塞替; BI 6727
A polo-like kinase inhibitor
GC14807 Fingolimod (FTY720) HCl
盐酸芬戈莫德; FTY720
芬戈莫德(FTY720)是一种免疫抑制剂,通常用于治疗多发性硬化症,也有抗癌作用,可以作为HDACi(组蛋白脱乙酰酶抑制剂)。
GC17648 Dinaciclib(SCH727965)
(2S)-1-[3-乙基-7-[[(1-氧代-3-吡啶基)甲基]氨基]吡唑并[1,5-A]嘧啶-5-基]-2-哌啶乙醇,SCH 727965
A CDK inhibitor
GC15739 CHIR-124
4-[((3S)-1-氮杂双环[2,2,2]辛-3-基)氨基]-3-(1H-苯并咪唑-2-基)-6-氯喹啉-2(1H)-酮
A selective Chk1 inhibitor
GC12865 BMS265246 A cell-permeable inhibitor of Cdk1 and Cdk2
GC12338 Wortmannin
渥曼青霉素; SL-2052; KY-12420
渥曼青霉素是一种高效的 PI3 激酶特异性直接抑制剂，最初源自真菌 (1,2)。