Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC15173 PD 0332991 (Palbociclib)
帕布昔利布（palbociclib）,PD0332991;PD-0332991;PD 0332991
PD 0332991 (Palbociclib) (PD 0332991) 是一种具有口服活性的选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。 PD 0332991 (Palbociclib) 具有有效的抗增殖活性，可诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。
GC10581 ISRIB ISRIB是PERK信号抑制剂
GC18051 CCT251545 analogue, Compound 51
Potent, Selective, orally bioavailable CDK 8/19 Inhibitor
GC16420 THZ531 An inhibitor of Cdk12 and Cdk13
GC15773 Myoseverin
肌基质蛋白
A microtubule-binding trisubstituted purine
GC14929 Monastrol
(±)-Monastrol
Reversible inhibitor of the motor protein Eg5
GC15940 PalMitoyl Tripeptide-1
棕榈酰三肽-1
A form of GHK containing palmitic acid
GC14230 K03861
AUZ454或者K03861,K03861
K03861 (K03861) 是一种 II 型 CDK2 抑制剂，Kd 为 8.2 nM。 K03861 (K03861) 通过与活化细胞周期蛋白的结合竞争抑制 CDK2 活性。
GC16472 ARQ 621 An Eg5 inhibitor
GC10557 Dolastatin 10 trifluoroacetate Antitumor agent
GC17828 BI-847325 A selective dual MEK/Aurora kinase inhibitor
GC16941 AZD6738
AZD6738
An ATR kinase inhibitor
GC17208 Dyngo-4a
Dyngo-4a
An inhibitor of dynamin
GC16545 GX-674 GX-674 是一种有效的、状态依赖性、异构体选择性电压门控钠通道 1.7 (Nav1.7) 拮抗剂，在 -40 mV 时的 IC50 为 0.1 nM。
GC13511 THZ2 A Cdk7 inhibitor
GC14615 KPT-9274 Orally acitve allosteric inhibitor of PAK4
GC12826 AZD-5597
[4-[[5-氟-4-[2-甲基-1-(1-甲基乙基)-1H-咪唑-5-基]-2-嘧啶基]氨基]苯基][(3S)-3-(甲氨基)-1-吡咯烷]甲酮

Potent CDK inhibitor
GC11905 Cevipabulin
5-氯-6-[2,6-二氟-4-[3-(甲基氨基)丙氧基]苯基]-N-((1S)-2,2,2-三氟-1-甲基乙基)-[1,2,4]三唑并[1,5-A]嘧啶-7-胺,TTI-237
An activator of microtubule polymerization
GC12752 RI-2 A RAD51 inhibitor
GC14772 CCT244747
3-[(1R)-2-(二甲基氨基)-1-甲基乙氧基]-5-[[4-甲氧基-5-(1-甲基-1H-吡唑-4-基)-2-吡啶基]氨基]-2-吡嗪甲腈
A potent Chk1 inhibitor
GC16827 ELR510444 An inhibitor of tubulin polymerization
GC12402 LX7101 HCL A LIMK and ROCK inhibitor
GC10773 TAK960 A selective inhibitor of polo-like kinase 1
GC14644 SBE 13 HCl A potent Plk1 inhibitor
GC14857 LFM-A13 A BTK inhibitor
GC14707 Purvalanol A
NG-60
A selective inhibitor of cyclin-dependent kinases
GC13759 SAR407899 A ROCK1 and ROCK2 inhibitor
GC16289 SAR407899 hydrochloride
6-(哌啶-4-氧基)异喹啉-1(2H)-酮盐酸盐
A ROCK1 and ROCK2 inhibitor
GC11292 Mps1-IN-1
Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1
A selective Mps1 kinase inhibitor
GC12795 CCG-1423 An inhibitor of Rho-mediated cell signalling
GC17559 TAI-1 TAI-1 是一种口服活性抗癌剂，是一种高效的一流 Hec1 抑制剂，在 K562 细胞中的 GI50 为 13.48 nM。
GC12348 Ro 3306
2-[[(噻吩-2-基)甲基]氨基]-5-[1-(喹啉-6-基)甲-(Z)-亚基]噻唑-4-酮
Ro 3306是一种ATP竞争性抑制剂，主要靶向CDK1/cyclin B1（K_i值为35nmol/L）和CDK1/cyclin A复合物（K_i值为110nmol/L）。
GC16475 Afuresertib
GSK2110183
A pan-Akt inhibitor
GC12817 K-115 hydrochloride dihydrate
(2S)-1-[(4-氟-5-异喹啉基)磺酰基]六氢-2-甲基-1H-1,4-二氮杂卓单盐酸盐二水合物,K-115
K-115 hydrochloride dihydrate (K-115) 是 ROCK 的特异性抑制剂，对 ROCK2 和 ROCK1 的 IC50 分别为 19 和 51 nM。
GC15777 Verdinexor (KPT-335)
KPT-335
An inhibitor of XPO1
GC15478 6H05
6H05(6H零5)
An allosteric inhibitor of oncogenic K-Ras(G12C)
GC18021 Ac-YVAD-CHO
乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨醛,L-709049
An inhibitor of caspase-1
GC10019 SF1670 SF1670是一种有效的特异性PTEN（第10号染色体上缺失的磷酸酶和张力蛋白同源物）抑制剂。
GC15285 MPC 6827 hydrochloride
N-(4-甲氧基苯基)-N,2-二甲基-4-喹唑啉胺盐酸盐,MPC-6827 hydrochloride
An inhibitor of tubulin polymerization with anticancer activity
GC16741 UNC0379 A selective SET8 inhibitor
GC11971 LY2857785 A Cdk9 inhibitor
GC10334 INH6
N-[4-(2,4,6-三甲基苯基)-2-噻唑基]苯甲酰胺
A Hec1/Nek2 inhibitor
GC17067 LDC000067
(3-(6-(2-甲氧基苯基)嘧啶-4-基氨基)苯基)甲烷磺酰胺,LDC067
A Cdk9 inhibitor
GC15076 CK 869
CK-0157869
An inhibitor of the Arp2/3 complex
GC11754 AS 1892802 A ROCK1 and ROCK2 inhibitor
GC15170 SB 772077B dihydrochloride A ROCK1 and ROCK2 inhibitor
GC14060 CK 666 An Arp2/3 inhibitor
GC13491 Mirin
(5Z)-2-氨基-5-[(4-羟基苯基)亚甲基]-4(5H)-噻唑酮
Mirin是一种Mre11-Rad50-Nbs1（MRN）复合物抑制剂（IC₅₀=12μM），能够抑制Mre11相关的外切酶活性，Mirin可抑制MRN依赖的ATM的激活。通常用于与DNA修复机制相关的癌症的研究。
GC12788 Paprotrain
(ALPHAZ)-ALPHA-(3-吡啶基亚甲基)-1H-吲哚-3-乙腈
A MKLP-2 inhibitor
GC13727 TC Mps1 12 TC Mps1 12 是一种有效的选择性单极纺锤体 1 (Mps1) 抑制剂，IC50 为 6.4 nM。