Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC45750 Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate)
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2
An actin-sequestering peptide
GC45724 Corticosterone-d8
皮质酮 d8
An internal standard for the quantification of corticosterone
GC45722 Decanoic Acid-d3
癸酸 d3
An internal standard for the quantification of decanoic acid
GC45721 Stiripentol-d9
斯利潘托 d9
An internal standard for the quantification of stiripentol
GC45698 1,2,3-Triheptanoyl-rac-glycerol
三庚酸甘油酯
A triacylglycerol
GC45692 Cholesteryl Palmitate-d9
16:0-d9 Cholesterol ester, Cholesterol Palmitate-d9, 16:0-d9(CE), CE(16:0-d9)
A neuropeptide with diverse biological activities
GC45684 Selank (acetate) A synthetic derivative of tuftsin
GC45676 MLS-1547 An agonist of dopamine D₂ receptors
GC45661 C16 Sphingomyelin-d9 (d18:1/16:0-d9)
Palmitoyl Sphingomyelin-d9
具有多种生物活性的神经肽
GC38698 1-Naphthyl acetate
乙酸-1-萘酯
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity.
GC38693 Choline bitartrate
酒石酸氢胆碱
Choline bitartrate (2-hydroxyethyl(trimethyl)azanium, 2,3,4-trihydroxy-4-oxobutanoate) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcholine, a chemical that facilitates communication between the nerves and muscles.
GC38678 Ethyl Caffeate
咖啡酸乙酯
Ethyl caffeate, a naturally occurring compound found in Bidens pilosa, suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2 and PGE2 in vitro.
GC38677 (-)-α-Pinene
β-蒎烯; (-)-β-Pinene
(-)-α-Pinene 是一种单萜类化合物，通过在 BZD 结合位点作为部分调节剂与 GABAA-苯二氮卓 (BZD) 受体直接结合，显示出增强睡眠的特性。
GC38658 Oxotremorine M iodide
Oxotremorine M iodide 是一种有效的，选择性毒蕈碱型乙酰胆碱受体 (mAChR) 激动剂。Oxotremorine M iodide 通过毒蕈碱受体依赖和独立机制增强 NMDA 受体。
GC38657 Meclofenamate sodium
甲氯灭酸钠,Meclofenamate sodium
A competitive inhibitor of COX-1 and -2
GC38628 Licochalcone B
甘草查尔酮 B
Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
GC38625 Dehydronuciferine
去氢荷叶碱
Dehydronuciferine 从 Nelumbo nucifera Gaertn 的叶子中分离，是一种乙酰胆碱酯酶 (AChE) 抑制剂，其 IC50 为 25 μg/mL。
GC38616 Hamaudol
亥茅酚
Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效的镇痛和抗炎作用。
GC38583 PXS-5153A monohydrochloride PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3 (LOXL2/LOXL3) 的双抑制剂，对几乎所有哺乳动物LOXL2的IC50 均< 40 nM，对人类LOXL3 的IC50 为63 nM。PXS-5153A monohydrochloride 可减少交联，改善纤维化。
GC38558 PF-03654746 Tosylate
反式-N-乙基-3-氟-3-[3-氟-4-(1-吡咯烷基甲基)苯基]-环丁烷甲酰胺4-甲基苯磺酸盐
PF-03654746 Tosylate (PF-03654746) 是一种有效的选择性组胺 H3 receptor 拮抗剂，具有脑渗透性。PF-03654746 Tosylate (PF-03654746) 可减少过敏原引起的鼻炎反应。PF-03654746 Tosylate (PF-03654746) 用于治疗人类认知障碍，改善阿尔茨海默病人 (AD) 的认知。
GC38529 Geissoschizine methyl ether
缝籽木嗪甲醚
Geissoschizine methyl ether，一种 Uncaria hook 发现的生物碱类化合物，也是具有精神药物作用的 Yokukansan 的主要活性成分。Geissoschizine methyl ether 是有效的 5-HT1A 受体的激动剂。
GC38509 Masupirdine mesylate
SUVN-502 mesylate
Masupirdine mesylate (SUVN-502 mesylate) 是一种有效的，选择性的，具有口服生物可利用且可穿透脑屏障的 5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine mesylate (SUVN-502 mesylate) 对 5-HT2A 受体和其他 100个靶点显示高选择性，有治疗阿尔茨海默病的潜力。
GC38489 (1α,1'S,4β)-Lanabecestat
(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) 是一种 BACE1 抑制剂，IC50 分别为 2.2 nM (TR-FRET 测定) 和 0.28 nM (sAPPp 释放测定)，详细信息请参考专利文献 WO2012087237A1 中的化合物 20a。
GC38450 LML134 LML134 (化合物 18b) 是一种具有口服活性，高选择性 H3R (组胺 3 受体) 反向激动剂，对 hH3R 的 cAMP 和 bdg 的 Kis 分别为 0.3 nM 和 12 nM。LML134 快速穿透大脑，导致高 H3R 占有率，并以快速的动力学特征使其目标脱离。LML134 用于治疗过度睡眠障碍。
GC38433 Jatrorrhizine
药根碱
An alkaloid with diverse biological activities
GC38431 Dehydroevodiamine
脱氢吴茱萸碱
An alkaloid with diverse biological activities
GC38413 Harmine hydrochloride
哈尔碱盐酸盐(水合),Telepathine hydrochloride
A unique regulator of PPARγ expression
GC38411 Picfeltarraenin IA
苦玄参苷 IA
Picfeltarraenin IA is an AChE inhibitior, and an potential PI3K and EGFR inhibitor. It also acts as an inhibitor on both the classical and alternative pathways of the complement system.
GC38405 Odapipam
奥达匹泮,NNC 756
Odapipam (NNC 756) 是一种选择性，高亲和力的苯并氮杂卓多巴胺 D1 受体拮抗剂，Kd 为 0.18 nM。Odapipam 还是一种出色的正电子发射断层扫描 (PET) 放射性示踪剂。
GC38387 CP-409092 hydrochloride CP-409092 hydrochloride 是 GABAA 受体的部分激动剂，具有抗焦虑活性。
GC38231 Pericyazine
氰噻嗪,Propericiazine; RP 8909
A typical antipsychotic
GC38228 D-Tetrahydropalmatine
右旋四氢巴马汀
A tetrahydroberberine alkaloid
GC38227 Gamma-Mangostin
γ-倒捻子素,γ-Mangostin
A xanthone with diverse biological activities
GC38224 Crocin II
西红花苷II
Crocin II (Crocin B, Crocetin gentiobiosylglucosyl ester, Tricrocin), a carotenoid chemical compound that is found in the flowers crocus and gardenia, is an antioxidant and neural protective agent.
GC38198 Revaprazan hydrochloride
盐酸瑞伐拉赞
Revaprazan Hydrochloride (YH1885) is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. Revaprazan Hydrochloride reversibly inhibits H(+)/K(+)-ATPase via binding to the K+-binding site of the pump.
GC38184 Dehydrodiisoeugenol
脱氢二异丁香酚
Dehydrodiisoeugenol, a naturally occurring lignan from Aristolochia taliscana (Aristolochiaceae), acts as a potent anti-inflammatory agent and shows various pharmacological activities, including anti-lipid peroxidation, anti-bacteial function, and hepatic drug metabolism enzyme inhibition.
GC38151 Roburic acid
栎樱酸
Roburic acid 是秦艽中的四环三萜类化合物，作为一种 COX 的抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 5 和 9 μM。
GC38111 Rac-VU 6008667 Rac-VU 6008667 是毒蕈碱乙酰胆碱受体亚型 5 (M5 NAM) 的选择性负变构调节剂，对于人和大鼠的 IC50 值分别为 1.2 μM 和 1.6 μM。Rac-VU 6008667 具有高 CNS 渗透性。
GC38108 2-Methyl-5-HT
2-甲基-5-羟基色氨酸盐酸,2-Methyl-5-hydroxytryptamine; 2-Methylserotonin; 2-Me-5-HT
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) 是一种有效的选择性 5-HT3 受体激动剂。2-Methyl-5-HT 显示出抗抑郁样作用。
GC38066 Mavacoxib
吗伐考昔
Mavacoxib (Trocoxil) is a selective, long-acting cyclooxygenase-2 (COX-2) inhibitor. Mavacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID).
GC38026 Violanthin
紫罗兰素
Violanthin 是从胡椒 Piper bavinum 中分离出来，具有抗氧化和抗菌活性。Violanthin 抑制乙酰胆碱酯酶 (AChE)，IC50 值为 79.80 μM。
GC38013 [Sar9,Met(O2)11]-Substance P TFA [Sar9,Met(O2)11]-Substance P TFA 是一种选择性的速激肽 NK1 受体激动剂。
GC18262 Acetamiprid
啶虫脒
A neonicotinoid insecticide
GA22579 H-Ile-Trp-OH
H-Ile-Trp-OH; IW-2143
H-Ile-Trp-OH (H-Ile-Trp-OH) 是一种具有口服活性的 α7 nAChR 负性改变调节剂 (NAM)，没有明显的副作用。
GA21898 Gastrin I (rat)
胃泌素,鼠,Rat Gastrin-17
胃泌素I（大鼠）（Rat Gastrin-17）是一种肽类激素，能有效刺激胃酸分泌。
GA20847 Biotinyl-Substance P Biotinyl-Substance P 是生物素标记的 Substance P。
GA20736 Amyloid β-Protein (1-43)
淀粉Β-蛋白(1-43)
淀粉样蛋白 β-Protein (1-43) 比久负盛名的 Aβ1-42 更容易聚集并具有更高的毒性。
GA20733 Amyloid β-Protein (1-42)
大豆肽
与内盐相比，Aβ42 的盐酸盐在 pH 7.4 时更容易聚集。
GC45592 Urotensin I (white sucker) (trifluoroacetate salt) A peptide
GC45591 Urocortin III (mouse) (trifluoroacetate salt) A neuropeptide hormone