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Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) Sale

(Synonyms: Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2) 目录号 : GC45750

An actin-sequestering peptide

Thymosin β4 (human, mouse, rat, porcine, bovine) (acetate) Chemical Structure

规格 价格 库存 购买数量
500μg
¥2,552.00
现货
1mg
¥4,078.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Thymosin β4 is an actin-sequestering peptide that has wound healing and anti-inflammatory activities.1,2,3 It regulates cytoskeletal rearrangement by binding to actin (Kds = 0.7 and 2.1 μM for human platelets and rabbit muscle, respectively) and inhibiting the polymerization of actin monomers.1 Thymosin β4 increases in vitro migration of human umbilical vein endothelial cells (HUVECs), keratinocytes, and coronary artery endothelial cells, but not fibroblasts, actin smooth muscle cells, neutrophils, monocytes, or HT-1080 fibrosarcoma cells, when used at concentrations ranging from 0.001 to 1 μg/ml.2,4 It increases gap closure and reduces wound width in a rat full-thickness cutaneous wound model when administered at a dose of 60 μg.2 Thymosin β4 (1 μg/ml) inhibits TNF-α-induced NF-•B phosphorylation and nuclear translocation in immortalized human corneal epithelial cells and decreases the expression of chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, matrix metalloproteinase-9 (MMP-9), and MMP-2 in the cornea in a mouse model of sodium hydroxide-induced corneal injury when administered at a dose of 5 μg.3

|1. Weber, A., Nachmias, V.T., Pennise, C.R., et al. Interaction of thymosin β4 with muscle and platelet actin: Implications for actin sequestration in resting platelets. Biochemistry 31(27), 6179-6185 (1992).|2. Malinda, K.M., Sidhu, G.S., Mani, H., et al. Thymosin β4 accelerates wound healing. J. Invest. Dermatol. 113(3), 364-368 (1999).|3. Sosne, G., Qiu, P., Christopherson, P.L., et al. Thymosin beta 4 suppression of corneal NFκB: A potential anti-inflammatory pathway. Exp. Eye Res. 84(4), 663-669 (2007).|4. Malinda, K.M., Goldstein, A.L., and Kleinman, H.K. Thymosin β4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J. 11(6), 474-481 (1997).

Chemical Properties

Cas No. N/A SDF
别名 Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2
Canonical SMILES N/A
分子式 C212H350N56O78S.XCF3CO2H 分子量 4963.4
溶解度 PBS (pH 7.2): 10mg/mL 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.2015 mL 1.0074 mL 2.0147 mL
5 mM 0.0403 mL 0.2015 mL 0.4029 mL
10 mM 0.0201 mL 0.1007 mL 0.2015 mL
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