Cell Cycle/Checkpoint(细胞周期/检查点)

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for Cell Cycle/Checkpoint

Cat.No. 产品名称 Information
GC46907 Bazedoxifene-d4
1-[[4-[2-(六氢-1H-氮杂卓-1-基)乙氧基-1,1,2,2-D4]苯基]甲基]-2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇,TSE-424-d4
An internal standard for the quantification of bazedoxifene
GC46895 Aurintricarboxylic Acid (ammonium salt)
铝试剂
A protein synthesis inhibitor with diverse biological activities
GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid
GC46882 Artemisinin-d3
Qinghaosu-d3; NSC 369397-d3
An internal standard for the quantification of artemisinin
GC46878 Aranciamycin
阿雷西霉素
A fungal metabolite with diverse biological activities
GC46867 Apremilast-d5
阿普斯特-D5,CC-10004-d5
An internal standard for the quantification of apremilast
GC46841 Amiloride (hydrochloride) (hydrate)
MK-870
具有多种生物活性的神经肽
GC46825 Alachlor
甲草胺
An herbicide
GC46814 Aflatoxin M1-13C17
AFM1-13C17
A neuropeptide with diverse biological activities
GC46811 Aflatoxin B2-13C17
黄曲霉毒素B2-(全碳-13)
An internal standard for the quantification of aflatoxin B₂
GC46810 Aflatoxin B1-13C17
黄曲霉毒素B1-(全碳-13)
An internal standard for the quantification of aflatoxin B₁
GC46796 Ac-WEHD-AFC (trifluoroacetate salt)
N-Acetyl-Trp-Glu-His-Asp-7-amino-4-Trifluoromethylcoumarin, Caspase1 Substrate (Fluorogenic), Caspase5 Substrate (Fluorogenic)
A neuropeptide with diverse biological activities
GC46791 Ac-LEHD-pNA (trifluoroacetate salt)
Ac-Leu-Glu-His-Asp-pNA, Caspase-9 Chromogenic Substrate I
A neuropeptide with diverse biological activities
GC46790 Acibenzolar-S-methyl
S-甲基苯并[1,2,3]噻二唑-7-硫代羧酸酯,BTH
A fungicide inducer of systemic acquired resistance
GC46786 Acetyl Hexapeptide-3 (acetate)
Ac-EEMQRR-NH2, Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2, Acetyl Hexapeptide-8
A synthetic hexapeptide
GC46733 7,12-Dimethylbenz[a]anthracene
9,10-二甲基-1,2-苯并蒽；DMBA
7,12-Dimethylbenz[a]anthracene是一种免疫抑制剂，也是一种强效的器官特异性致癌物。
GC46721 6-Chloro-2-fluoropurine
2-氟-6-氯嘌呤
A heterocyclic building block
GC46687 5'-Deoxy-5'-methylthioadenosine-d3
5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3
An internal standard for the quantification of 5’-deoxy-5’-methylthioadenosine
GC46681 5-Bromouridine
5-溴尿苷
A brominated uridine analog
GC46635 4-deoxy Nivalenol-13C15
全13C标记的脱氧雪腐镰刀菌烯醇
An internal standard for the quantification of 4-deoxy nivalenol
GC46606 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
4-氨基苯硼酸频哪醇酯
A heterocyclic building block
GC46582 3-Acetyldeoxy Nivalenol-13C17
3-乙酰基呕吐毒素-13C标记
An internal standard for the quantification of 3-acetyldeoxy nivalenol
GC46446 15-deoxy-δ12,14-Prostaglandin J2-biotin
15deoxyΔ12,14PGJ2biotin
A neuropeptide with diverse biological activities
GC46434 13C15-Nivalenol An internal standard for the quantification of nivalenol
GC46385 1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-Mannopyranose
1,3,4,6-四-O-乙酰基-2-叠氮基-2-脱氧-Α-D-吡喃甘露糖
A ManNAc analog and building block
GC46379 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)
1,2-二-(9Z-十八碳烯酰基)-sn-甘油-3-磷酰-L-丝氨酸钠盐
A phospholipid
GC46351 (S)-CR8 An inhibitor of cyclin-dependent kinases
GC46347 (S)-(+)-Methoprene
S-(+)-烯虫酯,(+)-Methoprene; (7S)-Methoprene
An insect growth regulator and Met agonist
GC46335 (E)-Fenpyroximate
唑螨酯
A phenoxypyrazole acaricide
GC46308 (±)-Sitagliptin-d4 (hydrochloride) A neuropeptide with diverse biological activities
GC61314 Taltobulin hydrochloride
HTI-286 hydrochloride; SPA-110 hydrochloride
Taltobulinhydrochloride(HTI-286hydrochloride)是一种合成的三肽半胱氨酸类似物，Taltobulin是一种有效的抗微管剂(antimicrotubule)，可在体内外规避P-糖蛋白介导的耐药性。Taltobulinhydrochloride抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡(apoptosis)。
GC61286 SP-8356 SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
GC61072 MK-28 MK-28是有效、选择性的PERK激动剂。MK-28在小鼠中表现出良好的药代动力学特征，且能透过血脑屏障。
GC61043 Mesalamine impurity P
美沙拉嗪EP杂质P
MesalamineimpurityP是Mesalamine的杂质。5-Aminosalicylicacid(Mesalamine)是一种特异性的 PPARγ 激动剂，还抑制p21-激活激酶1(PAK1)和 NF-κB。
GC61014 Lusianthridin
4,7-二羟基-2-甲氧基-9,10-二氢菲
Lusianthridin是来自Dendrobiumvenustum的天然化合物，具有抗迁移作用。Lusianthridin通过抑制Src-STAT3信号，促进c-Myc的降解。
GC60891 GW406108X
GW108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
GC60871 Gemigliptin tartrate
吉格列汀酒石酸盐,LC15-0444 tartrate
A DPP-4 inhibitor
GC60688 Cereblon modulator 1
CC-90009
A modulator of cereblon
GC60628 BD750 BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.
GC60621 Batabulin sodium
T138067 sodium
An inhibitor of tubulin polymerization
GC60620 Batabulin
巴他布林; T138067
An inhibitor of tubulin polymerization
GC60376 UC2288 UC2288 is a novel, cell-permeable, and orally active p21 attenuator, decreases p21 mRNA expression independently of p53, and attenuates p21 protein levels with minimal effect on p21 protein stability.
GC60311 PTUPB PTUPB是一种新型的COX-2和sEH双抑制剂，IC₅₀ 值分别为 1.26 nM 和 0.9μM。
GC60294 Poloppin Poloppin是一种有效的细胞渗透抑制剂，可抑制有丝分裂的polo样激酶(PLK)IC50=26.9μM)，并可通过Polo-box结构域(PBD)阻止蛋白之间的相互作用(Kd=29.5μM)。Poloppin选择性地杀死表达突变KRAS的细胞，增强有丝分裂中的死亡。Poloppin可用作KRAS突变型癌症的研究，可作为单一试剂，或与c-MET抑制剂联合使用。
GC60259 MYCMI-6
NSC354961
MYCMI-6 (NSC354961) 是一种有效的选择性内源性 MYC:MAX 蛋白相互作用抑制剂。 MYCMI-6 阻断 MYC 驱动的转录。MYCMI-6 选择性结合 MYC bHLHZip 域，Kd 值为 1.6 μM。MYCMI-6 以 MYC 依赖性的方式抑制肿瘤细胞的生长 (IC50<0.5 μM)。MYCMI-6 对正常人细胞无细胞毒性。MYCMI-6 诱导细胞凋亡 (apoptosis)。
GC60143 DM3
Maytansinoid DM3
DM3 (Maytansinoid DM3) 是一种带有二硫键或硫醇基的美登素类似物，是一种 tubulin 的抑制剂，还是一种抗体-药物偶联物 (ADCs) 的细胞毒性部分。
GC60120 Danicamtiv
MYK-491
A cardiac-specific myosin activator
GC39810 CID44216842
Cdc42-IN-1
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
GC39798 Scoulerine
金黄紫堇碱,(-)-Scoulerine; Discretamine
A benzylisoquinoline alkaloid with diverse biological activities
GC39558 Tubulin inhibitor 6
Improved Heterocyclic Activator of PP2A 1, Tubulin Inhibitor 6
An inhibitor of tubulin polymerization and a PP2A activator