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Artemisinin-d3 Sale

(Synonyms: Qinghaosu-d3; NSC 369397-d3) 目录号 : GC46882

An internal standard for the quantification of artemisinin

Artemisinin-d3 Chemical Structure

Cas No.:176652-07-6

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1 mg
¥6,835.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Artemisinin-d3 is intended for use as an internal standard for the quantification of artemisinin . Artemisinin is an endoperoxide antimalarial agent with anticancer activity.1,2 It reduces the growth of various P. falciparum strains in vitro (IC50s = 3.98-20.36 nM) and reduces parasitemia in mice infected with P. falciparum with a curative dose (CD50) value of 140 mg/kg.1,3 It also reduces P. berghei infection in mice (ED50 = 5.6 mg/kg per day).4 Artemisinin (100-400 μM) induces cell cycle arrest in the G0/G1 phase and apoptosis and inhibits growth of SK-N-AS, BE(2)-C, SK-N-DZ, and SHEP1 neuroblastoma cells in a time- and concentration-dependent manner.2 It also suppresses BE(2)-C cell colony formation in a soft agar assay and reduces tumor growth in a BE(2)-C mouse xenograft model. Formulations containing artemisinin have been used in combination therapies for the treatment of malaria.

1.Akoachere, M., Buchholz, K., Fischer, E., et al.In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisininsAntimicrob. Agents Chemother.49(11)4592-4597(2005) 2.Zhu, S., Liu, W., Ke, X., et al.Artemisinin reduces cell proliferation and induces apoptosis in neuroblastomaOncol. Rep.32(3)1094-1100(2014) 3.Robert, A., Benoit-Vical, F., Claparols, C., et al.The antimalarial drug artemisinin alkylates heme in infected miceProc. Natl. Acad. Sci. U.S.A.102(38)13676-13680(2005) 4.Chawira, A.N., Warhurst, D.C., Robinson, B.L., et al.The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in miceTrans. R. Soc. Trop. Med. Hyg.81(4)554-558(1987)

Chemical Properties

Cas No. 176652-07-6 SDF
别名 Qinghaosu-d3; NSC 369397-d3
Canonical SMILES [H][C@]12[C@@H](C([2H])([2H])[2H])C(O[C@@]3([H])[C@@]1(OO4)[C@](CC[C@]4(C)O3)([H])[C@H](C)CC2)=O
分子式 C15H19D3O5 分子量 285.4
溶解度 DMSO: Slightly soluble,Methanol: Slightly soluble 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mM 3.5039 mL 17.5193 mL 35.0385 mL
5 mM 0.7008 mL 3.5039 mL 7.0077 mL
10 mM 0.3504 mL 1.7519 mL 3.5039 mL
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