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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC61802 ML380 ML380是一种有效的，亚型选择性和可透过血脑屏障的M5mAChR正变构调节剂(PAM)，对人和大鼠M5的EC50值分别为190和610nM。ML380对M1和M3mAChR亚型具有中等选择性。ML380可以增加Ach对M5mAChR的亲和力。
  3. GC61788 Etiocholanolone

    3a-羟基-5b-雄甾烷-17-酮,5β-Androsterone

     An androgenically inactive metabolite of testosterone and androstenedione
  4. GC61764 Teriflunomide impurity 3

    4-Amino-N-(4-trifluoromethylphenyl)benzamide

     Teriflunomideimpurity3(4-Amino-N-(4-trifluoromethylphenyl)benzamide)是一种选择性COX-1抑制剂，IC50为30µM，对COX-2的活性较低(IC50>100µM)。
  5. GC61751 Cycloleucine

    环亮氨酸

     Cycloleucine是一种S-腺苷甲硫氨酸介导的甲基化的特异性抑制剂。Cycloleucine是NMDA受体甘氨酸变构位点的拮抗剂，Ki值为600μM。Cycloleucine在体外也是ATP:L-蛋氨酸-S-腺苷基转移酶的竞争性抑制剂。Cycloleucine具有抗焦虑和抑制细胞作用。
  6. GC61742 Strictosidinic acid Strictosidinicacid是一种具有口服活性的，从Psychotriamyriantha叶中分离的糖苷吲哚单萜生物碱，抑制5-HT生物合成的前体酶并降低5-HT含量。Strictosidinicacid在小鼠中具有外周镇痛和解热活性。
  7. GC61689 Alminoprofen

    阿明洛芬,EB-382

     Alminoprofen是苯丙酸类非甾体抗炎药(NSAID)。Alminoprofen同时具有抑制分泌磷脂酶A2(sPLA2)活性和抗环氧化酶(COX-2)的活性。
  8. GC61624 Lesogaberan

    P-[(2R)-3-氨基-2-氟丙基]磷酸,AZD-3355

     Lesogaberan(AZD-3355)是一种有效的选择性GABAB受体激动剂，对人重组GABAB受体的EC50为8.6nM。对大鼠脑GABAB和GABAA受体的结合亲和力(Ki)分别为5.1nM和1.4μM。
  9. GC61593 DAPK Substrate Peptide TFA DAPKSubstratePeptideTFA是一种合成的死亡相关蛋白激酶(DAPK)的肽底物，Km为9μM。
  10. GC61580 Sepimostat

    司匹司他,FUT-187 free base

     Sepimostat(FUT-187freebase)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostat抑制Ifenprodil结合的Ki值为27.7 µM。
  11. GC61570 Sepimostat dimethanesulfonate

    6-甲脒基萘-2-基4-((4,5-二氢-1H-咪唑-2-基)氨基)苯甲酸酯二甲磺酸盐,FUT-187

     Sepimostatdimethanesulfonate(FUT-187)通过拮抗NR2BN-methyl-D-aspartate受体发挥神经保护作用，作用位点在NR2B亚基的Ifenprodil结合位点。Sepimostatdimethanesulfonate抑制Ifenprodil结合的Ki值为27.7 µM。
  12. GC61566 Pseudocoptisine chloride

    盐酸异黄连碱; Isocoptisine chloride

     Pseudocoptisine chloride (Isocoptisine chloride) is a quaternary alkaloid with benzylisoquinoline skeleton isolated from Corydalis Tuber, inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM, showing anti-inflammatory and anti-amnestic effects.
  13. GC61565 Indophagolin

    5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺

     Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  14. GC61539 Betazole

    倍他唑,Ametazole

     Betazole Dihydrochloride (Ametazole, 2-(3-Pyrazolyl)ethanamine) is a histamine H2 agonist used clinically to test gastric secretory function.
  15. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
  16. GC61486 Neurokinin A TFA

    Substance K TFA; Neurokinin α TFA; Neuromedin L TFA

     NeurokininATFA(SubstanceKTFA)是速激肽家族的一种肽类神经递质，通过NK-2受体发挥作用。在人气道和胃肠道组织中作为主要的介体。
  17. GC61476 Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2是一种选择性天冬酰胺内肽酶AEP抑制肽，可抑制淀粉样前体蛋白APP裂解。AEP是一种pH值控制的半胱氨酸蛋白酶，在衰老过程中被激活并介导APP蛋白水解过程。
  18. GC61467 Niaprazine

    尼普拉嗪

     Niaprazine是一种具有强效镇静作用的组胺H1受体(histamineH1-receptor)拮抗剂。Niaprazine具有抗组胺和抗血清素活性，并可用于睡眠障碍的研究。
  19. GC61464 GR 125743 GR125743是一种选择性的5-HT1B/1D受体拮抗剂，与野生型的人h5-HT1B和5-HT1D结合的pKi分别为8.85和8.31。GR125743可用于帕金森病和心血管疾病的研究。
  20. GC61453 Penconazole

    戊菌唑

     Penconazole是一种典型的三唑类杀菌剂(fungicide)，主要用于苹果、葡萄、蔬菜等地的白粉病防治。Penconazole抑制真菌固醇生物合成。Penconazole降低大鼠大脑和小脑AChE活性。
  21. GC61446 (Rac)-Lanicemine

    (Rac)-拉尼西明; (Rac)-AZD6765

     (Rac)-Lanicemine((Rac)-AZD6765)是Lanicemine的外消旋体。Lanicemine(AZD6765)是一种低捕获的NMDA受体拮抗剂，Ki为0.56-2.1 μM。CHO和爪蟾卵母细胞中，IC50分别为4-7μM和6.4μM。具有抗抑郁作用。
  22. GC61436 Gallic acid hydrate

    没食子酸-水合物; 3,4,5-Trihydroxybenzoic acid hydrate

     A phenol with diverse biological activities
  23. GC61401 Oxatomide

    欧诗美锭

     Oxatomide是一种有效的具有口服活性的双重H1组胺受体(H1-histaminereceptor)和P2X7受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide几乎完全阻断人P2X7受体中ATP诱导的电流(IC50为0.95μM)。Oxatomide可抑制ATP诱导的Ca2+内流，IC50值为0.43μM，并且还抑制5-羟色胺(serotonin)。
  24. GC19706 Propacetamol hydrochloride

    盐酸丙帕他莫

     A prodrug form of acetaminophen
  25. GC19695 2,8-Quinolinediol

    2,8-喹啉二醇

      
  26. GC19686 DL-Pyroglutamic acid

    DL-焦谷氨酸

      
  27. GC48962 Heptanoic Acid

    庚酸

     A medium-chain fatty acid
  28. GC48956 Penicillamine-d3

    D-(-)-Penicillamine-d3

     An internal standard for the quantification of penicillamine
  29. GC48954 CP21 An iron chelator
  30. GC48937 L-Tyrosine-13C9,15N

    DL-酪氨酸 13C9,15N

     An internal standard for the quantification of L-tyrosine
  31. GC48930 Tryptamine-d4 (hydrochloride)

    D4色胺盐酸

     An internal standard for the quantification of tryptamine
  32. GC48912 RO5166017 A TAAR1 agonist
  33. GC48907 Metaxalone-d6

    AHR438-d6; NSC170959-d6

     An internal standard for the quantification of metaxalone
  34. GC48897 Homocarnosine

    高肌肽; L-Homocarnosine; γ-Aminobutyryl-L-histidine

     A dipeptide
  35. GC48895 Rufinamide-15N-d2

    [15N,2H2]-卢非酰胺

     An internal standard for the quantification of rufinamide
  36. GC48892 NSC 19005

    N-甲基-N,N-双(2-吡啶基乙基)胺,NSC19005

     A potential impurity found in commercial preparations of betahistine
  37. GC48889 Methazolamide-d6

    L584601-d6

     An internal standard for the quantification of methazolamide
  38. GC48886 Carbamazepine-d10

    5H-二苯并[B,F]氮杂卓-5-甲酰胺-D10,CBZ-d10; NSC 169864-d10

     An internal standard for the quantification of carbamazepine
  39. GC48881 Tasimelteon-d5

    BMS-214778-d5; VEC-162-d5

     An internal standard for the quantification of tasimelteon
  40. GC48880 7-Methoxyflavone

    7-甲氧基黄酮

     A flavone with diverse biological activities
  41. GC48861 Phenytoin-d10

    苯妥英D10,5,5-Diphenylhydantoin-d10

     An internal standard for the quantification of phenytoin
  42. GC48858 APHS A COX inhibitor
  43. GC48853 Pirlindole-d4 (hydrochloride) An internal standard for the quantification of pirlindole
  44. GC48847 Oxprenolol-d7

    dl-Alprenolol-d7, dl-Oxprenolol-d7

     An internal standard for the quantification of oxprenolol
  45. GC48843 5α-Androst-16-en-3α-ol

    (3α,5α)-16-烯-3-甾醇

     A pheromone with diverse biological activities
  46. GC48835 Diphenylpyraline

    二苯拉林； 双苯拉林

     A histamine H1 receptor antagonist
  47. GC48827 Flufenamic Acid-d4

    FFA-d4, Fluphenamic Acid-d4

     An internal standard for the quantification of flufenamic acid
  48. GC48824 4-hydroxy Estrone

    4-羟基雌酮; 4-OHE1

     A metabolite of estrone
  49. GC48821 11-cis Retinol

    11-cis Vitamin A Alcohol

     An isomer of vitamin A
  50. GC48814 Mesembrine

    松叶菊碱,(+)-Mesembrine

     An alkaloid with 5-HT reuptake inhibitory activity
  51. GC48805 Methapyrilene (hydrochloride)

    盐酸美沙吡林,Thenylpyramine hydrochloride

     An H1 receptor antagonist and non-genotoxic carcinogen

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