Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for Chromatin/Epigenetics

Cat.No. 产品名称 Information
GC41695 (6R,S)-5,6,7,8-Tetrahydrofolic Acid (hydrochloride)
Tetrahydrofolate, THFA
A folic acid derivative
GC41638 TSI-01 TSI-01是溶血磷脂酰胆碱酰基转移酶2（LPCAT2）的选择性抑制剂，对人 LPCAT2和LPCAT1的IC₅₀值分别为0.47和3.02µM。
GC41625 Oroxylin A
千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein
A flavonoid with diverse biological activities
GC41601 CAY10591
SIRT1 Activator 3, Sirtuin 1 Activator 3
A SIRT1 activator
GC41572 PRLX-93936 An erastin analog with antitumor activity
GC41495 HDAC3 Inhibitor
Histone Deacetylase 3
An allosteric HDAC3 inhibitor
GC41263 TP-064 A potent inhibitor of PRMT4
GC41088 (6S)-Tetrahydrofolic Acid
An active diastereomer
GC41085 HDAC6 Inhibitor
Histone Deacetylase 6
An inhibitor of HDAC6
GC40923 BRD4884 A kinetically selective HDAC2 inhibitor
GC40918 Gramicidin A
甲胎蛋白
A channel-forming ionophore
GC40900 Ganoderic Acid D
灵芝酸 D
An oxygenated triterpenoid
GC40791 MS-1020 A cell-permeable inhibitor of JAK3
GC40767 CAY10669 An inhibitor of PCAF
GC40674 APHA Compound 8
组蛋白去乙酰化酶
A class I and II HDAC inhibitor
GC40667 Aurora Kinase Inhibitor II
4-(4-Benzamidoanilino)-6,7-dimethoxyquinazoline
Blocks Aurora A kinase activity
GC40628 TP-472 A BRD9 inhibitor
GC40555 Tiopronin
BRN 1859822, (±)-Tiopronin
Tiopronin is an antioxidant that has diverse biological activities.
GC40496 N6-Methyladenine
6-(甲氨基)嘌呤
A modified purine of microbial genomes
GC40468 1,5-Isoquinolinediol
1,5-二羟基异喹啉,NSC 65585
An inhibitor of poly(ADP-ribose) polymerases
GC19542 GeA-69 GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。
GC10456 Fucosterol
岩皂甾醇,24-ethylidene Cholesterol
A natural phytosterol with diverse biological activities
GC34849 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
GC34785 Sirt2-IN-1 Sirt2-IN-1(Compound9)是一种sirtuin2(Sirt2)抑制剂，IC50为163nM。
GC34784 Sinefungin
西奈芬净,Adenosyl-Ornithine; A-9145; Antibiotic 32232RP

Sinefungin是病毒mRNA(鸟嘌呤-7-)-甲基转移酶、mRNA(核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。Sinefungin是一种SET7/9抑制剂，通过抑制H3K4甲基化来改善肾纤维化。
GC34778 SGC-iMLLT An inhibitor of MLLT1 and MLLT3 YEATS domains
GC34742 Protosappanin A
原苏木素A; PTA

ProtosappaninA(PTA)，是一种免疫制剂，是从CaesalpiniasappanL中分离得到的一种主要联苯化合物，通过下调JAK2和STAT3的磷酸化，抑制JAK2/STAT3依赖的炎症通路。
GC34692 NU6140 A Cdk2 inhibitor
GC34675 Molibresib besylate
GSK 525762C; I-BET 762 besylate
Molibresibbesylate(GSK525762C;I-BET762besylate)是BET溴结构域抑制剂，IC50为32.5-42.5nM。
GC34629 J22352 J22352是一种具有类似靶向嵌合体蛋白水解(PROTAC)特性、高度选择性HDAC6抑制剂，其IC50值为4.7nM，J22352通过抑制胶质母细胞瘤自噬、诱发抗肿瘤免疫反应来促进HDAC6降解和诱导抗癌效果，并通过降低PD-L1的免疫抑制活性，使宿主抗肿瘤活性恢复。
GC34604 GSK467 GSK467 is a cell penetrant and selective inhibitor of KDM5B (JARID1B/PLU1) with Ki of 10 nM. GSK467 shows apparent 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other JmJ family members.
GC34595 GN44028 GN44028 是一种有效且具有口服活性的缺氧诱导因子 (HIF)-1α 抑制剂，IC50 为 14 nM。 GN44028 抑制缺氧诱导的 HIF-1α 转录活性，而不抑制 HIF-1α mRNA 表达、HIF-1α 蛋白积累或 HIF-1α/HIF-1β 异二聚化。 GN44028可用于癌症研究。
GC34568 EHMT2-IN-2 EHMT2-IN-2是一种有效的EHMT抑制剂，对对EHMT1多肽,EHMT2多肽和细胞内EHMT2的IC50值均小于100nM。可用于血液疾病或癌症的研究。
GC34567 EHMT2-IN-1 EHMT2-IN-1是一种有效的EHMT抑制剂，对EHMT1多肽,EHMT2多肽和细胞内EHMT2的IC50均小于100nM。用于血液疾病或癌症的研究。
GC34517 CBP-IN-1
CCS1477
A p300 and CBP inhibitor
GC34505 BRD7-IN-1 BRD7-IN-1是一种修饰的BI7273衍生物(BRD7/9抑制剂)，通过与VHL配体连接形成PROTACVZ185(VZ185抑制BRD7/9的DC50分别是4.5nM、1.8nM)。
GC34498 Bobcat339 hydrochloride A cytosine derivative
GC34458 ACY-1083
ACY-1083是一种可渗透脑的选择性HDAC6抑制剂，IC50为3nM，ACY-1083对HDAC6的选择性比其他类别的HDAC亚型高260倍。ACY-1083可有效逆转化疗引起的周围神经病变。
GC34446 (rac)-BAY1238097 (rac)-BAY1238097是一种BET抑制剂，对BRD4的IC50值为1.02μM。用于癌症研究。
GC34443 (R)-BAY1238097 (R)-BAY1238097是BAY1238097的低活性R型异构体。BAY1238097是一种有效的、BET与组蛋白结合的选择性抑制剂，通过下调c-Myc水平及下游转录组，在AML(急性髓性白血病)和MM(多发性骨髓瘤)模型中表现出较强的抗增殖活性。
GC19505 RK-287107 A TNKS1/2 inhibitor
GC40255 Citrulline-specific Probe-biotin An affinity probe for citrullinated proteins
GC40251 TCEP-biotin
Tris(2-carboxyethyl)phosphine-biotin
An affinity probe for protein lysine crotonylation
GC40226 Curcumin-d6
(1E,4Z,6E)-5-羟基-1,7-二[4-羟基-3-(甲氧基-D3)苯基]-1,4,6-庚三烯-3-酮,Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6
An internal standard for the quantification of curcumin
GC40117 Histone H2B (21-35) (human, mouse, rat, bovine) (trifluoroacetate salt)
AQKKDGKKRKRSRKE, AspH2B21-35, H2B21-35
A peptide fragment of histone H2B
GC40115 Histone H3K79Ac (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
EIAQDF-K(Ac)-TDLR, H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Ac)-Thr-Asp-Leu-Arg-OH, Histone H3 (73-83) (Lys79ac), H3K79Ac, Lys(Ac)79-Histone H3 (73-83)
A peptide fragment of histone H3
GC40114 Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
GC40113 Histone H3K9Ac (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)
ARTKQTAR-K(Ac)-STGGKAPRKQLATKA, H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Ac)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-OH, Histone H3 (1-24) (Lys9ac), Lys(Ac)9-Histone H3 (1-24)
A peptide fragment of histone H3
GC40111 Histone H3 (21-44) (human, mouse, rat, bovine) (trifluoroacetate salt)
ATKAARKSAPATGGVKKPHRYRPG
A peptide fragment of histone H3
GC40098 BB-Cl-Yne A clickable PAD inhibitor