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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC35447 AZD1208 hydrochloride A pan-Pim kinase inhibitor
  3. GC35297 Alobresib

    GS-5829

     A BET bromodomain inhibitor
  4. GC35230 Acetylarenobufagin

    乙酰沙蟾毒精

     Acetylarenobufagin 是一种类固醇缺氧诱导因子-1 (HIF-I) 调节剂。
  5. GC35227 ACBI1 ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
  6. GC35216 AAPK-25 AAPK-25 是一种有效选择性的 Aurora/PLK 激酶双重抑制剂，具有抗肿瘤活性。AAPK-25 可引起有丝分裂延迟并阻滞前中期细胞，通过生物标志物组蛋白 H3Ser10 磷酸化反应，随后细胞凋亡激增。AAPK-25 靶向 Aurora-A, -B, -C 的 Kd 值为 23 nM-289 nM，靶向 PLK-1, -2, -3 的 Kd 值为 55-456 nM。
  7. GC35180 6-Methyl-5-azacytidine

    阿扎胞苷杂质34

     6-Methyl-5-azacytidine 是一种有效的甲基转移酶抑制剂。
  8. GC35175 6-Demethoxytangeretin

    6-去甲氧基三苯甲基黄嘌呤

     6-?Demethoxytangeretin 6-去甲氧基三苯甲基黄嘌呤是从柑橘 (Citrus depressa) 分离的黄酮。 6-Demethoxytangeretin 具有抗炎和抗过敏活性，通过间变性淋巴瘤激酶 (ALK) 和丝裂原活化蛋白激酶 (MAPK) 途径抑制人肥大细胞中 IL-6 的产生和基因表达。6-?Demethoxytangeretin 促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。
  9. GC35150 5,7,4'-Trimethoxyflavone

    5,7,4'-三甲氧基黄酮

     4',5,7-Trimethoxyflavone (5,7,4'-Trimethoxyflavone, TMF) is a flavonoid isolated from Kaempferia parviflora (KP) that induces apoptosis. 4',5,7-Trimethoxyflavone increases sub-G1 phase, DNA fragmentation, annexin-V/PI staining and Bax/Bcl-xL ratio, activates caspase-3 and degrades poly (ADP-ribose) polymerase (PARP) protein.
  10. GC34973 (3S,4S)-Tofacitinib

    (3S,4S)-托法替尼

     Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
  11. GC34972 (3S,4R)-Tofacitinib

    (3S,4R)-托法替尼

     Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
  12. GC34971 (3R,4S)-Tofacitinib

    (3R,4S)-托法替尼

     Tofacitinib(CP-690550)是高效JAK3抑制剂，IC50为1 nM，比对JAK2和JAK1的抑制性高20倍和100倍。
  13. GC34964 (1S,3R,5R)-PIM447 dihydrochloride

    (1S,3R,5R)-LGH447 dihydrochloride

     (1S,3R,5R)-PIM447 (dihydrochloride)是PIM的抑制剂，来自专利US 20100056576 A1化合物实例72。对Pim1，Pim2和Pim3的IC50分别为0.095，0.522和0.369 μM。
  14. GC34958 (+)-JQ1 PA A clickable form of (+)-JQ1
  15. GC45258 (+)-Biotin 4-Amidobenzoic Acid (sodium salt)

    生物素4-氨基苯甲酸钠盐

     A biotinidase substrate
  16. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

     A metabolite of valproic acid
  17. GC45117 UNC2327 An allosteric inhibitor of PRMT3
  18. GC45116 UNC2170 (maleate) A 53BP1 antagonist
  19. GC45095 Tubastatin A (trifluoroacetate salt)

    N-羟基-4-((2-甲基-3,4-二氢-1H-吡啶并[4,3-B]吲哚-5(2H)-基)甲基)苯甲酰胺2,2,2-三氟乙酸盐

     A potent HDAC6 inhibitor
  20. GC45094 TTK21 An activator of CBP/p300 histone acetyltransferase activity
  21. GC45080 Trichostatin C

    曲古抑菌素C

     A glycosylated derivative of trichostatin A
  22. GC45005 TDFA (trifluoroacetate salt)

    Thr-Asp-F-amidine

     A PAD4 inhibitor
  23. GC44984 TAF 10 Peptide

    TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)Associated Factor, TBPAssociated Factor 10, TAFII30

     A peptide associated with RNA polymerase II activity
  24. GC44886 S-Farnesyl Thioacetic Acid

    FTA

     A competitive inhibitor of SAM-dependent methyltransferase
  25. GC44866 SAHA-d5

    SAHA-d5; Suberoylanilide hydroxamic acid-d5

     An internal standard for the quantification of SAHA
  26. GC44865 SAHA-BPyne

    Click Tag SAHA-BPyne, Suberoylanilide Hydroxamic AcidBPyne

     A probe for HDAC activity
  27. GC44859 S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

    5'-[[(3S)-3-氨基-3-羧基丙基]甲基锍]-5'-脱氧腺苷氯化物二盐酸盐

    Ubiquitous methyl donor
  28. GC44685 Procaine (hydrochloride)

    Novocaine

     Procaine (hydrochloride) is an analytical reference standard categorized as a local anesthetic that is used as an adulterant.
  29. GC44668 Posaconazole D-Glucuronide

    Posaconazole N-β-D-Glucuronide

     A metabolite of posaconazole
  30. GC44477 NVS-CECR2-1

    NVS-1

     A potent and selective CECR2 inhibitor
  31. GC44401 Nicotinamide riboside

    烟酰胺核糖

     烟酰胺核苷是维生素 B3 和 NAD+ 前体的一种形式，通过烟酰胺核苷激酶 (NRK) 和 NMNAT，或通过核苷磷酸化酶和 NAM 补救作用，转化为生物可利用的 NAD+.在体外实验中，烟酰胺核苷通过激活 SirT1/PGC-1α/线粒体生物合成途径减轻酒精引起的肝损伤。
  32. GC44250 MS351

    MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain.
  33. GC44184 Methylstat (hydrate) A cell-permeable demethylase inhibitor
  34. GC43889 I-CBP112 (hydrochloride) A p300 and CBP inhibitor
  35. GC43865 Histone H4 Peptide Substrate (15-24)

    Histone H4K20 Peptide, SET8 Methyltransferase Acceptor Peptide

     Substrate for acceptor peptide SET8
  36. GC43864 Histone H4 Peptide Substrate (1-21)

    H4 Peptide

     Target substrate for several histone modifying enzymes
  37. GC43863 Histone H3K9Me3 (1-24) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ARTKQTAR-K(Me3)-STGGKAPRKQLATKA, H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-OH, H3K9me3, Lys(Me3)9-Histone H3 (1-24), Histone H3 (1-24) (Lys9me3)

     A peptide fragment of histone H3
  38. GC43862 Histone H3K9Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ARTKQTAR-K(Me3)-STGGKAPRKQLA, H-Ala-Arg-Thr-Lys-Gln-Thr-Ala-Arg-Lys(Me3)-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-OH, Lys(Me3)9-Histone H3 (1-21), Histone H3 (1-21) (Lys9me3), H3K9me3

     A peptide fragment of histone H3
  39. GC43861 Histone H3K9Ac (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ARTKQTAR-K(Ac)-STGGKAPRKQLA, Histone H3 (1-21) (Lys9ac), Lys(Ac)9-Histone H3 (1-21)

     A peptide fragment of histone H3
  40. GC43860 Histone H3K9Ac (1-20) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ARTKQTAR-K(Ac)-STGGKAPRKQL, Histone H3 (1-20) (Lys9ac), Lys(Ac)9-Histone H3 (1-20)

     A peptide fragment of histone H3
  41. GC43859 Histone H3K79Me3 (73-83) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    EIAQDF-K(Me3)-TDLR, H3K79me3, Histone H3 (73-83) (Lys79me3), H-Glu-Ile-Ala-Gln-Asp-Phe-Lys(Me3)-Thr-Asp-Leu-Arg-OH, Lys(Me3)79-Histone H3 (73-83)

     A peptide fragment of histone H3
  42. GC43858 Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me3)-QTARKSTGGKAPRKQLA, H3K4(Me3), Histone H3 (1-21) (Lys4me3), Lys(Me3)4-Histone H3 (1-21)

    A peptide fragment of histone H3
  43. GC43857 Histone H3K4Me2 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me2)-QTARKSTGGKAPRKQLA, Histone H3 (1-21) (Lys4me2), Lys(Me2)4-Histone H3 (1-21)

     A peptide fragment of histone H3
  44. GC43856 Histone H3K4Me2 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me2)-QTARKS, H-Ala-Arg-Thr-Lys(Me2)-Gln-Thr-Ala-Arg-Lys-Ser-OH, Histone H3 (1-10) (Lys4me2), Lys(Me2)4-Histone H3 (1-10)

     A peptide fragment of histone H3
  45. GC43855 Histone H3K4Me1 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me1)-QTARKSTGGKAPRKQLA, Histone H3 (1-21) (Lys4me1), Lys(Me1)4-Histone H3 (1-21)

     A peptide fragment of histone H3
  46. GC43854 Histone H3K4Me1 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me1 (1-10) is an N-terminal fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
  47. GC43853 Histone H3K36Me3 (21-44)-GK-biotin (trifluoroacetate salt)

    ATKAARKSAPATGGV-K(Me3)-KPHRYRPG-GK(Biotin), Histone H3 (21-44) (Lys36me3), Lys(Me3)36-Histone H3 (21-44)-GK(Biotin)

     A biotinylated peptide fragment of histone H3
  48. GC43852 Histone H3K36Me2 (21-44)-GK-biotin (trifluoroacetate salt)

    ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin), Lys(Me2)36-Histone H3 (21-44)-GK(Biotin), Histone H3 (21-44) (Lys36me2)-biotin

     A biotinylated peptide fragment of histone H3
  49. GC43851 Histone H3K27Me3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt)

    Lys(Me3)27-Histone H3 (23-34), Histone H3 (23-34) (Lys27me3), KAAR-K(Me3)-SAPATGG

     A peptide fragment of histone H3
  50. GC43850 Histone H3K27Me3 (21-44)-K-biotin (trifluoroacetate salt)

    ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-K(Biotin), H3(21-44)K27me3 Substrate, Histone H3 (21-44) (Lys27me3), Lys(Me3)27-Histone H3 (21-44)-K(Biotin)

     A biotinylated peptide fragment of histone H3
  51. GC43849 Histone H3K27Me3 (21-44)-GK-biotin (trifluoroacetate salt)

    ATKAAR-K(Me3)-SAPATGGVKKPHRYRPG-GK(Biotin), H3(21-44)K27me3 Substrate, Histone H3 (21-44) (Lys27me3), Lys(Me3)27-Histone H3 (21-44)-GK(Biotin)

     A biotinylated peptide fragment of histone H3

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