Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC17599 Haloperidol
氟哌啶醇
Haloperidol是一种典型的抗精神病药和多巴胺D2样受体拮抗剂，也是离子通道抑制剂，可抑制多种离子通道，如G蛋白激活的内向整流钾通道、钙激活钾通道、HERG和HEAG钾通道以及L、N和P型钙通道。
GC10659 Fosaprepitant dimeglumine salt
福沙吡坦二甲葡胺; MK-0517; L785298
A prodrug form of aprepitant
GC16246 Fosaprepitant
福沙吡坦; L-758298
A prodrug form of aprepitant
GC12091 SB742457
3-苯基磺酰基-8-(哌嗪-1-基)喹啉,SB-742457; GSK-742457; RVT-101
A 5-HT₆ receptor antagonist
GC16797 Escitalopram Oxalate
依他普仑草酸盐; (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate
A selective serotonin reuptake inhibitor
GC13161 Escitalopram
艾司西酞普兰; (S)-Citalopram; (S)-(+)-Citalopram
A selective serotonin reuptake inhibitor
GC13533 Cisapride
西沙比利; R 51619; (±)-Cisaprid
A 5-HT₄ receptor agonist
GC14096 Aclidinium Bromide
阿地溴铵; LAS 34273; LAS-W 330
A muscarinic acetylcholine receptor antagonist
GC15434 A 839977 A P2X₇ receptor antagonist
GC16819 VU0152100
3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺,VU152100
A muscarinic M₄ receptor positive allosteric modulator
GC17130 BRL-54443
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
A potent agonist of 5-HT_1E and 5-HT_1F
GC17184 Ambrisentan
安倍生坦; BSF 208075; LU 208075
An ET_A receptor antagonist
GC10621 Biperiden HCl
盐酸比哌立登; KL 373 hydrochloride

A muscarinic acetylcholine receptor antagonist
GC16226 BRL-15572 dihydrochloride
BRL15572盐酸盐
A 5-HT_1D receptor antagonist
GC16986 SDZ 220-581 hydrochloride
(S)-ALPHA-氨基-2'-氯-5-(膦酰甲基)-[1,1'-联苯]-3-丙酸盐酸盐
SDZ 220-581 hydrochloride 是一种口服有效的竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
GC11643 PNU-120596
NSC 216666
PNU-120596是α7神经元烟碱乙酰胆碱受体（α7nAChR）的正变构调节剂，EC₅₀值为216nM。
GC17769 Sitaxentan sodium
西他生坦钠,IPI 1040 sodium; TBC11251 sodium
Sitaxentan sodium是一种选择性内皮素A受体（ETA）拮抗剂（IC₅₀ = 1.4nM；K_i = 0.43nM）。
GC17695 Aniracetam
茴拉西坦; Ro 13-5057
An Analytical Reference Standard
GC11192 MK-3207 HCl
(8R)-8-(3,5-二氟苯基)-10-氧代-N-[(2R)-1,1',2',3-四氢-2'-氧代螺[2H-茚-2,3'-[3H]吡咯并[2,3-B]吡啶]-5-基]-6,9-二氮杂螺[4.5]癸烷-9-乙酰胺盐酸盐
MK-3207 (Hydrochloride) 是一种有效的口服生物可利用的 CGRP 受体拮抗剂，IC50 为 0.12 nM，Ki 为 0.024 nM，对人 AM1、AM2、CTR 和 AMY3 具有高度选择性。
GC16143 Varenicline Hydrochloride
6,7,8,9-四氢-6,10-甲桥-6H-吡嗪并[2,3-H][3]苯并氮杂卓盐酸盐,CP 526555 hydrochloride
Varenicline Hydrochloride (CP 526555 hydrochloride) 是一种高亲和力、选择性的 α4β2 尼古丁乙酰胆碱受体 (nAChR) 部分激动剂和完整的 α7 nAChR 激动剂。
GC12762 Varenicline
伐尼克兰; CP 526555
Varenicline (CP 526555) 是一种有效的 α4β2 烟碱乙酰胆碱受体 (nAChR) 部分激动剂，EC50 值为 2.3 μM。
GC10264 Arecoline hydrobromide
氢溴酸槟榔碱
Muscarinic acetylcholine receptor agonist
GC14714 Bupropion hydrochloride
盐酸氨非他酮; Amfebutamone hydrochloride
An Analytical Reference Material
GC10698 Cyproheptadine hydrochloride
盐酸赛庚啶
An antihistamine with antiserotonergic and anticholinergic activities
GC10198 Memantine hydrochloride
盐酸美金刚; D-145 hydrochloride
An NMDA receptor antagonist
GC10575 RJR-2403 hemioxalate Neuronal nicotinic receptor agonist
GC13322 Vanoxerine
GBR 12909; I893
Vanoxerine (GBR-12909) 是一种竞争性、强效和高度选择性的多巴胺再摄取抑制剂 (Ki=1 nM)。
GC17741 Vanoxerine dihydrochloride
伐诺司林二盐酸盐,GBR-12909 dihydrochloride; I893 dihydrochloride
An inhibitor of dopamine uptake
GC17456 NMDA (N-Methyl-D-aspartic acid)
N-甲基-D-天冬氨酸; N-Methyl-D-aspartic acid
An excitatory neurotransmitter
GC13793 NH125 An antibacterial imidazole
GC12391 Xanthohumol
黄腐醇

A natural prenylated chalcone
GC12717 Ipratropium Bromide
异丙托溴铵; Sch 1000
A muscarinic receptor antagonist
GC13871 Duloxetine HCl
盐酸度洛西汀; (S)-Duloxetine hydrochloride; LY-248686 hydrochloride
A serotonin and norepinephrine reuptake inhibitor
GC14984 Diphenylpyraline HCl
盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride
A histamine H₁ receptor antagonist
GC16635 Diphemanil Methylsulfate
甲硫二苯马尼,Diphemanil mesylate
An anticholinergic agent
GC15312 Chlorprothixene
氯普噻吨
A dopamine D₂ receptor antagonist
GC10624 Carbenoxolone disodium
甘珀酸钠
An 11β-HSD inhibitor
GC14160 Blonanserin
布南色林; AD-5423
A dopamine and serotonin receptor antagonist
GC11977 Thioridazine HCl
盐酸硫利达嗪；盐酸硫代利哒；甲硫达嗪盐酸盐；甲硫哒嗪盐酸盐
A typical antipsychotic
GC10978 Terfenadine
特非那定; (±)-Terfenadine; MDL-991
A selective histamine H₁-receptor antagonist
GC10460 Rizatriptan Benzoate
苯甲酸利扎曲坦,MK 462
A 5-HT_1B and 5-HT_1D receptor agonist
GC12994 Rivastigmine Tartrate
酒石酸卡巴拉汀; ENA 713; SDZ-ENA 713
A cholinesterase inhibitor
GC12986 Risperidone
利培酮; R 64 766
An atypical antipsychotic
GC13802 Riluzole
利鲁唑; PK 26124
Riluzole 是一种抗惊厥药，属于使用依赖性 Na+ 通道阻滞剂家族，它也可以抑制 GABA 摄取，IC50 为 43 μM。
GC16790 Piroxicam
吡罗昔康; CP-16171
A COX inhibitor and NSAID
GC10112 Paliperidone
9-羟基利培酮; 9-Hydroxyrisperidone
An atypical antipsychotic
GC14113 Oxybutynin
奥昔布宁
An antagonist of muscarinic acetylcholine receptors
GC11762 Meloxicam (Mobic)
美洛昔康
A selective COX-2 inhibitor
GC17227 LY2886721
N-[3-[(4AS,7AS)-2-氨基-4A,5-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(7H)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺
An inhibitor of BACE
GC15095 Levodopa
左旋多巴; Levodopa; 3,4-Dihydroxyphenylalanine
A dopamine precursor