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Aclidinium Bromide Sale

(Synonyms: 阿地溴铵; LAS 34273; LAS-W 330) 目录号 : GC14096

A muscarinic acetylcholine receptor antagonist

Aclidinium Bromide Chemical Structure

Cas No.:320345-99-1

规格 价格 库存 购买数量
10mM (in 1mL DMSO) 待询 待询
5mg
¥540.00
现货
10mg
¥855.00
现货
50mg
¥2,655.00
现货
100mg
¥4,455.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Aclidinium Bromide is a long-acting antagonist of muscarinic (LAMAs) [1].

Aclidinium Bromide has been reported to inhibit the specific binding of [3H]-NMS to human M receptors in a dose-denpendent fasion with Ki values of 0.10±0.00nM,0.14±0.04nM, 0.14±0.02nM, 0.21±0.04nM and 0.16±0.01nM for M1, M2,M3,M4 and M5, respectively. In addition, Aclidinium Bromide has shown the great potency at endogenous M2 and M3 receptors with EC50 values of 17.4±1.1nM and 5.3±1.6nM, respectively. Apart from these, Aclidinium Bromide has been revealed to produce a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction in vivo with an EC50 of ranging from 2.5 to 23.1μg/mL in anaesthetized guines pigs. Besides, Aclidinium Bromide has also been noted to inhibit the salivation in rat pilocarpine-induced sialorrhea model with an EC50 of 38μg/kg [1].

References:
[1] Gavaldà A1, Ramos I2, Carcasona C3, Calama E4, Otal R5, Montero JL6, Sentellas S7, Aparici M8, Vilella D9, Alberti J10, Beleta J11, Miralpeix M12. The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide. Pulm Pharmacol Ther. 2014 Aug;28(2):114-21.

Chemical Properties

Cas No. 320345-99-1 SDF
别名 阿地溴铵; LAS 34273; LAS-W 330
化学名 [(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide
Canonical SMILES C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]
分子式 C26H30BrNO4S2 分子量 564.55
溶解度 ≥ 28.2275mg/mL in DMSO 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.7713 mL 8.8566 mL 17.7132 mL
5 mM 0.3543 mL 1.7713 mL 3.5426 mL
10 mM 0.1771 mL 0.8857 mL 1.7713 mL
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