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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC31018 NEO 376 (SPI-376)

    SPI-376

     NEO 376 (SPI-376) 是 5-HT1 受体、GABA 受体和多巴胺受体的选择性调节剂，具有抗精神病活性。
  3. GC31017 ENS-163 phosphate (ENS 213-163)

    ENS 213-163; Sandoz ENS 163 phosphate; Thiopilocarpine phosphate

     ENS-163 phosphate (ENS 213-163) 是一种选择性毒蕈碱 M1 受体激动剂。
  4. GC31015 NRA-0160 NRA-0160是一种选择性的dopamineD4receptor拮抗剂，Ki值为0.48nM；同时对dopamineD2receptor，D3receptor，大鼠5-HT2Areceptor和α1adrenoceptor分别具有不同程度的亲和度，Ki值分别为>10000nM，39nM，180nM和237nM。
  5. GC31014 Irindalone (Lu 21-098)

    茚达酮,Lu 21-?098

     Irindalone (Lu 21-098) 是一种新型血清素 5-HT2 拮抗剂。
  6. GC31013 U-101017 (PNU 101017)

    PNU 101017

     U-101017 (PNU 101017) 是苯二氮卓受体和 GABAA 受体的部分激动剂，具有抗焦虑作用。
  7. GC31011 FK1052 hydrochloride

    (±)-FK1052

     FK1052 hydrochloride ((±)-FK1052) 是 Fabesetron hydrochloride 的消旋体，是一种有效的 5-HT3 和 5-HT4 受体双重拮抗剂。
  8. GC31010 AZD-6280 AZD-6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder.
  9. GC31004 Temiverine hydrochloride

    盐酸替米维林

    Temiverinehydrochloride是一种合成的抗胆碱剂。
  10. GC31001 Pilocarpine nitrate

    硝酸毛果芸香碱

     Pilocarpinenitrate是一种选择性的M3型毒蕈碱乙酰胆碱受体(M3muscarinicreceptor)激动剂。
  11. GC30999 Pimethixene (Pimetixene)

    匹美噻吨,Pimetixene

     Pimethixene (Pimetixene) 是抗组胺药和抗血清素能化合物，用作抗偏头痛剂。
  12. GC30996 Alvameline (Lu 25-109)

    Lu 25-109

     Alvameline (Lu 25-109) (Lu25-109) 是一种部分 M1 激动剂和 M2/M3 拮抗剂。
  13. GC30995 CGP 25454A CGP25454A是一个新颖和选择性的突触前多巴胺自受体拮抗剂。
  14. GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)

    盐酸帕罗西汀半水合物; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

     Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
  15. GC30989 Bromperidol (R-11333)

    溴哌利多,R-11333

    An Analytical Reference Standard
  16. GC30988 TB5

    A potent and selective MAO-B inhibitor
  17. GC30983 alpha-Asarone (α-Asarone)

    α-细辛脑; α-Asarone; trans-Asarone

     An inhibitor of HMG-CoA reductase and CYP450 isoforms
  18. GC30982 Eltoprazine (DU 28853)

    1-(2,3-二氢-1,4-苯并二烷-5-基)哌嗪盐酸盐,DU 28853

     Eltoprazine (DU 28853)(DU28853) 是一种安定或抗侵袭剂，可作为 5-HT1A 和 5-HT1B 受体的激动剂和 5-HT2C 受体的拮抗剂。
  19. GC30981 Amitifadine hydrochloride (DOV-21947 hydrochloride)

    DOV-21947 hydrochloride; EB-1010 hydrochloride

    Amitifadine hydrochloride (DOV-21947 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺再摄取抑制剂 (SNDRI)，在 HEK 293 细胞中对 5-羟色胺、去甲肾上腺素和多巴胺的 IC50 分别为 12、23、96 nM。
  20. GC30980 Pardoprunox hydrochloride (SLV-308 hydrochloride)

    盐酸帕多芦诺,SLV-308 hydrochloride; DU-126891 hydrochloride

     A dopamine D2 and D3 receptor partial agonist and 5-HT1A agonist
  21. GC30979 Lazabemide (Ro 19-6327)

    拉扎贝胺; Ro 19-6327

     An inhibitor of MAO-B
  22. GC30976 Modaline sulfate

    硫酸莫达林

     Modaline硫酸盐是MAO抑制剂,用于治疗抑郁症。
  23. GC30975 Tiapride hydrochloride

    盐酸硫必利

     Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
  24. GC30974 Promazine hydrochloride

    盐酸丙嗪; Romtiazin hydrochloride; Ampazine hydrochloride; Berophen hydrochloride

     Promazine (Romtiazin, Sinophenin) is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
  25. GC30973 Mephenesin

    甲酚甘油醚

     Mephenesin (Decontractyl, Cresoxydiol, Memphenesin, Mephedan) is centrally acting muscle relaxant, a topical analgesic and may be an NMDA receptor antagonist.
  26. GC30972 Lidanserin (ZK-33839)

    利丹色林,ZK-33839

     Lidanserin (ZK-33839) (ZK-33839) 作为 5-HT2A 和 α1-肾上腺素能受体拮抗剂起作用。
  27. GC30971 Rapacuronium bromide (Org 9487)

    Org 9487

     雷帕库溴铵 (Org 9487) (Org 9487) 是一种非去极化神经肌肉阻滞剂，是毒蕈碱乙酰胆碱受体 (mAChR) 的变构调节剂。
  28. GC30968 Metixene hydrochloride hydrate

    美噻吨盐酸盐水合物；甲哌噻吨盐酸盐水合物

     Metixenehydrochloridehydrate是一种抗胆碱能、抗帕金森剂，能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体(muscarinicreceptor)结合，IC50和Kd值分别为55nM和15nM。
  29. GC30964 Vabicaserin hydrochloride (SCA 136)

    SCA 136

     Vabicaserin hydrochloride (SCA 136) 是一种 5-羟色胺 2C (5-HT2C) 受体选择性激动剂，EC50 为 8 nM。
  30. GC30963 Eprobemide (LIS 630)

    依普贝胺,LIS 630

     Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.
  31. GC30955 Cimetropium Bromide (DA-3177)

    西托溴铵; DA-3177

     Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂，用于长期治疗肠易激综合征。
  32. GC30953 Phenylbiguanide (N-Phenylbiguanide)

    1-苯基双胍,N-Phenylbiguanide; PBG; 1-Phenylbiguanide

     1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide) is a 5-hydroxytryptamine3 (5-HT3) receptor agonist with EC50 of 3.0 μM.
  33. GC30952 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine是一种有效的淀粉样蛋白显像剂，其与淀粉样蛋白Amyloid-β(1-40)结合的KD值为1.7nM。
  34. GC30951 MDL 105519

    3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸

     MDL105519是有效和选择性的甘氨酸与NMDA受体结合的拮抗剂。
  35. GC30949 Minaprine dihydrochloride

    米那卜林二盐酸盐

     Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂，还对乙酰胆碱酯酶有微弱抑制，抗抑郁类化合物。
  36. GC30948 Chlorphenoxamine

    氯苯沙明；氯苯氧胺

     Chlorphenoxamine是一种抗组胺剂和抗胆碱能药,用作抗帕金森氏病。
  37. GC30946 Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid)

    丙环定盐酸盐; Tricyclamol hydrochloride; (±)-Procyclidine hydrochloride

     A muscarinic acetylcholine receptor antagonist
  38. GC30945 Y1 receptor antagonist 1

    H 409-22 isomer

    Y1receptorantagonist1是H-409/22的一个异构体，是神经肽(neuropeptideY1)受体拮抗剂。
  39. GC30944 Sultopride hydrochloride (LIN-1418 hydrochloride)

    盐酸舒必利; LIN-1418 hydrochloride

     Sultopride hydrochloride (LIN-1418 hydrochloride) (LIN-1418 hydrochloride) 是多巴胺 D2 受体的选择性拮抗剂。
  40. GC30943 6,2'-Dihydroxyflavone

    6,2-二羟基黄酮

     6,2'-Dihydroxyflavone是一个新型的GABAA受体拮抗剂。
  41. GC30939 Eptapirone (F 11440)

    F 11440

     A potent and selective 5-HT1A receptor agonist
  42. GC30933 (+)-Kavain

    醉椒素

     A kavalactone with diverse biological activities
  43. GC30930 DAA-1106

    N-(2,5-二甲氧基苄基)-N-(5-氟-2-苯氧基苯基)乙酰胺

     A TSPO agonist
  44. GC30926 Lurasidone (SM-13496)

    鲁拉西酮; SM-13496

     An atypical antipsychotic
  45. GC30925 Benzetimide hydrochloride (R4929)

    盐酸苄替米特,R4929

    A muscarinic acetylcholine receptor antagonist
  46. GC30920 K 01-162 (K162)

    K162

     K 01-162 (K162) (K162) 抑制 Aβ 的原纤维形成；肽并消除其神经毒性。
  47. GC30912 Piperidolate hydrochloride

    盐酸哌立度酯

     Piperidolate盐酸盐是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。
  48. GC30911 Apimostinel (NRX-1074)

    NRX-1074; AGN-241660

    Apimostinel (NRX-1074) (NRX-1074; AGN-241660) 是一种具有口服活性的 NMDA 受体部分激动剂。
  49. GC30910 Eucalyptol (1,8-Cineole)

    NSC 6171

     Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
  50. GC30908 Drofenine hydrochloride (Hexahydroadiphenine hydrochloride)

    盐酸六氢芬宁,Hexahydroadiphenine hydrochloride

     Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers.
  51. GC30907 AVN-492 A 5-HT6 receptor antagonist

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