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CGP 25454A Sale

目录号 : GC30995

CGP25454A是一个新颖和选择性的突触前多巴胺自受体拮抗剂。

CGP 25454A Chemical Structure

Cas No.:104391-26-6

规格 价格 库存 购买数量
5 mg
¥2,520.00
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10 mg
¥4,320.00
现货
50 mg
¥8,640.00
现货
100 mg
¥14,850.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist. In vitro: CGP 25454A increase the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh.In vivo: CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA, the effect of CGP 25454A most probably reflects an enhanced release of DA under in vivo conditions. At 30-100 mg/kg, CGP 25454A inhibit [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors.

[1]. Bischoff S et al. CGP 25454A, a novel and selective presynaptic dopamine autoreceptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep;350(3):230-8.

Chemical Properties

Cas No. 104391-26-6 SDF
Canonical SMILES O=C(NCCN(CC)CC)C1=CC(C#N)=C(Cl)C=C1OC.[H]Cl
分子式 C15H21Cl2N3O2 分子量 346.25
溶解度 DMSO : ≥ 3.5 mg/mL (10.11 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.8881 mL 14.4404 mL 28.8809 mL
5 mM 0.5776 mL 2.8881 mL 5.7762 mL
10 mM 0.2888 mL 1.444 mL 2.8881 mL
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