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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC61238 Rehmapicrogenin

    地黄苦苷元

    Rehmapicrogenin可从Rehmanniaglutinosa的根部分离得到，通过抑制iNOS、COX-2和IL-6表现出有效的抗炎作用。
  3. GC61235 Regaloside B

    王百合苷 B

     RegalosideB是一种从Liliumlongiflorum中分离出来的苯丙烷。RegalosideB可以抑制iNOS和COX-2的表达，具有抗炎活性。
  4. GC61234 Rebamipide D4

    瑞巴派特 D4; OPC12759-d4; Proamipide-d4

     An internal standard for the quantification of rebamipide
  5. GC61206 Profenofos

    丙溴磷

     Profenofos是一种乙酰胆碱酯酶抑制有机磷农药，广泛应用于农田作物、蔬菜和水果作物。
  6. GC61193 Piroxicam D3

    吡罗昔康 D3; CP-16171 D3

     An internal standard for the quantification of piroxicam
  7. GC61186 Picrotoxinin

    木防己苦毒宁

     Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAAA receptors.
  8. GC61180 Phenidone

    菲尼酮

     Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer.
  9. GC61167 Paliperidone palmitate

    棕榈酸帕利哌酮,9-Hydroxyrisperidone palmitate

     Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
  10. GC61162 Osthenol

    7-羟基-8-(3-甲基-2-丁烯)-二氢苯并吡喃,Ostenol

     Osthenol(Ostenol)是从独活干根中分离得到的一种前酰化香豆素，是一种可逆的，选择性的竞争性人单胺氧化酶-A(hMAO-A)抑制剂(Ki=0.26µM)。Osthenol对重组hMAO-A具有潜在的选择性抑制作用，IC50为0.74µM，对hMAO-A和hMAO-B表现出较高的选择性指数。
  11. GC61108 Naftidrofuryl oxalate

    草酸萘呋胺; Nafronyl oxalate salt

     Naftidrofuryloxalate(Nafronyloxalatesalt)是在外周血和脑血管病症如血管扩张药的管理中使用的药物,增加细胞氧化能力,且是一种5-HT2受体拮抗剂。
  12. GC61067 Mirtazapine D3

    米氮平 D3; Org3770 D3; 6-Azamianserin D3

     An Analytical Reference Material
  13. GC61038 Mefenamic acid D4

    甲芬那酸 D4

     An internal standard for the quantification of mefenamic acid
  14. GC61017 Lycoramine hydrobromide

    石蒜胺；氢溴酸二氢加兰他敏

     Lycoraminehydrobromide是一种从Lycorisradiate中分离出的加兰他敏的二氢衍生物。Lycoraminehydrobromide是一种有效的乙酰胆碱酯酶(AChE)抑制剂。
  15. GC60966 Ketorolac D5

    酮咯酸D5

     An internal standard for the quantification of ketorolac
  16. GC60965 Keto Ziprasidone KetoZiprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  17. GC60957 Jatrorrhizine hydroxide Jatrorrhizine (Neprotin, Yatrorizine), one of the active constituents of Coptis chinensis Franch, has multiple bioactivities, such as hypoglycemic, antimicrobial, and antioxidant activities. It is an inhibitor of AChE with IC50 of 872 nM and demonstrates >115-fold selectivity for AChE over BuChE.
  18. GC60939 Iproniazid

    异丙烟肼

     Iproniazid (Marsilid, Iprazid) is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.
  19. GC60938 Iprindole

    伊普吲哚

     Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
  20. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  21. GC60926 Ibuprofen impurity 1

    布洛芬杂质

     Ibuprofenimpurity1是Ibuprofen的杂质。Ibuprofen是COX-1和COX-2的抑制剂，IC50值分别为13μM和370μM，具有抗炎的活性。
  22. GC60924 Hydroxyzine D8

    安泰乐D8

     An internal standard for the quantification of hydroxyzine
  23. GC60917 Hydroxyamine hydrochloride

    羟胺盐酸盐

     Hydroxylammonium chloride (Hydroxylamine hydrochloride) is the hydrochloric acid salt of hydroxylamine, which is a biological intermediate in the nitrification and in the anammox.
  24. GC60915 Hydroxy ziprasidone

    齐拉西酮羟基化杂质

     Hydroxyziprasidone是Ziprasidone的杂质。Ziprasidone，一种抗精神药物，是5-HT和多巴胺(dopaminereceptor)受体拮抗剂。
  25. GC60913 Huperzine C

    石杉碱丙

     HuperzineC是从Huperziaserrate中分离的一种生物碱。HuperzineC是一种乙酰胆碱酯酶(AChE)抑制剂，其IC50值为0.6μM。HuperzineC可用于阿尔茨海默症的研究。
  26. GC60890 Guvacine

    去甲槟榔次碱

     An inhibitor of GABA uptake
  27. GC60886 GSK356278 A selective PDE4 inhbitor
  28. GC60875 GKT136901

    NOX Inhibitor IV

     A dual inhibitor of NOX1 and NOX4
  29. GC60866 Gap 26 TFA Gap 26, a connexin mimetic peptide that composeds of residue no. 63-75 of the extracellular loop 1 of connexin 43 (Cx43), is a gap junction inhibitor. Gap 26 blocks photoliberating inositol-1,4,5-trisphosphate triggers ATP release.
  30. GC60862 GABAA receptor agent 1

    2-(4-氯苯基)-6-硝基-1H-苯并[D]咪唑

     GABAA receptor agent 1 is a high affinity ligand for Gamma-aminobutyric acid A (GABAA) receptor that exerts potent anticonvulsant activity.
  31. GC60846 Flesinoxan

    氟辛克生

     Flesinoxan是一种降压剂，是一种有效的，高亲和力的选择性的5-羟色胺1A(5-HT1A)受体激动剂，EC50值为24nM。Flesinoxan还具有有效的抗焦虑/抗抑郁作用。
  32. GC60791 Doxepin D3 Hydrochloride

    盐酸多塞平 D3

     DoxepinD3Hydrochloride是DoxepinHydrochloride的氘代物。Doxepinhydrochloride是一种口服活性的三环抗抑郁药。Doxepinhydrochloride是一种有效的选择性组胺受体H1拮抗剂。Doxepinhydrochloride也是一种有效的CYP450抑制剂，并显着抑制CYP4502C19和CYP4501A2。
  33. GC60774 Dihydro Donepezil

    盐酸多奈哌齐二氢杂质,Dihydro E2020

     DihydroDonepezil(DihydroE2020)是Donepezil的代谢产物。Donepezil是一种有效的特异性AChE抑制剂，对bAChE和hAChE的IC50分别为8.12nM和11.6nM。
  34. GC60758 Deschloroclozapine

    氯氮平杂质

     Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.
  35. GC60740 Dapoxetine-D7 hydrochloride

    LY-210448-d7 hydrochloride

     Dapoxetine-D7(LY-210448-D7)hydrochloride是Dapoxetinehydrochloride的氘代物。Dapoxetinehydrochloride是一种短效的选择性5-羟色胺再摄取抑制剂(SSRI)。
  36. GC60723 COR659 COR659是GABAB的阳性变构调节剂(PAM)。COR659可缓解大鼠对酒精和巧克力的药物成瘾。
  37. GC60709 Cinnarizine D8

    桂利嗪 D8

     An internal standard for the quantification of cinnarizine
  38. GC60691 Cetirizine Impurity C

    西替利嗪杂质C

     CetirizineImpurityC是Cetirizine的一种杂质。Cetirizine是羟嗪的羧化代谢物，是第二代抗组胺剂。Cetirizine是一种特异的、具有口服活性的H1受体(histamineH1-receptor)的长效拮抗剂。
  39. GC60662 Brexpiprazole S-oxide

    依匹哌唑硫氧化杂质,DM-3411

    BrexpiprazoleS-oxide(DM-3411)是Brexpiprazole的主要代谢产物，并通过细胞色素P4503A4(CYP3A4)代谢。Brexpiprazole是一种非典型抗精神病药，是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12nM和0.3nM。Brexpiprazole也是5-HT2A受体的拮抗剂，Ki为0.47nM。
  40. GC60641 Betahistine mesylate

    甲磺酸倍他司汀

     Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.
  41. GC60630 Befiradol hydrochloride

    NLX-112 hydrochloride; F 13640 hydrochloride

     Befiradolhydrochloride(NLX-112hydrochloride)是选择性的5-羟色胺1A(5-HT)1A受体激动剂。
  42. GC60596 Arecaidine

    槟榔次碱

     Arecaidine，一种吡啶生物碱，是一种有效的GABA吸收抑制剂。Arecaidine是H+偶联的氨基酸转运蛋白1(PAT1，SLC36A1)的底物，竞争性抑制L-脯氨酸的摄取。
  43. GC60592 APS6-45 APS6-45(Compound 10) is an orally active tumor-calibrated inhibitor (TCI) that inhibits RAS/MAPK signaling and exhibits antitumor activity.
  44. GC60563 Acrivastine D7

    阿伐斯汀-D7,BW825C D7

     AcrivastineD7(BW825CD7)是Acrivastine的一种氘代化合物。Acrivastine是一种短效的histamine1受体拮抗剂。
  45. GC60549 ABT-418 hydrochloride

    3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]异恶唑盐酸盐

     ABT-418hydrochloride是一种高效、选择性的nAChRs激动剂，具有增强认知和抗焦虑的作用。ABT-418hydrochloride激活胆碱能通道，可用于阿尔茨海默病的研究。
  46. GC60527 5,7-Dimethoxyluteolin

    5,7-二甲氧基木犀草素

     5,7-Dimethoxyluteolin，一种5,7-二甲基木犀草素衍生物，是一种多巴胺转运蛋白(DAT)活化剂，EC50值为3.417μM。
  47. GC60523 4-Methylamino antipyrine hydrochloride

    安乃近杂质C

     An active metabolite of metamizole
  48. GC60519 4-Hydroxyderricin

    4-羟基德里辛

     4-Hydroxyderricin(4-HD), the major active ingredients of Angelica keiskei Koidzumi, is a potent selective monoamine oxidase (MAO) inhibitor with mild inhibitory effect on dopamine β-hydroxylase.
  49. GC60517 4-Hydroxyatomoxetine

    4'-羟基托莫西汀

     A metabolite of atomoxetine
  50. GC60506 3-O-Methyldopa D3

    3-甲氧基-L-酪氨酸-D3,3-Methoxy-L-tyrosine-d3; 3-O-Methyl-L-DOPA-d3

     3-O-MethyldopaD3(3-Methoxy-L-tyrosineD3)是3-O-Methyldopa的氘代物。3-O-Methyldopa是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。
  51. GC60505 3-O-Methyldopa

    (S)-2-氨基-3-(4-羟基-3-甲氧苯基)丙酸,3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA

     3-O-Methyldopa(3-Methoxy-L-tyrosine)是一种由邻苯二酚-O-甲基转移酶(COMT)形成的L-DOPA代谢物。3-O-Methyldopa竞争性抑制L-DOPA和多巴胺(dopamine)的药效学。

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