Profenofos
(Synonyms: 丙溴磷) 目录号 : GC61206
Profenofos是一种乙酰胆碱酯酶抑制有机磷农药，广泛应用于农田作物、蔬菜和水果作物。
Cas No.:41198-08-7
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Profenofos is an acetylcholinesterase-inhibiting organophosphorus pesticide on field crops, vegetables, and fruit crops [1].
[1]. Madhulika Kushwaha, et al. Kushwaha, M., et al.. Profenofos, an Acetylcholinesterase-Inhibiting Organophosphorus Pesticide: A Short Review of Its Usage, Toxicity, and Biodegradation. J Environ Qual.2016 Sep;45(5):1478-1489.
| Cas No. | 41198-08-7 | SDF | |
| 别名 | 丙溴磷 | ||
| Canonical SMILES | O=P(OCC)(SCCC)OC1=CC=C(Br)C=C1Cl | ||
| 分子式 | C11H15BrClO3PS | 分子量 | 373.63 |
| 溶解度 | DMSO: 50 mg/mL (133.82 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6764 mL | 13.3822 mL | 26.7644 mL |
| 5 mM | 0.5353 mL | 2.6764 mL | 5.3529 mL |
| 10 mM | 0.2676 mL | 1.3382 mL | 2.6764 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Cyanidin-3-O-glucoside mediated photodegradation of Profenofos in water
Chemosphere 2022 Dec;308(Pt 1):136170.PMID:36037950DOI:10.1016/j.chemosphere.2022.136170.
Flavonoids can sensitize and quench the photolysis of pesticides such as Profenofos in surface water. Profenofos has been frequently detected in surface and underground water. The present study investigated the photolysis of Profenofos under various conditions, including natural and artificial light illumination, with and without cyanidin-3-O-glucoside (Cy3G) and in pure and surface water. The degradation half-lives of Profenofos in distilled water with 10 equivalents Cy3G of Profenofos were 21.7 min, 9.5 h, 12.5 h and 180 h under high-pressure mercury light, UV, Xenon lamp and solar irradiation, respectively, while those without Cy3G were 8.1 min, 6.1 h, 8.2 h and 89.9 h, respectively. The photolysis rate of Profenofos under sunlight and artificial light was reduced by 1.5-2.7 times due to Cy3G, compared to the Cy3G-free control. Under sunlight irradiation, the effects of Cy3G on Profenofos photolysis were larger than those under high-pressure mercury lamp irradiation. Cy3G also significantly reduced the photolysis rate of Profenofos under different pH conditions and in natural water. In addition, Cy3G exhibited a significant capacity of scavenging hydroxyl radicals and quenching 1O2 in water. The effect of Cy3G on Profenofos photolysis was demonstrated through their interrelations in the natural environment. These findings can help understanding of the effect of flavonoids on Profenofos photolysis and are of significance for predicting the degradation kinetics of Profenofos and accurately assessing its potential biological impacts.
Profenofos, an Acetylcholinesterase-Inhibiting Organophosphorus Pesticide: A Short Review of Its Usage, Toxicity, and Biodegradation
J Environ Qual 2016 Sep;45(5):1478-1489.PMID:27695768DOI:10.2134/jeq2016.03.0100.
Pesticides play an important role in the protection of different crops. Among the diverse sets of pesticides used all over the world, the organophosphates are the most widely used group. Profenofos [O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate] is one of the most largely used organophosphate insecticides on field crops, vegetables, and fruit crops. The World Health Organization classifies this compound as moderately hazardous (Toxicity Class II), and its residues have been found in vegetables like okra [ (L.) Moench], gooseberries ( sp.), green chilies [ (L.)], curry leaves [ (L.) Spreng], mint leaves [ (L.)], and coriander leaves [ (L.)]. Dietary intake of Profenofos (PFF) is the major exposure pathway for humans. When applied to agricultural fields, PFF residues spread into every part of the environment: ambient air, surface water, and soil. In this review, we discuss the worldwide usage of PFF pesticide, its toxic effects on humans and other living organisms in the environment, and biodegradation of this chemical by various microbial strains. To date, no complete biodegradation pathway has been established for PFF pesticide, calling for a study of this nature.
Efficacy of rhizobacteria for degradation of Profenofos and improvement in tomato growth
Int J Phytoremediation 2022;24(5):463-473.PMID:34304658DOI:10.1080/15226514.2021.1952927.
Pesticides are widely used for managing pathogens and pests for sustainable agricultural output to feed around seven billion people worldwide. After their targeted role, residues of these compounds may build up and persist in soils and in the food chain. This study evaluated the efficiency of bacterial strains capable of plant growth promotion and biodegradation of Profenofos. To execute this, bacteria were isolated from an agricultural area with a history of repeated application of Profenofos. The Profenofos degrading bacterial strains with growth-promoting characteristics were identified based on biochemical and molecular approaches through partial 16S ribosomal rRNA gene sequencing. The results revealed that one strain, Enterobacter cloacae MUG75, degraded over 90% Profenofos after 9days of incubation. Similarly, plant growth was significantly increased in plants grown in Profenofos (100mg L-1) contaminated soil inoculated with the same strain. The study demonstrated that inoculation of Profenofos degrading bacterial strains increased plant growth and Profenofos degradation. Novelty statementPesticides are extensively applied in the agriculture sector to overcome pest attacks and to increase food production to fulfill the needs of the growing world population. Residues of these pesticides can persist in the environment for long periods, may enter the groundwater reservoirs and cause harmful effects on living systems highlighting the need for bioremediation of pesticide-contaminated environments. Microbes can use pesticides as a source of carbon and energy and convert them into less toxic and non-toxic products. Application of Profenofos degrading rhizobacteria in interaction with the plants in the rhizosphere can remediate the pesticide-contaminated soils and minimize their uptake into the food chain. Hence, this approach can improve soil health and food quality without compromising the environment.
Aptamer-based microcantilever-array biosensor for Profenofos detection
Anal Chim Acta 2018 Aug 22;1020:116-122.PMID:29655422DOI:10.1016/j.aca.2018.02.072.
Profenofos, a highly poisonous organophosphorus pesticide, has been widely used in agricultural production. These pesticide residues have seriously influenced food security and threatened human health, and new methods with high sensitivity are greatly needed to detect Profenofos. Here, we developed an aptamer-based microcantilever-array sensor operated in stress mode to detect Profenofos, with advantages of being a label-free, highly sensitive, one-step immobilization method capable of quantitative and real-time detection. The microcantilevers were functionalized with a profenofos-specific aptamer (SS2-55), and then the specific binding of Profenofos to aptamer induced a deflection of the microcantilever, which was monitored using an optical method in a real-time manner. The microcantilever deflection showed a positive relationship with Profenofos concentration, and the detection limit was low to 1.3 ng mL-1 (3.5 nM) for Profenofos, which was much lower than other aptamer-based detection methods. The selectivity of the sensor was verified with another organophosphorus pesticide. Additionally, we successfully detected Profenofos dissolved in vegetable-soak solution. Our results showed that this aptamer-based microcantilever-array sensor is a convenient and label-free method for detecting Profenofos in small amounts and has great potential for food-security applications.
Studying the effects of Profenofos, an endocrine disruptor, on organogenesis of zebrafish
Environ Sci Pollut Res Int 2021 Apr;28(16):20659-20667.PMID:33405136DOI:10.1007/s11356-020-11944-0.
Profenofos is an endocrine-disrupting chemical that can enter into the aquatic ecosystem either through surface runoff or through percolation of a toxicant from the soil. In order to clarify the effect of Profenofos on the developmental stages of zebrafish, the embryos were treated with serial dilutions of Profenofos (0%, 10%, 25%, and 50% of LC50). Embryos were treated with Profenofos for 7 days or until hatching. The toxic endpoints assessed include hatching time, survival, malformation, and heartbeats of the embryos. In a 96-h test on zebrafish embryos, the LC50 of Profenofos was 0.057 mg/L. Profenofos considerably lowered survival, increased abnormalities at different ontogenetic stages, and developed malformations of different organs in a concentration-dependent fashion. The identified developmental malformations were fluid accumulation, impaired jaw, short tail, ruptured pectoral and caudal fin, curved body, thin yolk sac tube, and deformed heart. The way of looping arrangement of the heart at the early stage of embryos was significantly influenced by the higher concentration of Profenofos. Heartbeat is also reduced significantly in a concentration-dependent fashion. The results show that the zebrafish are susceptible to Profenofos even at lower concentrations in the initial stage. Therefore, when used in agricultural areas adjacent to the aquatic environment, endocrine-disrupting chemicals should be used in an appropriate manner.