Iprindole
(Synonyms: 伊普吲哚) 目录号 : GC60938
Iprindole具有抗抑郁的生物活性，是一种弱的去甲肾上腺素和5-HT摄取的抑制剂。
Cas No.:5560-72-5
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].
Iprindole produces less than 50% inhibition of the uptake of noradrenaline as well as that of 5-HT at 100 mg/kg i .p..
[1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.
| Cas No. | 5560-72-5 | SDF | |
| 别名 | 伊普吲哚 | ||
| Canonical SMILES | CN(C)CCCN1C2=C(CCCCCC2)C3=C1C=CC=C3 | ||
| 分子式 | C19H28N2 | 分子量 | 284.44 |
| 溶解度 | DMSO: 120 mg/mL (421.88 mM); Water: < 0.1 mg/mL (insoluble) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.5157 mL | 17.5784 mL | 35.1568 mL |
| 5 mM | 0.7031 mL | 3.5157 mL | 7.0314 mL |
| 10 mM | 0.3516 mL | 1.7578 mL | 3.5157 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Metabolism of some "second"- and "fourth"-generation antidepressants: Iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine
Cell Mol Neurobiol 1999 Aug;19(4):427-42.PMID:10379419DOI:10.1023/a:1006953923305.
1. This review summarizes the major known aspects of the metabolism of second-generation (Iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
Jaundice due to Iprindole
Gut 1971 Sep;12(9):705-8.PMID:4106521DOI:10.1136/gut.12.9.705.
Twenty-one patients treated for depression with Iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.
The effects of Iprindole on noradrenergic transmission in the rat anococcygeus muscle
Naunyn Schmiedebergs Arch Pharmacol 1983 Aug;323(4):321-7.PMID:6314151DOI:10.1007/BF00512470.
The effects of Iprindole on the contractile responses to field stimulation and to exogenously applied agents have been studied in the rat anococcygeus muscle. In addition the effects on the spontaneous overflow of 3H and that induced by field stimulation (following preloading of the tissue with [3H]-noradrenaline) are reported. Iprindole (10(-7)-5 X 10(-6) M) had no effect on the contractile responses to acetylcholine. Iprindole at 10(-7) or 10(-6) M was equieffective in potentiating the contractile responses to either field stimulation or to noradrenaline. With a higher concentration of Iprindole (5 X 10(-6) M) the potentiation was greater. The responses to oxymetazoline were potentiated and inhibited by Iprindole at 10(-8) and 10(-7) M, respectively. Iprindole at 10(-6) M potentiated the responses to tyramine. The effects of Iprindole at 10(-7) and 5 X 10(-6) M on the responses to field stimulation and to noradrenaline were not altered by the presence of ouabain (5 X 10(-5) M), neostigmine (10(-6) M) or yohimbine (10(-7) M). In the presence of desipramine (10(-6) M), Iprindole at 10(-7) M potentiated the contractile responses to field stimulation and to noradrenaline. The higher concentrations of Iprindole (10(-6) and 5 X 10(-6) M) inhibited the contractile responses to field stimulation and to noradrenaline in the presence of desipramine. Iprindole (10(-7) M) had no effect on the relaxant responses to field stimulation. Iprindole at 10(-7) or 10(-6) M had no effect on the spontaneous overflow of 3H or that induced by field stimulation at 2 Hz.(ABSTRACT TRUNCATED AT 250 WORDS)
Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency
Am J Pathol 1987 Oct;129(1):34-43.PMID:2821815doi
Type II alveolar epithelial cells in long-term culture typically lose the ability to synthesize surfactant together with a loss of the characteristic lamellar bodies in the cytoplasm of the cells. Iprindole, a cationic amphiphilic drug, induces lamellar body formation in cultured L-2 cells, a cell line derived from rat Type II cells, but devoid of lamellar bodies. With concentrations of 10(-7)-10(-5) M Iprindole, which approximate therapeutic plasma concentrations in human subjects, the drug induced the formation of lamellar bodies within 8 hours of incubation. This effect on cell morphology was rapidly lost after withdrawal of the drug. At concentrations of Iprindole which induced lamellar body formation, there was a significant increase in phospholipid content of the L-2 cells as well as an increase in disaturated phosphatidylcholine, an important constituent of surfactant. These studies suggest that the use of drugs such as Iprindole may represent a novel approach in the augmentation of phospholipid (and possibly surfactant) content of Type II cells in the lung.
Effect of D-amphetamine on the extracellular concentrations of glutamate and dopamine in iprindole-treated rats
Brain Res 1993 Nov 5;627(1):1-8.PMID:7904885DOI:10.1016/0006-8993(93)90741-5.
A single administration of D-amphetamine and Iprindole has been reported to produce selective, long-lasting decreases in brain dopamine (DA) content because of axon terminal degeneration. It has been found that the noncompetitive glutamate (GLU) antagonist, MK 801, blocks D-amphetamine-induced DA depletion in iprindole-treated rats. In the present study, the effect of D-amphetamine (9.2 mg/kg) and Iprindole (10 mg/kg) on the extracellular concentrations of DA and GLU was determined in the striatum of awake, freely moving rats by the use of in vivo microdialysis. D-Amphetamine significantly increased DA and GLU efflux in the striatum of iprindole-treated rats as compared to the vehicle-treated group. The increase in the extracellular concentration of GLU occurred 4-6 hr following drug administration. The concentration of DA was decreased significantly in the striatum of D-amphetamine and iprindole-treated rats 7 days following administration as compared to the vehicle-treated group. Inhibition of tyrosine hydroxylase after alpha-methylparatyrosine (150 mg/kg) administration attenuated D-amphetamine-induced DA and GLU release. The DA antagonist, haloperidol (1 mg/kg), blocked D-amphetamine-induced GLU release without affecting the increase in the extracellular concentration of DA produced by the combination of D-amphetamine and Iprindole. Both alpha-methylparatyrosine and haloperidol blocked the depletion of DA in the striatum 7 days after D-amphetamine and Iprindole as compared to the vehicle group. In addition, administration of MK-801 (2 mg/kg) 2 hr after D-amphetamine significantly attenuated the long-term (7 day) decrease in striatal DA content produced by the combination of D-amphetamine and Iprindole.2+