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Home >> Signaling Pathways >> Neuroscience

Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC49909 Met-Enkephalinamide (trifluoroacetate salt) A peptide opioid receptor agonist
  3. GC49905 Tianeptine-d6 (hydrochloride) An internal standard for the quantification of tianeptine
  4. GC49904 rac-Eletriptan-d3 (hydrobromide) An internal standard for the quantification of eletriptan
  5. GC49897 ELOVL1-22 An inhibitor of ELOVL1
  6. GC49882 Hemokinin 1 (human) (trifluoroacetate salt) A peptide agonist of NK1 receptors
  7. GC49881 Setmelanotide (trifluoroacetate salt) A peptide agonist of MC4R
  8. GC49880 Bradykinin (trifluoroacetate salt) An endogenous vasodilator
  9. GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine
  10. GC49873 Protectin D1 methyl ester An esterified form of protectin D1
  11. GC49870 Desmethyl Sibutramine (hydrochloride) An active metabolite of sibutramine
  12. GC49869 3-Methoxytyrosine An active metabolite of L-DOPA
  13. GC49865 γ-D-Glutamylglycine (trifluoroacetate salt) An excitatory amino acid antagonist
  14. GC49861 1-Carboxycyclohexaneacetic Acid A potential impurity in commercial preparations of gabapentin
  15. GC49858 Desipramine-d4 (hydrochloride) An internal standard for the quantification of desipramine
  16. GC49856 Choline-d9 (chloride) An internal standard for the quantification of choline
  17. GC49855 Harmalol (hydrochloride hydrate) A β-carboline alkaloid and an active metabolite of harmaline
  18. GC49851 Norquetiapine An active metabolite of quetiapine
  19. GC49845 Piribedil N-oxide A metabolite of piribedil
  20. GC49840 2-Methylbutyrylglycine A metabolite of isoleucine
  21. GC49838 α-Cortolone A metabolite of cortisol
  22. GC49836 Benoxaprofen An NSAID
  23. GC49829 DL-threo-β-Hydroxyaspartic Acid An EAAT inhibitor
  24. GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
  25. GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
  26. GC49818 1-Octen-3-ol A volatile organic compound
  27. GC49817 Desethoxy Quetiapine (hydrochloride) An active metabolite of quetiapine
  28. GC49815 Oleuropein aglycone A polyphenol with diverse biological activities
  29. GC49808 12-methyl Tridecanoic Acid A methylated fatty acid
  30. GC49805 Carfenazine A phenothiazine derivative
  31. GC49797 Darifenacin N-oxide A potential impurity found in commercial preparations of darifenacin
  32. GC49794 N-desmethyl Trimipramine An active metabolite of trimipramine
  33. GC49782 L-Phenylalanine-13C6 An internal standard for the quantification of phenylalanine
  34. GC49769 β-Glucogallin A plant metabolite and an aldose reductase 2 inhibitor
  35. GC49767 CYM 2503 A GAL2 receptor positive allosteric modulator
  36. GC49764 N-desmethyl Asenapine A metabolite of asenapine
  37. GC49762 Etiocholanedione A neurosteroid
  38. GC49761 Capsaicin-d3 An internal standard for the quantification of capsaicin
  39. GC49756 Safinamide Acid A potential impurity found in commercial preparations of safinamide
  40. GC49752 4,5-Desisopropylidene Topiramate An inactive metabolite of topiramate
  41. GC49747 Flunixin-d3 An internal standard for the quantification of flunixin
  42. GC64381 Nomifensine maleate An inhibitor of norepinephrine and dopamine reuptake
  43. GC64352 L-Glutamic acid-15N L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
  44. GC64332 Aceclidine A muscarinic receptor agonist
  45. GC64290 L-Phenylalanine-d8 L-Phenylalanine-d8 ((S)-2-Amino-3-phenylpropionic acid-d8) 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylalanine 是 NMDARs (KB 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。
  46. GC64285 Rivastigmine carbamate impurity Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) 是 Rivastigmine 的杂质。Rivastigmine 是一种具有口服活性的，有效的胆碱酯酶 (ChE) 抑制剂，可抑制丁酰胆碱酯酶 (BChE) 和乙酰胆碱酯酶 (AChE)，IC50 分别为 0.037 μM 和 4.15 μM。
  47. GC64265 Alosetron-13C,d3 Alosetron-13C,d3 (GR 68755-13C,d3) 是一种 13C- 和氘代标记的 Alosetron。Alosetron (GR 68755) 是一种高效、高选择性的 5-HT3 受体 (5-HT3 receptor) 拮抗剂。Alosetron 用于肠易激综合征 (IBS) 的研究。Alosetron 阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50 在 ~55 nM。Alosetron 减轻清醒或麻醉犬直肠扩张的内脏伤害性效应。具有抗炎活性。
  48. GC64249 Glycine-15N Glycine-15N 是一种 15N 标记的 Glycine。Glycine 是中枢神经系统的一种抑制性神经递质，同时也是 glutamate 的一种联合激动剂，有促进谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受体兴奋的潜能。
  49. GC64245 Glycine-13C2 Glycine-13C2 是带有 13C 标记的 Glycine。Glycine 是中枢神经系统的一种抑制性神经递质，同时也是 glutamate 的一种联合激动剂，有促进谷氨酸能 NMDA (N-methyl-D-aspartic acid ) 受体兴奋的潜能。
  50. GC64244 CX 717 CX 717 是AMPA 受体的正变构调节剂。具有抗抑郁样作用。可用于成人注意力缺陷多动障碍（ADHD）的研究。
  51. GC64243 Xanomeline tartrate Xanomeline (LY 246708) 是具有抗精神病样活性的毒蕈碱 M1/M4 受体的有效激动剂。Xanomeline (LY 246708) 增加神经元兴奋性。Xanomeline (LY 246708) 可用于研究精神分裂症。

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