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Cell Cycle/Checkpoint

Cell Cycle

Cells undergo a complex cycle of growth and division that is referred to as the cell cycle. The cell cycle consists of four phases, G1 (GAP 1), S (synthesis), G2 (GAP 2) and M (mitosis). DNA replication occurs during S phase. When cells stop dividing temporarily or indefinitely, they enter a quiescent state called G0. read more

Products for  Cell Cycle/Checkpoint

  1. Cat.No. Product Name Information
  2. GC33149 BTB-1 BTB-1是有效,选择性和可逆的有丝分裂运动蛋白Kif18A的抑制剂,IC50值为1.69μM。
  3. GC11765 Cabazitaxel Microtubule associated inhibitor
  4. GC16692 Casin GTPase Cdc42 inhibitor
  5. GC33300 CCB02 CCB02是一种选择性的CPAP-tubulin相互作用抑制剂,能够与tubulin结合,竞争β-tubulin的CPAP结合位点,IC50值为689nM,具有高效抗肿瘤活性。CCB02对其他的蛋白没有抑制作用,包括与细胞周期、中心体相关蛋白,同时对AuroraA,Plk1,Plk2,CDK2和CHK1的磷酸化状态无作用。
  6. GC14986 CCG-100602 Rho pathway inhibitor
  7. GC12795 CCG-1423 RhoA inhibitor
  8. GC38898 CCG-222740 CCG-222740 是一种有效的,选择性 Rho/MRTF 途径抑制剂。CCG-222740 也是有效的 α-平滑肌肌动蛋白蛋白表达抑制剂。CCG-222740 有效减少皮肤纤维化并阻止黑色素瘤转移。
  9. GC33006 CCT020312 CCT020312能提供有效的、具有真核起始因子2激酶3(EIF2AK3)选择性的增值控制,同时也是RNA样内质网激酶(PERK)的激动剂。
  10. GC11310 CCT129202

    Aurora kinase inhibitor,ATP-competitive and potent

  11. GC14566 CCT137690 Aurora A/B/C inhibitor
  12. GC18053 CCT241533 Potent Chk2 inhibitor
  13. GC17105 CCT241533 hydrochloride CHK2 kinase inhibitor, novel
  14. GC19092 CCT241736 CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7.5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6.2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM).
  15. GC14772 CCT244747 Potent and selective CHK1 inhibitor
  16. GC33213 CCT251455 CCT251455是有效和选择性的有丝分裂激酶单极纺锤体1(MPS1)抑制剂,IC50值为3nM。
  17. GC18051 CCT251545 analogue, Compound 51

    Potent, Selective, orally bioavailable CDK 8/19 Inhibitor

  18. GC12425 CDK inhibitor II CDK inhibitor
  19. GC14294 Cdk1/2 Inhibitor III Cdk1/cyclin B and Cdk2/cyclin A inhibitor
  20. GC11785 CDK4 inhibitor CDK4/Cyclin D1 inhibitor
  21. GC11564 Cdk4/6 Inhibitor IV Cdk4/cyclin D1 and Cdk6/cyclin D1 inhibitor

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