JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Home >> Signaling Pathways >> Membrane Transporter/Ion Channel

Membrane Transporter/Ion Channel(跨膜转运)

Cat.No. 产品名称 Information
GC12714 Gabapentin
加巴喷丁
An approved antiepileptic drug
GC12970 Furosemide
呋塞米
A loop diuretic and an inhibitor of NKCC1 and NKCC2
GC15455 VX-809
鲁玛卡托; VX-809; VRT 826809
A F508del-CFTR corrector
GC12832 Omecamtiv mecarbil
4-[[2-氟-3-[N'-(6-甲基吡啶-3-基)脲基]苯基]甲基]哌嗪-1-羧酸甲酯,CK-1827452; CK1827452
A cardiac-specific myosin activator
GC15418 TAK-438
富马酸沃诺拉赞
A selective and reversible proton pump inhibitor
GC14920 VX-661
VX-661
An investigational compound that promotes the maturation of delta F508 CFTR
GC13003 AMG-517
N-[4-[[6-[4-(三氟甲基)苯基]-4-嘧啶基]氧基]-2-苯并噻唑基]乙酰胺
A TRPV1 antagonist
GC10395 Dynasore Dynasore 作为 GTPase 抑制剂，可以快速、可逆地抑制发动蛋白活性，从而阻止内吞作用。
GC14289 Fasudil (HA-1077) HCl
盐酸法舒地尔; HA-1077 Hydrochloride; AT-877 Hydrochloride
Fasudil（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K_i为0.33μM，IC₅₀为0.158μM，对ROCK2和PKA、PKC、PKG的IC₅₀分别为4.58μM、12.30μM、1.650μM。
GC10948 Varenicline Tartrate
酒石酸伐尼克兰; CP 526555-18
An agonist of α7 and α4β2 nAChRs
GC11210 Vecuronium Bromide
维库溴铵; ORG NC 45
Vecuronium Bromide是一种非去极化神经肌肉阻断剂，特异性地作用于肌肉型乙酰胆碱受体，IC₅₀为1-2nM。
GC16036 Repaglinide
瑞格列奈; AG-EE 623ZW
An ATP-dependent potassium channel blocker
GC16859 Oligomycin A
寡霉素A; MCH 32
Oligomycin A 是一种 ATP 合酶抑制剂，可抑制线粒体偶联膜上依赖 ATP 和氧化磷酸化的过程。
GC11735 Zonisamide
唑尼沙胺; AD 810; CI 912
A broad-spectrum sulfonamide antiepileptic agent
GC13882 Ranolazine 2HCl
盐酸雷诺嗪; CVT 303 dihydrochloride; RS 43285
A piperazine derivative with cardioprotective activity
GC16570 Lansoprazole
兰索拉唑; AG-1749
Proton pump inhibitor
GC10296 Ivacaftor (VX-770)
依伐卡托; VX-770
A CFTR potentiator
GC12339 Ivermectin
伊维菌素; MK-933
A mixture of ivermectin B_1a and ivermectin B_1b
GC15524 Bumetanide
布美他尼; Ro 10-6338; PF 1593
An NKCC1 inhibitor
GC13040 TRAM-34 An IKCa1/K_Ca3.1 channel blocker
GC13166 Omeprazole
奥美拉挫; H 16868
An irreversible inhibitor of the gastric proton pump
GC12312 Cilnidipine
西尼地平; FRC-8653
An L- and N-type calcium channel blocker
GC10772 Flumazenil
氟马西尼; Ro 15-1788
A GABA_A receptor antagonist and partial agonist
GC17608 Lidocaine
利多卡因; Lignocaine
An Analytical Reference Standard
GC10444 PF-03716556
PF-03716556; PF03716556
A potent and selective H⁺/K⁺-ATPase inhibitor
GC16672 Zosuquidar
(2R)-1-{4-[(1AR,6R,10BS)-1,1-二氟-1,1A,6,10B-四氢二苯并[A,E]环丙并[C]环庚烯-6-基]哌嗪-1-基}-3-(喹啉-5-基氧基)丙-2-醇,LY335979;LY 335979;LY-335979
A modulator of P-gp
GC10038 Vernakalant Hydrochloride
盐酸维那卡兰; RSD1235 hydrochloride
Vernakalant hydrochloride 是一种混合的电压和频率依赖性 Na+ 和心房首选的 K+ 通道阻滞剂。
GC16677 Valspodar
伐司扑达,PSC 833;PSC-833;PSC833
Valspodar 是一种有效的 P-糖蛋白 (P-gp) 抑制剂，广泛用于临床前和临床研究。
GC11865 UK-5099
PF-1005023;UK5099;UK 5099;PF1005023;PF 1005023
UK-5099是一种线粒体丙酮酸载体（MPC）抑制剂，抑制丙酮酸依赖性O₂消耗的IC₅₀值为50nM。
GC10415 Tezampanel
LY 293558;LY293558;LY-293558
AMPA receptor antagonist
GC10928 Tariquidar methanesulfonate, hydrate
TARIQUIDAR二甲磺酸盐六水合物,XR 9576;XR-9576;XR9576
A P-glycoprotein inhibitor
GC11517 SEA0400
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA 0400;SEA-0400
A selective inhibitor of the Na⁺/Ca²⁺ exchanger
GC18118 SDZ 220-581
(S)-ALPHA-氨基-2'-氯-5-(膦酰基甲基)-[1,1'-联苯]-3-丙酸,SDZ 220 581
SDZ 220-581 是一种具有口服活性、强效、竞争性 NMDA 受体拮抗剂，pKi 值为 7.7。
GC13016 Safinamide
沙芬酰胺; FCE 26743; EMD 1195686
Safinamide 是一种强效、选择性和可逆的单胺氧化酶 B (MAO-B) 抑制剂 (IC50=0.098 μM)，优于 MAO-A (IC50=580 μM)。
GC10615 S0859
NBC抑制剂(S0859),S 0859;S-0859
A selective sodium/bicarbonate cotransporter blocker
GC12102 RJR-2403 oxalate
(3E)-N-甲基-4-(3-吡啶基)-3-丁烯-1-胺草酸盐,(E)-Metanicotine oxalate; Rivanicline oxalate; RJR 2403 oxalate
RJR-2403 oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) 是一种神经元烟碱受体激动剂，对 α4β2 亚型 (Ki=26 nM) 具有高选择性； > 1,000 倍的选择性比 α7 受体（Ki = 3.6 μM）。
GC12599 Retigabine dihydrochloride
瑞替加滨,D 20443 dihydrochloride;D-20443 dihydrochloride;D20443 dihydrochloride
An Analytical Reference Standard
GC12528 NS309
3-肟-6,7-二氯-1H-吲哚-2,3-二酮,NS 309;NS-309
NS309是中电导Ca²⁺激活K⁺通道KCa3.1最有效的正门控调制剂，EC₅₀为75nmol/L。
GC10270 Noopept
N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯,GVS-111;GVS111;GVS 111;SGS-111;SGS 111;SGS111
An Analytical Reference Standard
GC14417 NNC 55-0396
NNC 55-0396 dihydrochloride
A selective T-type calcium channel inhibitor
GC11411 ML-7 hydrochloride
1-(5-碘萘-1-磺酰基)-1H-六氢-1,4-二氮杂卓盐酸盐,ML 7 hydrochloride
ML-7 hydrochloride是一种选择性肌球蛋白轻链激酶（IC₅₀ = 300nM）。
GC10218 Mibefradil dihydrochloride
盐酸米贝地尔; Ro 40-5967 dihydrochloride
A general calcium channel blocker
GC12268 Mibefradil
米贝地尔,Ro 40-5967
A general calcium channel blocker
GC12045 LY 303511
8-苯基-2-(1-哌嗪基)-4H-1-苯并吡喃-4-酮,LY-303511;LY303511
An inhibitor of cell proliferation
GC15440 Lesinurad
雷西那德; RDEA594
A URAT1 inhibitor
GC16981 KN-92 phosphate
KN-92磷酸盐,KN 92 phosphate;KN92 phosphate
KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。
GC15988 KN-92 hydrochloride
KN-92盐酸盐,KN 92 hydrochloride;KN92 hydrochloride
An inactive control compound for a CaMKII inhibitor
GC15684 KB-R7943 mesylate
KB-R7943甲磺酰酸盐,KB-R7943; KB-R 7943
An inhibitor of the reverse Na⁺/Ca²⁺ exchanger
GC13316 Ivacaftor hydrate
VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate
A CFTR potentiator
GC12489 Ivacaftor benzenesulfonate
VX-770 benzenesulfonate;VX 770 benzenesulfonate;VX770 benzenesulfonate;Kalydeco benzenesulfonate
A CFTR potentiator