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Home >> Signaling Pathways >> Chromatin/Epigenetics

Chromatin/Epigenetics(染色质/表观遗传学)

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. 产品名称 Information
  2. GC14366 Thioguanine

    6-硫鸟嘌呤,Thioguanine; 2-Amino-6-purinethiol

     A thiopurine analog
  3. GC13878 EPZ005687

    EPZ 005687,EPZ-005687

     A potent, selective inhibitor of EZH2
  4. GC17334 Entacapone

    恩他卡朋

     Entacapone是一种有效的、可逆的、外周作用和具有口服活性的儿茶酚-O-甲基转移酶（COMT）抑制剂，可有效抑制大鼠肝脏总COMT，IC50和Ki值分别为20.1nM和10.7nM。
  5. GC12932 EPZ5676

    (2R,3R,4S,5R)-2-(6-氨基-9H-嘌呤-9-基)-5-((((1R,3S)-3-(2-(6-(叔丁基)-1H-苯并[D]咪唑-2-基)乙基)环丁基)(异丙基)氨基)甲基)四氢呋喃-3,4-二醇,EPZ-5676

     A highly potent DOT1L inhibitor
  6. GC17965 AZD2461

    4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮

     A PARP inhibitor
  7. GC14509 UPF 1069

    5-(2-氧代-2-苯基乙氧基)-1(2H)-异喹啉酮,UPF-1069,UPF1069

     A selective PARP2 inhibitors
  8. GC12496 INO-1001

    3-氨基苯甲酰胺,3-aminobenzamide

     A PARP inhibitor
  9. GC12390 A-966492 A PARP1 and PARP2 inhibitor
  10. GC10145 PJ34 hydrochloride

    PJ 34 Hydrochloride

     An inhibitor of poly (ADP-ribose) polymerases
  11. GC16318 AG-14361 A PARP1 inhibitor
  12. GC15353 Iniparib (BSI-201)

    3-硝基-4-碘苯甲酰胺,BSI201,BSI 201

     A PARP1 inhibitor
  13. GC15955 Rucaparib (AG-014699,PF-01367338) phosphate

    瑞卡帕布磷酸盐; AG-014699 phosphate; PF-01367338 phosphate

     A PARP1 inhibitor
  14. GC17580 Olaparib (AZD2281, Ku-0059436)

    奥拉帕尼; AZD2281; KU0059436

     Olaparib (AZD2281, Ku-0059436) 是一种有效的选择性 PARP 抑制剂，特异性靶向 PARP1 和 PARP2（IC 50 分别 = 5 nM 和 1 nM）。
  15. GC15932 BMN 673

    他拉唑帕利; BMN-673; LT-673

     A PARP inhibitor
  16. GC14245 ZM 39923 HCl

    3-[异丙基(苄基)氨基]-1-(2-萘基)-1-丙酮盐酸盐

     A potent inhibitor of JAK3
  17. GC15589 WHI-P154

    2-溴-4-(6,7-二甲氧基喹唑啉-4-基氨基)苯酚

     A JAK3 inhibitor
  18. GC17020 S-Ruxolitinib (INCB018424)

    S-鲁索替尼,S-Ruxolitinib; INCB18424

     鲁索替尼 S 对映体是鲁索替尼的 S 对映体。鲁索替尼 S 对映异构体是一种 JAK 抑制剂
  19. GC13848 LY2784544

    Gandotinib

     Potent inhibitor of JAK2
  20. GC12083 CEP-33779

    N-[3-(4-甲基-1-哌嗪基)苯基]-8-[4-(甲磺酰基)苯基]-[1,2,4]三唑并[1,5-A]吡啶-2-胺,CEP 33779,CEP33779

     A potent, orally available inhibitor of JAK2
  21. GC10035 TG101209

    N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,TG-101209

     An inhibitor of JAK2, FLT3, RET, and JAK3
  22. GC13433 AZ 960

    5-氟-2-[[(1S)-1-(4-氟苯基)乙基]氨基]-6-[(5-甲基-1H-吡唑-3-基)氨基]-3-吡啶腈,AZ-960,AZ960

     A JAK2 inhibitor
  23. GC17050 CYT387

    莫洛替尼,Cyt-387,MOMELOTINIB,CYT 387,CYT 11387

     A potent inhibitor of JAK1 and JAK2
  24. GC14844 Baricitinib (LY3009104, INCB028050)

    巴瑞替尼; LY3009104; INCB028050

     A JAK1 and JAK2 inhibitor
  25. GC15980 WP1066

    (2E)-3-(6-溴-2-吡啶基)-2-氰基-N-[(1S)-1-苯基乙基]-2-丙烯酰胺

    An inhibitor of STAT3
  26. GC16828 Tofacitinib (CP-690550,Tasocitinib)

    托法替尼; Tasocitinib; CP-690550

     Tofacitinib (CP-690550,Tasocitinib)是一种Janus激酶（JAK）抑制剂，用于治疗类风湿关节炎、银屑病关节炎、强直性脊柱炎、多关节病程青少年特发性关节炎和溃疡性结肠炎。
  27. GC12504 AZD1480

    5-氯-N2-[(1S)-1-(5-氟-2-嘧啶基)乙基]-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺,AZD 1480

     AZD1480是一种JAK抑制剂（JAK1：IC50 = 1.3nM；JAK2：IC50 = 0.4nM） 。
  28. GC14324 TG101348 (SAR302503)

    N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,Tg-101348,SAR-302503

     A JAK2 inhibitor
  29. GC17586 Tofacitinib (CP-690550) Citrate

    枸橼酸托法替尼; Tasocitinib citrate; CP-690550 citrate

     A pan-JAK inhibitor
  30. GC17836 ITF2357 (Givinostat)

    N-[4-[(羟基氨基)羰基]苯基]氨基甲酸[6-[(二乙基氨基)甲基]-2-萘基]甲酯盐酸盐水合物,ITF-2357, Givinostat (hydrochloride monohydrate)

    HDAC inhibitor with anti-inflammatory and antineoplastic activities
  31. GC16008 CUDC-101

    7-[[4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基]氧基]-N-羟基庚酰胺,CUDC101, CUDC 101

     A multi-target inhibitor of HDACs, EGFR, and HER2
  32. GC18008 PCI-34051

    N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI34051, PCI 34051

     A potent, selective HDAC8 inhibitor
  33. GC15476 JNJ-26481585

    JNJ26481585

     A pan-HDAC inhibitor
  34. GC13055 Mocetinostat (MGCD0103, MG0103)

    N-(2-氨基苯基)-4-([[4-(吡啶-3-基)嘧啶-2-基]氨基]甲基)苯甲酰胺,MGCD-0103

     An orally available HDAC inhibitor
  35. GC17390 Vorinostat (SAHA, MK0683)

    伏立诺他; SAHA; Suberoylanilide hydroxamic acid

    An HDAC inhibitor
  36. GC14998 Rocilinostat (ACY-1215)

    Ricolinostat

     A selective inhibitor of HDAC6
  37. GC14191 Ruxolitinib (INCB18424)

    芦可替尼; INCB18424

    Ruxolitinib (INCB18424)作为一种抑制剂，能够抑制Janus相关激酶(JAKs)JAK1和JAK2, IC50 分别为 3.3 nM 和 2.8 nM，Ruxolitinib介导对造血和免疫功能重要的若干细胞因子和生长因子信号。
  38. GC12422 ABT-888 (Veliparib)

    维利帕尼; ABT-888

    ABT-888 (Veliparib) (ABT-888) 是一种有效的 PARP 抑制剂，抑制 PARP1 和 PARP2，Kis 分别为 5.2 和 2.9 nM。
  39. GN10442 Curculigoside

    仙茅苷

     仙茅苷是 C. 中的主要皂苷。
  40. GN10518 Chitosamine hydrochloride

    盐酸氨基葡萄糖; D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride

     An amino monosaccharide
  41. GN10669 Glucosamine sulfate

    硫酸氨基葡萄糖; D-Glucosamine sulfate

     氨基葡萄糖硫酸盐（D-氨基葡萄糖硫酸盐）是一种氨基糖，是糖基化蛋白质和脂质生化合成的重要前体，用作膳食补充剂。
  42. GN10030 Fisetin

    漆黄素

     Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。
  43. GN10629 5,7-dihydroxychromone

    5,7-二羟基色酮

     A flavone decomposition product with diverse biological activities
  44. GN10413 Agrimol B

    仙鹤草酚 B

     A polyphenol with adipogenesis inhibitory and anticancer activities
  45. GN10114 Oroxin A

    千层纸苷A

     A flavonoid glycoside
  46. GN10627 Atractylenolide I

    白术内酯 I

     A sesquiterpene with diverse biological activities
  47. GN10040 Dehydrocorydaline

    脱氢紫堇碱; 13-Methylpalmatine

     Dehydrocorydaline是从延胡索中分离得到的一种季铵生物碱。
  48. GN10584 Ginsenoside Rk1

    人参皂苷

     人参皂甙 Rk1 是通过在高温下加工人参植物（主要是 Sung Ginseng，SG）而产生的独特成分 。
  49. GN10473 Ginkgolide C

    银杏内酯C,BN-52022; Ginkgolide-C

     A PAF receptor antagonist
  50. GN10308 Chlorogenic acid

    绿原酸; 3-O-Caffeoylquinic acid; Heriguard; NSC-407296

     Chlorogenic acid是一种有效的神经保护剂，同时具有抗病毒、抗真菌、抗氧化和抗肿瘤作用。Chlorogenic acid还参与调节葡萄糖和脂质代谢，改善胰岛素敏感性。
  51. GN10452 Paeoniflorin

    芍药苷; Peoniflorin

     A monoterpene glycoside with diverse cellular actions

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