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Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for  Neuroscience

  1. Cat.No. 产品名称 Information
  2. GC11902 PNU 96415E PNU 96415E 是一种选择性 D4/5-HT2A 拮抗剂。
  3. GC13109 Fananserin

    法南色林,RP 62203

    Fananserin (RP 62203) 是一种口服有效的选择性 5-hydroxytryptamine2 (5-HT2) 受体拮抗剂,对大鼠 5-HT2A 受体的 Ki 值为 0.37 nM。
  4. GC18068 NGB 2904 A selective D3 antagonist
  5. GC14619 Milameline hydrochloride Muscarinic receptor agonist
  6. GC17238 OSU 6162 hydrochloride Dopamine stabilizer
  7. GC11853 Tenidap

    替尼达普,CP-66248

    A COX-1 selective NSAID
  8. GC18082 Zamifenacin fumarate

    扎非那星富马酸盐; UK-76654 fumarate

    A muscarinic M3 receptor antagonist
  9. GC14842 GYKI 53655 hydrochloride

    LY300168 hydrochloride

    GYKI 53655 (LY300168) hydrochloride 是一种 α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) 拮抗剂。
  10. GC11495 Lofepramine

    洛非帕明,Lopramine

    A tricyclic antidepressant
  11. GC15132 TC 1698 dihydrochloride nicotinic α7 receptor agonist
  12. GC17564 VUF 8430 dihydrobromide A histamine H4 receptor agonist
  13. GC16018 VUF 5681 dihydrobromide histamine H3 receptor silent antagonist
  14. GC15957 Proxyfan oxalate 组胺H3受体配体
  15. GC14861 LY 379268 A selective group II mGlu2/3 receptor agonist
  16. GC15566 YM 298198 hydrochloride A non-competitive antagonist of mGluR1
  17. GC13120 Desmethyl-YM 298198 mGlu1-selective antagonist
  18. GC14429 JNJ 10191584 maleate histamine H4 receptor silent antagonist
  19. GC11406 TMPH hydrochloride neuronal nicotinic ACh receptors (nAChRs) antagonist
  20. GC16180 GT 2016 A histamine H3 receptor antagonist
  21. GC10425 Ro 90-7501 An antiviral useful in Alzheimer’s research
  22. GC17492 LY 456236 hydrochloride mGlu1 receptor antagonist
  23. GC11766 Fenobam

    非诺班

    A noncompetitive antagonist and inverse agonist of mGluR5
  24. GC11287 AMN 082 dihydrochloride An allosteric mGluR7 agonist
  25. GC13118 Dihydro-β-erythroidine hydrobromide

    DHβE hydrobromide

    Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效的、具有口服活性的竞争性神经元 nAChR 拮抗剂。
  26. GC16300 ZK 200775

    ZK200775; MPQX

    ZK 200775 (ZK200775) 是一种高度选择性的 AMPA/红藻氨酸拮抗剂,对 NMDA 几乎没有活性; Ki 值分别为 3.2 nM、100 nM 和 8.5 μ;M 分别针对 quisqualate、红藻氨酸和 NMDA。
  27. GC12737 4-Methylhistamine dihydrochloride

    2-(4-甲基-1H-咪唑基-5-基)乙胺二盐酸盐

    A histamine H4 receptor agonist
  28. GC17217 JNJ 16259685 An antagonist of mGluR1a
  29. GC12428 Ro 10-5824 dihydrochloride Ro 10-5824 dihydrochloride 是一种选择性多巴胺 D4 受体部分激动剂,Ki 为 5.2 nM。
  30. GC14260 Immethridine dihydrobromide A potent histamine H3 receptor agonist
  31. GC18139 Devazepide

    地伐西匹; L-364,718; MK-329

    Devazepide (L-364,718) 是一种有效、竞争性、选择性和口服活性的胆囊收缩素 (CCK) 受体非肽拮抗剂,对大鼠胰腺、牛胆囊和豚鼠脑 CCK 受体的 IC50 分别为 81 pM、45 pM 和 245 nM .
  32. GC12952 PNU 282987 PNU 282987是一种选择性α7烟碱乙酰胆碱受体(α7nAChR)激动剂,与抗炎途径相关,也是5-HT3受体的拮抗剂,PNU 282987对α7nAChR的EC50为154nM (Ki α7nAChR=27nM,大鼠脑匀浆),对5-HT3受体的IC50为4541nM (Ki 5-HT3R=1662nM, GR-65630)。
  33. GC16992 SCH 39166 hydrobromide A dopamine D1 receptor antagonist
  34. GC13340 AQ-RA 741 M2 antagonist,selective and high affinity
  35. GC17079 ACDPP hydrochloride mGlu5 receptor antagonist
  36. GC11795 ABT 724 trihydrochloride A dopamine D4 receptor agonist
  37. GC11223 3-MATIDA mGlu1 receptor antagonist
  38. GC15343 Eliprodil

    依利罗地,SL-820715

    An NMDA receptor antagonist
  39. GC14583 R 59-022

    DKGI-I; Diacylglycerol kinase inhibitor I

    R 59-022是一种二酰甘油激酶抑制剂(IC50 = 2.8µM)。
  40. GC14826 Carmoxirole hydrochloride

    EMD 45609 hydrochloride

    Carmoxirole hydrochloride (EMD 45609 hydrochloride) 是一种选择性的、外周作用的多巴胺 D2 受体激动剂,在体内表现出抗高血压活性。
  41. GC14258 SR 27897

    SR 27897

    A nonpeptide CCK1 antagonist
  42. GC16735 (±)-McN 5652

    5-HT uptake inhibitor

  43. GC18102 Paroxetine maleate

    马来酸帕罗西汀

    5-HT uptake inhibitor
  44. GC10633 DAU 5884 hydrochloride muscarinic M3 receptor antagonist
  45. GC11503 SKF 83822 hydrobromide SKF 83822 hydrobromide 是一种有效的多巴胺 D1 受体激动剂。
  46. GC11146 SKF 83959 hydrobromide A dopamine D1 and D5 receptor partial agonist
  47. GC12085 ROS 234 dioxalate ROS 234 dioxalate 是一种有效的 H3 拮抗剂,对豚鼠回肠 H3 受体的 pKB 为 9.46,对大鼠大脑皮层 H3 受体的 pKi 为 8.90,在体外的 ED50 为 19.12 mg/kg (ip)大鼠大脑皮层。
  48. GC16780 Ro 15-4513 Ro 15-4513,咪唑并苯二氮卓衍生物,是苯二氮卓受体 (BZR) 的部分反向激动剂。
  49. GC17525 AS 19

    A 5-HT7 receptor agonist

  50. GC13883 Ritanserin

    利坦丝林,R 55667

    A potent 5-HT2A receptor antagonist
  51. GC13126 DMeOB Negative allosteric modulator of mGlu5

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