Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC12804 KN-93 Phosphate A CaMKII inhibitor
GC10603 (-)-epicatechin gallate
表儿茶素没食子酸酯; Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate
A natural polyphenol with diverse protective actions
GC13474 Garcinol
山竹子素

Garcinol是组蛋白乙酰转移酶p300和PCAF的非特异性抑制剂，IC₅₀分别为7μM和5μM。
GC17681 Gap19 Gap19 (KQIEIKKFK) 阻断 HC 但不阻断 GJC，并且特定于 Cx43。
GC10321 Decloxizine
去氯羟嗪; UCB-1402; NSC289116
Decloxizine(UCB-1402; NSC289116) 是一种组胺 1 受体拮抗剂。
GC14612 JNJ-31020028 An antagonist of NPY receptor Y₂
GC12397 Firocoxib
非罗考昔; ML 1785713
An inhibitor of COX-2
GC16562 PEAQX
NVP-AAM077
PEAQX(NVP-AAM 077) 是一种有效的、具有口服活性的 NMDA 拮抗剂，对人 NMDA 受体的 1A/2A(IC50=270 nM) 比 1A/2B(29,600 nM) 高 15 倍。
GC13445 LY2119620
3-氨基-5-氯-N-环丙基-4-甲基-6-[2-(4-甲基-1-哌嗪基)-2-氧代乙氧基]-噻吩并[2,3-B]吡啶-2-甲酰胺
A positive allosteric modulator of M₂ and M₄ mAChRs
GC17627 Nitenpyram
烯啶虫胺
An insecticide
GC10814 Promethazine HCl
盐酸异丙嗪
A histamine H₁ receptor antagonist
GC10300 Diphenidol HCl
盐酸地芬尼多; Difenidol hydrochloride
A muscarinic acetylcholine receptor antagonist
GC11309 ARN2966
2-PMAP
An inhibitor of APP production and Aβ secretion
GC11844 Pimavanserin
匹莫范色林; ACP-103
A 5-HT_2A inverse agonist
GC11963 Oxiracetam
奥拉西坦,ISF2522
An Analytical Reference Standard
GC17047 Threo-methylphenidate hydrochloride
盐酸哌甲酯
盐酸苏哌甲酯(Threo-methylphenidate hydrochloride)是一种儿茶酚胺再摄取抑制剂,抑制多巴胺转运蛋白(DAT)和去甲肾上腺素转运蛋白(NET)。
GC10913 GTS 21 dihydrochloride
(3E)-3-[(2,4-二甲氧基苯基)亚甲基]-3,4,5,6-四氢-2,3'-联吡啶二盐酸盐,DMXB-A; DMBX-anabaseine
An agonist of α7-containing nAChRs
GC16315 D-AP5
(R)-(-)-2-氨基-5-膦酰戊酸,D-2-Amino-5-Phosphonovaleric acid; D-APV
D-AP5是一种选择性N-甲基-D-天门冬胺酸（NMDA）受体拮抗剂，K_d 值为1.4μM。
GC16247 DCG IV DCG IV 是 II 组 mGluRs 的有效激动剂，对 mGlu2R 和 mGlu3R 的 EC50 分别为 0.35 和 0.09 μM。
GC17950 MMPIP hydrochloride A reversible allosteric antagonist of mGluR7
GC12703 Philanthotoxin 74
PhTx 74 dihydrochloride
An AMPA receptor antagonist
GC17932 L-AP4
L(+)-2-氨基-4-膦酰基丁酸,L-APB
A selective Group III metabotropic glutamate receptor agonist
GC10988 J 147 J 147 是一种非常有效的口服活性神经保护剂，用于增强认知能力。
GC12800 PAOPA dopamine D2 receptor modulator
GC17095 ML 337 ML 337 是一种选择性和脑渗透性的 mGlu3 负变构调节剂，IC50 为 593 nM。
GC14869 ML 289
VU0463597
A negative allosteric modulator of mGlu3
GC10894 Methoxy-X04 Methoxy-X04是一种具有荧光性的刚果红和柯胺G的衍生物，不含酸性基团，分子量更小且亲脂性更强。
GC17385 KML 29
An inhibitor of MAGL
GC16776 QNZ 46 An antagonist of NR2C- and NR2D-subunit containing NMDA receptors
GC17585 VUF 10460 A histamine H₄ receptor agonist
GC12959 SIB 1553A hydrochloride A β4 subunit-selective nAChR agonist
GC14610 A 412997 dihydrochloride Selective D4 agonist
GC14508 PTAC oxalate muscarinic receptor ligand
GC12937 STF 083010
IRE1 Inhibitor I
An inhibitor of IRE1 endonuclease activity
GC12739 A 484954 An eEF-2K inhibitor
GC15333 A 844606 α7 nAChR partial agonist
GC16242 SEN 12333
WAY-317538
An agonist of α7 nAChRs
GC10045 MFZ 10-7 MFZ 10-7 是一种有效的 mGluR5 拮抗剂。
GC13052 SR 16584 Selective antagonist of α3β4 nicotinic acetylcholine receptors
GC12460 ADX 10059 hydrochloride Negative allosteric modulator at mGlu5
GC13715 MK 0343
MRK-409
MK0343 (MRK-409) 是一种口服生物可利用的 GABAA 受体亚型选择性部分激动剂。
GC17821 VU 0365114 A positive allosteric modulator of muscarinic M₅ receptors
GC11986 VU 0360223
CAY10651
A negative allosteric modulator of the mGlu5 receptor
GC10238 MNI 137 MNI 137 是一种有效的、选择性的负变构调节剂，适用于 II 组 mGluR。
GC16643 VU 0285683 negative allosteric modulator of mGlu5 receptors
GC13290 CMPDA A positive allosteric modulator of GluA2
GC11750 TC-N 22A TC-N 22A 是一种有效的、选择性的、具有口服活性和脑渗透性的 mGlu4 PAM，在表达人 mGlu4 的 BHK 细胞中的 EC50 为 9 nM。
GC12485 Ro 67-7476 A positive allosteric modulator of mGluR1
GC10323 VU 0360172 hydrochloride A positive allosteric modulator of mGluR5
GC14743 WY 45233 succinate
去甲文拉法辛(O-去甲文拉法辛)琥珀酸,O-Desmethylvenlafaxine succinate; Wy-45233 succinate
serotonin and noradrenalin reuptake inhibitor